{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:57:18Z","timestamp":1791496638201,"version":"4.3.4"},"reference-count":20,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,10,6]]},"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To study the organisms causing early and late onset neonatal sepsis, with special reference to multi-drug resistant gram negative bacilli, at two neonatal units (one urban, one rural) in India.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective surveillance study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 159 episodes of sepsis (81 urban and 77 rural) affecting 158 babies. Gram negative bacilli caused 117 infections (68%) and predominated at both centres in both early and late sepsis. <jats:italic>Klebsiella pneumoniae<\/jats:italic> was the commonest organism, causing 61 infections (38.3%). In early sepsis (0\u20132 days), non-fermenting gram negative bacilli caused 42.1% of infections at the urban centre; there were no cases of early Group B Streptococcus sepsis. Late onset sepsis was mainly caused by gram negative bacilli at both centres. Multi-drug resistance of over 80% of early-onset gram negative organisms to ampicillin, third generation cephalosporins and gentamicin indicates that these multi-resistant organisms are almost certainly circulating widely in the community. The overall mortality from early sepsis was 27.3% (9 of 33) and from late sepsis was 26.2% (33 of 126). Gram negative bacilli caused all deaths from early sepsis and 87.5% of deaths from late sepsis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study shows that multi-drug resistant gram negative bacilli are a major cause of early and late neonatal sepsis in India and are almost certainly widespread in the community.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2011-300097","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T21:29:51Z","timestamp":1323379791000},"page":"F182-F187","source":"Crossref","is-referenced-by-count":67,"title":["Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India"],"prefix":"10.1136","volume":"97","author":[{"given":"Rajlakshmi","family":"Viswanathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumarendu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulagna","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparna","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syamal","family":"Sardar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"2025090503510350000_97.3.F182.1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.1.F52"},{"key":"2025090503510350000_97.3.F182.2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181958755"},{"key":"2025090503510350000_97.3.F182.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.139865"},{"key":"2025090503510350000_97.3.F182.4","unstructured":"National Neonatal Perinatal Database. Report for Year 2002\u20132003. India: National Neonatology Forum."},{"key":"2025090503510350000_97.3.F182.5","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-010-0272-1"},{"key":"2025090503510350000_97.3.F182.6","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmr027"},{"key":"2025090503510350000_97.3.F182.7","unstructured":"CLSI Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement. CLSI Document M100-S18. Wayne, PA: Clinical and Laboratory Standards Institute, 2008."},{"key":"2025090503510350000_97.3.F182.8","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki145"},{"key":"2025090503510350000_97.3.F182.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.06.005"},{"key":"2025090503510350000_97.3.F182.10","first-page":"241","article-title":"Bacterial profile of early versus late onset neonatal sepsis in a North Indian tertiary care centre: heading towards a change","volume":"4","author":"Sundaram","year":"2009","journal-title":"J Ped Inf Dis"},{"key":"2025090503510350000_97.3.F182.11","first-page":"110","article-title":"Enterobacter cloacae: a predominant pathogen in neonatal septicaemia","volume":"20","author":"Mahapatra","year":"2002","journal-title":"Indian J Med Microbiol"},{"key":"2025090503510350000_97.3.F182.12","first-page":"136","article-title":"Changing pattern of bacterial isolates and antimicrobial susceptibility in neonatal infections in Korle Bu Teaching Hospital, Ghana","volume":"84","author":"Enweronu-Laryea","year":"2007","journal-title":"East Afr Med J"},{"key":"2025090503510350000_97.3.F182.13","doi-asserted-by":"publisher","DOI":"10.1080\/08035259950168577"},{"key":"2025090503510350000_97.3.F182.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.03.003"},{"key":"2025090503510350000_97.3.F182.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00189-8"},{"key":"2025090503510350000_97.3.F182.16","first-page":"93","article-title":"Millennium bugs","volume":"47","author":"Pennington","year":"2000","journal-title":"Biologist (London)"},{"key":"2025090503510350000_97.3.F182.17","first-page":"119","article-title":"Multidrug resistant Klebsiella pneumoniae in NICU\u2013what next? Trend of antibiotic resistance","volume":"5","author":"Tagare","year":"2010","journal-title":"J Ped Inf Dis"},{"key":"2025090503510350000_97.3.F182.18","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.178483"},{"key":"2025090503510350000_97.3.F182.19","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.538856"},{"key":"2025090503510350000_97.3.F182.20","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr068"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2011-300097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:51:13Z","timestamp":1757069473000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2011-300097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,7]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,4,17]]},"published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1136\/archdischild-2011-300097"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2011-300097","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,7]]}}}