{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:18:02Z","timestamp":1760217482613,"version":"3.44.0"},"reference-count":40,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,7,25]]},"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the characteristics of dopamine D2 receptor gene (DRD2) polymorphisms in drug-exposed and unexposed neonates and the relationship to neonatal abstinence syndrome (NAS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective case-control analysis between drug-exposed and unexposed infants between DRD2 polymorphisms, drug exposure and NAS treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Drug-exposed (n=48) and drug-free (n=49) infants born between March 1999 and December 2006.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Analysis of DNA for the Taq1A, -141Ins\/Del and Ser311Cys DRD2 polymorphisms. Drug exposure was determined by antenatal maternal drug and alcohol history. Frequency measures of DRD2 polymorphisms were compared between drug-exposed infants, treatment NAS medication and with control infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Tertiary maternity hospital, Sydney, Australia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>All infants were born in a good condition (25.7% &lt;37 weeks gestation). Opiates (methadone and heroin) were used by 45 (93.8%) of drug-exposed mothers. The A2A2 allele was more common in drug-exposed infants (37 (77.0%) versus 23 (46.9%), p=0.003) but the A1A2 allele was more common in control infants (23 (46.9%) versus 4 (8.3%), p=0.00002). The-ins allele was more common in control (39 (79.6%) versus 20 (41.7%), p=&lt;0.01) and unmedicated drug-exposed (14\/25 (56%) versus 5\/23 (21.7%), p=0.02) infants. The majority of infants (41 (83.7%) controls versus 41 (85.4%), p=1.000) expressed the least common, Ser polymorphism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DRD2 polymorphisms are detectable from DNA obtained from stored blood spots. The \u2013ins allele is more common in control and unmedicated drug-exposed infants. Further study is recommended to explore postneonatal outcomes especially in relation to neuropsychiatric behaviours.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2011-300235","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T22:05:19Z","timestamp":1317074719000},"page":"F193-F198","source":"Crossref","is-referenced-by-count":15,"title":["Dopamine D2 receptor gene polymorphisms in newborn infants of drug-using women"],"prefix":"10.1136","volume":"97","author":[{"given":"Ju Lee","family":"Oei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Xiu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E","family":"Abdel-Latif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Vunnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Al-Amry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Clews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Falconer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Feller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"2025090509430541000_97.3.F193.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.08.037"},{"key":"2025090509430541000_97.3.F193.2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10078"},{"key":"2025090509430541000_97.3.F193.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.032"},{"key":"2025090509430541000_97.3.F193.4","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.11.2236"},{"key":"2025090509430541000_97.3.F193.5","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-200010030-00005"},{"key":"2025090509430541000_97.3.F193.6","doi-asserted-by":"crossref","unstructured":"Bressan RA Crippa JA . The role of dopamine in reward and pleasure behaviour\u2013review of data from preclinical research. Acta Psychiatr Scand Suppl 2005:14\u201321.","DOI":"10.1111\/j.1600-0447.2005.00540.x"},{"key":"2025090509430541000_97.3.F193.7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.b.30080","article-title":"Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome","volume":"132B","author":"Bowirrat","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"2025090509430541000_97.3.F193.8","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agp041"},{"key":"2025090509430541000_97.3.F193.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.02.019"},{"key":"2025090509430541000_97.3.F193.10","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2009000200004"},{"key":"2025090509430541000_97.3.F193.11","first-page":"131","article-title":"The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years","volume":"31","author":"Paclt","year":"2010","journal-title":"Neuro Endocrinol Lett"},{"key":"2025090509430541000_97.3.F193.12","doi-asserted-by":"publisher","DOI":"10.1375\/twin.9.1.38"},{"key":"2025090509430541000_97.3.F193.13","doi-asserted-by":"publisher","DOI":"10.1080\/09595230701494416"},{"key":"2025090509430541000_97.3.F193.14","doi-asserted-by":"publisher","DOI":"10.1080\/09595230801919452"},{"key":"2025090509430541000_97.3.F193.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.00994.x"},{"key":"2025090509430541000_97.3.F193.16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.036863"},{"key":"2025090509430541000_97.3.F193.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.033"},{"key":"2025090509430541000_97.3.F193.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00657.x"},{"key":"2025090509430541000_97.3.F193.19","first-page":"141","article-title":"Neonatal abstinence syndrome: assessment and management","volume":"2","author":"Finnegan","year":"1975","journal-title":"Addict Dis"},{"key":"2025090509430541000_97.3.F193.20","unstructured":"NSW Department of Health. Neonatal Abstinence Syndrome Guidelines, 2004. http:\/\/www.health.nsw.gov.au\/policies\/pd\/2005\/pdf\/PD2005_494.pdf (accessed 28 April 2009)."},{"key":"2025090509430541000_97.3.F193.21","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200101000-00005"},{"key":"2025090509430541000_97.3.F193.22","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.12.2197-a"},{"key":"2025090509430541000_97.3.F193.23","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1196"},{"key":"2025090509430541000_97.3.F193.24","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200108000-00009"},{"key":"2025090509430541000_97.3.F193.25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/diabetes.50.4.901","article-title":"A Ser311Cys mutation in the human dopamine receptor D2 gene is associated with reduced energy expenditure","volume":"50","author":"Tataranni","year":"2001","journal-title":"Diabetes"},{"key":"2025090509430541000_97.3.F193.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.03.012"},{"key":"2025090509430541000_97.3.F193.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.04.008"},{"key":"2025090509430541000_97.3.F193.28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161550"},{"key":"2025090509430541000_97.3.F193.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.02.003"},{"key":"2025090509430541000_97.3.F193.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05835.x"},{"key":"2025090509430541000_97.3.F193.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26022-6"},{"key":"2025090509430541000_97.3.F193.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.03.012"},{"key":"2025090509430541000_97.3.F193.33","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.157305"},{"key":"2025090509430541000_97.3.F193.34","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3282f01aa3"},{"key":"2025090509430541000_97.3.F193.35","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800655"},{"key":"2025090509430541000_97.3.F193.36","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810310066012"},{"key":"2025090509430541000_97.3.F193.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00492.x"},{"key":"2025090509430541000_97.3.F193.38","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10R07FM"},{"key":"2025090509430541000_97.3.F193.39","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970725)74:4<386::AID-AJMG9>3.0.CO;2-N"},{"key":"2025090509430541000_97.3.F193.40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2350-11-24","article-title":"Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study","volume":"11","author":"Prasad","year":"2010","journal-title":"BMC Med Genet"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2011-300235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T16:43:14Z","timestamp":1757090594000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2011-300235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,26]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,4,17]]},"published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1136\/archdischild-2011-300235"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2011-300235","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"type":"print","value":"1359-2998"},{"type":"electronic","value":"1468-2052"}],"subject":[],"published":{"date-parts":[[2011,9,26]]}}}