{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:20:13Z","timestamp":1792225213110,"version":"4.4.0"},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2011,11,2]]},"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the efficacy and safety of oral versus intravenous ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in less mature preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective, randomised controlled study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Tertiary neonatal intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and interventions<\/jats:title>\n                  <jats:p>The study enrolled 80 preterm infants with gestational age \u226428 weeks, birth weight &lt;1000 g, postnatal age 48 to 96 h, and had echocardiographically confirmed significant PDA. Seventy extremely low birthweight (ELBW) preterm infants received either intravenous or oral ibuprofen randomly as an initial dose of 10 mg\/kg, followed by 5 mg\/kg at 24 and 48 h.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The success rate and the safety of the drugs in ELBW preterm infants were the major outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PDA closure rate was significantly higher with oral ibuprofen (83.3% vs 61.7%) after the first course of the treatment (p=0.04). Although the primary closure rate was marginally higher in the oral ibuprofen group, the need for a second course of ibuprofen during the whole hospitalisation was similar between groups: 11 of 36 in oral versus 15 of 34 in intravenous groups (p=0.24) because of a higher reopening rate in the oral group. In addition to no increase in side effects with oral ibuprofen use, the need for postnatal steroid use for chronic lung disease was significantly lower in oral ibuprofen group (p=0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Oral ibuprofen is as effective as intravenous ibuprofen for PDA closure even in ELBW infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2011-300532","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T21:09:06Z","timestamp":1323205746000},"page":"F279-F283","source":"Crossref","is-referenced-by-count":81,"title":["Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants"],"prefix":"10.1136","volume":"97","author":[{"given":"Omer","family":"Erdeve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sad\u0131k","family":"Yurttutan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahide","family":"Altug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin","family":"Gokmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Dilmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serife Suna","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"Uras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,12,5]]},"reference":[{"key":"2025090503373679000_97.4.F279.1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.97"},{"key":"2025090503373679000_97.4.F279.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.08.011"},{"key":"2025090503373679000_97.4.F279.3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211465"},{"key":"2025090503373679000_97.4.F279.4","doi-asserted-by":"crossref","unstructured":"Ohlsson A Walia R Shah SS . Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants. 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Ibuprofen for the prevention of patent ductus arteriosus in preterm and\/or low birth weight infants. 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