{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:45:16Z","timestamp":1790703916860,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To identify infant, obstetrical and maternal characteristics associated with arterial ischaemic stroke (AIS) and venous thromboembolism (VTE) in infancy (&lt;1 year).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Nationwide, population-based nested case-control study. All infants with a verified first-time diagnosis of AIS, VTE or both in Denmark through the years 1994\u20132006 were included, and 10 population controls were selected for each case.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Case-infants presented with AIS (n=71) or VTE (n=38). AIS in infancy was associated with primiparity (adjusted OR 5.9 CI 95% 3.0 to 11.6)), delivery by an emergency caesarean section (adjusted OR 1.9 (CI 95% 1.0 to 3.3)), and post-term birth (adjusted OR 2.2 (CI 95% 1.1 to 4.8)). Male sex was associated with an increased risk of AIS among neonates (crude OR 1.8 (CI 95% 1.0 to 3.4)) but not among later born (crude OR 0.6 (CI 95% 0.2 to 1.4)). Risk factors for VTE in infancy included preterm birth (adjusted OR 5.5 (CI 95% 1.8 to 16.9)), low Apgar score (adjusted OR 9.2 (CI 95% 1.9 to 45.2)), and multiple births (adjusted OR 7.1 (CI 95% 1.1 to 48.1)). Previous maternal thromboembolism and pregnancy-related disorders were not associated with the risk of thromboembolism in the children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Several apparently independent infant, obstetrical and maternal characteristics were associated with thromboembolism in early life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2011-300665","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T20:52:55Z","timestamp":1331671975000},"page":"F417-F422","source":"Crossref","is-referenced-by-count":27,"title":["Infant, obstetrical and maternal characteristics associated with thromboembolism in infancy: a nationwide population-based case-control study"],"prefix":"10.1136","volume":"97","author":[{"given":"Ruta","family":"Tuckuviene","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark"},{"name":"Department of Paediatrics, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette Luther","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Helgested","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Holmager","family":"Hundborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Risom","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"2025090513520381000_97.6.F417.1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200006000-00013"},{"key":"2025090513520381000_97.6.F417.2","doi-asserted-by":"publisher","DOI":"10.1177\/088307380001500508"},{"key":"2025090513520381000_97.6.F417.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.02100.x"},{"key":"2025090513520381000_97.6.F417.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.116"},{"key":"2025090513520381000_97.6.F417.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0385"},{"key":"2025090513520381000_97.6.F417.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.723"},{"key":"2025090513520381000_97.6.F417.7","doi-asserted-by":"publisher","DOI":"10.1136\/fn.76.3.F163"},{"key":"2025090513520381000_97.6.F417.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000087598.05977.45"},{"key":"2025090513520381000_97.6.F417.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.052"},{"key":"2025090513520381000_97.6.F417.10","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118192"},{"key":"2025090513520381000_97.6.F417.11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"Schmidt","year":"1995","journal-title":"Pediatrics"},{"key":"2025090513520381000_97.6.F417.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.05.004"},{"key":"2025090513520381000_97.6.F417.13","doi-asserted-by":"crossref","first-page":"F88","DOI":"10.1136\/fn.76.2.F88","article-title":"Unilateral neonatal cerebral infarction in full term infants","volume":"76","author":"Estan","year":"1997","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025090513520381000_97.6.F417.14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2147\/CLEP.S10334","article-title":"Predictive value of pediatric thrombosis diagnoses in the Danish National Patient Registry","volume":"2","author":"Tuckuviene","year":"2010","journal-title":"Clin Epidemiol"},{"key":"2025090513520381000_97.6.F417.15","first-page":"263","article-title":"The Danish National Hospital Register. A valuable source of data for modern health sciences","volume":"46","author":"Andersen","year":"1999","journal-title":"Dan Med Bull"},{"key":"2025090513520381000_97.6.F417.16","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen","year":"2006","journal-title":"Dan Med Bull"},{"key":"2025090513520381000_97.6.F417.17","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen","year":"1998","journal-title":"Dan Med Bull"},{"key":"2025090513520381000_97.6.F417.18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1078"},{"key":"2025090513520381000_97.6.F417.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07877.x"},{"key":"2025090513520381000_97.6.F417.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.009"},{"key":"2025090513520381000_97.6.F417.21","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190070301"},{"key":"2025090513520381000_97.6.F417.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.003"},{"key":"2025090513520381000_97.6.F417.23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1160\/TH04-04-0207","article-title":"Systemic thromboembolism in children. Data from the 1-800-NO-CLOTS Consultation Service","volume":"92","author":"Kuhle","year":"2004","journal-title":"Thromb Haemost"},{"key":"2025090513520381000_97.6.F417.24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1160\/TH04-02-0131","article-title":"A case series of 72 neonates with renal vein thrombosis. Data from the 1-800-NO-CLOTS Registry","volume":"92","author":"Kuhle","year":"2004","journal-title":"Thromb Haemost"},{"key":"2025090513520381000_97.6.F417.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.583542"},{"key":"2025090513520381000_97.6.F417.26","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.2.435"},{"key":"2025090513520381000_97.6.F417.27","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm139"},{"key":"2025090513520381000_97.6.F417.28","doi-asserted-by":"publisher","DOI":"10.1007\/BF02260869"},{"key":"2025090513520381000_97.6.F417.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.07.004"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2011-300665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:52:13Z","timestamp":1757105533000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2011-300665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,13]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,10,18]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1136\/archdischild-2011-300665"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2011-300665","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,13]]}}}