{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:04:26Z","timestamp":1790960666516,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2012,4,21]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the applicability and potential effectiveness of a technique of minimally-invasive surfactant therapy (MIST) in preterm infants on continuous positive airway pressure (CPAP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An open feasibility study of MIST was conducted at two sites. Infants were eligible for MIST if needing CPAP pressure \u22657 cm H<jats:sub>2<\/jats:sub>O and FiO<jats:sub>2<\/jats:sub> \u22650.3 (25\u201328 weeks gestation, n=38) or \u22650.35 (29\u201332 weeks, n=23). Without premedication, a narrow-bore catheter was inserted through the vocal cords under direct vision. Surfactant (100 or 200 mg\/kg Curosurf) was then instilled, followed by reinstitution of CPAP. Outcomes were compared between surfactant-treated infants and historical controls achieving the same CPAP and FiO<jats:sub>2<\/jats:sub> thresholds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Surfactant was successfully administered via MIST in all cases, with a rapid and sustained reduction in FiO<jats:sub>2<\/jats:sub> thereafter. For infants at 25\u201328 weeks gestation, need for intubation &lt;72 h was diminished after MIST compared with controls (32% vs 68%; OR 0.21, 95% CI 0.083 to 0.55), with a similar trend at 29\u201332 weeks (22% vs 45%; OR 0.34, 95% CI 0.11 to 1.1). Duration of ventilation and incidence of bronchopulmonary dysplasia were similar, but infants receiving MIST had a shorter duration of oxygen therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Surfactant delivery via a narrow-bore tracheal catheter is feasible and potentially effective, and deserves further investigation in clinical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2011-301314","type":"journal-article","created":{"date-parts":[[2012,6,10]],"date-time":"2012-06-10T05:39:10Z","timestamp":1339306750000},"page":"F122-F126","source":"Crossref","is-referenced-by-count":177,"title":["Minimally-invasive surfactant therapy in preterm infants on continuous positive airway pressure"],"prefix":"10.1136","volume":"98","clinical-trial-number":[{"clinical-trial-number":"nct00751959","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Peter A","family":"Dargaville","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Australia"},{"name":"Menzies Research Institute, Hobart, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Aiyappan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Australia"},{"name":"Neonatal Services, Royal Women's Hospital, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio G","family":"De Paoli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Hobart, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl A","family":"Kuschel","sequence":"additional","affiliation":[{"name":"Neonatal Services, Royal Women's Hospital, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia"},{"name":"Murdoch Childrens Research Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Omar F","family":"Kamlin","sequence":"additional","affiliation":[{"name":"Neonatal Services, Royal Women's Hospital, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia"},{"name":"Murdoch Childrens Research Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B","family":"Carlin","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Melbourne, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Davis","sequence":"additional","affiliation":[{"name":"Neonatal Services, Royal Women's Hospital, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia"},{"name":"Murdoch Childrens Research Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,6,9]]},"reference":[{"key":"2025090513562531000_98.2.F122.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"2025090513562531000_98.2.F122.2","unstructured":"Donoghue D . The report of the Australian and New Zealand Neonatal Network, 2006. 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