{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:40:33Z","timestamp":1763563233228},"reference-count":0,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Dengue is a vector-borne viral infection of global importance. Several pathogenetic mechanisms such as immune enhancement and selection pressure have been proposed and febrile, critical and recovery phases have been identified. A new classification proposed by WHO has recently been introduced where definitions have been changed to \u2018probable dengue\u2019, \u2018dengue with warning signs\u2019 and \u2018severe dengue\u2019. The majority of dengue viral infections are self-limiting, but complications have high morbidity and mortality. The diagnosis of dengue viral infection is essentially clinical, although confirmation requires laboratory tests including serology, NS1 antigen detection, PCR and viral cultures. There are no specific anti-dengue drugs and treatment is basically supportive and consists of early recognition of complications and appropriate fluid therapy. A number of candidate vaccines are under development.<\/jats:p>","DOI":"10.1136\/archdischild-2012-301710","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T22:21:09Z","timestamp":1342650069000},"page":"907-912","source":"Crossref","is-referenced-by-count":13,"title":["Dengue viral infection in children: a perspective"],"prefix":"10.1136","volume":"97","author":[{"given":"S","family":"Balasubramanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bala","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumanth","family":"Amperayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,7,17]]},"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2012-301710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:13:55Z","timestamp":1601108035000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2012-301710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,17]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,9,13]]},"published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1136\/archdischild-2012-301710"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2012-301710","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,17]]}}}