{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:56:09Z","timestamp":1790146569735,"version":"4.0.1"},"reference-count":0,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of sleep-disordered breathing (SDB) symptoms and respiratory events during sleep in infants with cleft lip and\/or palate (CL\/P).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Cleft palate clinic, tertiary care paediatric hospital, before palate surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Consecutive newborn infants with CL\/P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Demographics, clinical history, sleep symptoms, facial measurement and polysomnography (PSG; sleep study) data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty infants completed PSG at 2.7\u00b12.3\u2005months; 56% were male, and 30% had a clinical diagnosis of Pierre Robin sequence (PRS) or a syndrome. The majority of infants (75%) were reported to snore frequently or constantly, while 74% were reported to have heavy or loud breathing during sleep. The frequency of parent-reported difficulty with breathing during sleep was 10% for infants with isolated CL\/P, 33% for those with syndrome, and 43% for PRS (\u03c7<jats:sup>2<\/jats:sup> 16.1, p&lt;0.05). All infants had an Obstructive\u2013Mixed Apnoea\u2013Hypopnoea Index (OMAHI) &gt;1 event\/h, and 75% had an OMAHI &gt;3 events\/h. Infants with PRS had higher OMAHI (34.3\u00b15.1) than infants with isolated CL\/P (7.6\u00b11.2) or infants with syndromes (15.6\u00b15.7, F stat, p&lt;0.001). Multivariate analysis showed that PRS was associated with higher OMAHI (B 0.53\u00b10.22, p=0.022), but the majority of the variance for SDB was unexplained (constant B 1.31\u00b10.55, p=0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results highlight that infants across the spectrum of CL\/P have a high risk of SDB symptoms and obstructive respiratory events before palate surgery. Clinicians should enquire about symptoms of SDB and consider investigation with polysomnography in all infants with CL\/P.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2012-302104","type":"journal-article","created":{"date-parts":[[2012,10,7]],"date-time":"2012-10-07T02:06:39Z","timestamp":1349575599000},"page":"1058-1063","source":"Crossref","is-referenced-by-count":93,"title":["The spectrum of sleep-disordered breathing symptoms and respiratory events in infants with cleft lip and\/or palate"],"prefix":"10.1136","volume":"97","author":[{"given":"Joanna E","family":"MacLean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fitzsimons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,10,6]]},"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2012-302104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:17:46Z","timestamp":1601108266000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2012-302104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,6]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,11,19]]},"published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1136\/archdischild-2012-302104"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2012-302104","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,6]]}}}