{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:49:13Z","timestamp":1785523753250,"version":"3.56.0"},"reference-count":23,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2013,1,4]]},"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hypertrophic cardiomyopathy (HCM) is a well-recognised complication in infants of diabetic mothers and is attributed to a compensatory increase in fetal insulin secretion. Infants with congenital hyperinsulinism have excessive prenatal and postnatal insulin secretion due to defects in pathways of insulin secretion (most commonly the K<jats:sub>ATP<\/jats:sub> channel). HCM has been reported in a few neonates with hyperinsulinism, but its extent and risk factors for its development have not been evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective chart review of infants, age &lt;3\u2005months, with congenital hyperinsulinism managed by Children's Hospital of Philadelphia over a 3.5-year period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data<\/jats:title>\n                  <jats:p>Gestational age, birth weight, hyperinsulinism form and treatments, echocardiogram results, cardiac\/respiratory complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>68 infants were included, 58 requiring pancreatectomy for diffuse (n=28) or focal (n=30) disease, 10 were diazoxide-sensitive. Twenty-five had echocardiograms performed. Ten had HCM, all of whom required pancreatectomy and eight of whom had confirmed ATP-sensitive potassium-hyperinsulinism. Subjects with HCM had younger gestational age 36(32, 38) than their surgical counterparts without HCM 38 (31.6, 43), p=0.02.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>HCM appears common in infants with severe hyperinsulinism. Routine echocardiogram and EKG of at-risk newborns should be considered. Fetal hyperinsulinism is the likely mediating factor for HCM in HI infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2012-302546","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T21:29:56Z","timestamp":1359754196000},"page":"F351-F354","source":"Crossref","is-referenced-by-count":48,"title":["Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism"],"prefix":"10.1136","volume":"98","author":[{"given":"TingTing","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Endocrinology & Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl S","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A","family":"Stanley","sequence":"additional","affiliation":[{"name":"Division of Endocrinology & Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2025090511494244000_98.4.F351.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80302-9"},{"key":"2025090511494244000_98.4.F351.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70253-9"},{"key":"2025090511494244000_98.4.F351.3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.4.258"},{"key":"2025090511494244000_98.4.F351.4","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(95)00080-1"},{"key":"2025090511494244000_98.4.F351.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl416"},{"key":"2025090511494244000_98.4.F351.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238369"},{"key":"2025090511494244000_98.4.F351.7","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199811000-00015"},{"key":"2025090511494244000_98.4.F351.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01455-7"},{"key":"2025090511494244000_98.4.F351.9","first-page":"17","article-title":"Heart disease in infants of diabetic mothers","volume":"3","author":"Narchi","year":"2000","journal-title":"Images Paediatr Cardiol"},{"key":"2025090511494244000_98.4.F351.10","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0368"},{"key":"2025090511494244000_98.4.F351.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80862-6"},{"key":"2025090511494244000_98.4.F351.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80442-1"},{"key":"2025090511494244000_98.4.F351.13","first-page":"359","article-title":"Reversible hypertrophic cardiomyopathy in congenital hyperinsulinism","volume":"54","author":"Massin","year":"1999","journal-title":"Acta Cardiol"},{"key":"2025090511494244000_98.4.F351.14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.9.822"},{"key":"2025090511494244000_98.4.F351.15","unstructured":"Park M . Pediatric cardiology for practioners. 5th edn. Philadelphia: Mosby, 2008."},{"key":"2025090511494244000_98.4.F351.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00051-5"},{"key":"2025090511494244000_98.4.F351.17","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000018952.70505.F1"},{"key":"2025090511494244000_98.4.F351.18","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0538-8"},{"key":"2025090511494244000_98.4.F351.19","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900075"},{"key":"2025090511494244000_98.4.F351.20","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050623"},{"key":"2025090511494244000_98.4.F351.21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.6.570"},{"key":"2025090511494244000_98.4.F351.22","doi-asserted-by":"publisher","DOI":"10.1038\/ng1329"},{"key":"2025090511494244000_98.4.F351.23","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/01.CIR.61.2.441","article-title":"Characterization of the cardiomyopathy in infants of diabetic mothers","volume":"61","author":"Gutgesell","year":"1980","journal-title":"Circulation"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2012-302546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:03:19Z","timestamp":1757098999000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2012-302546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,1]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,6,13]]},"published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1136\/archdischild-2012-302546"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2012-302546","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,1]]}}}