{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:49:52Z","timestamp":1778273392587,"version":"3.51.4"},"reference-count":23,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2013,2,18]]},"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To describe incidence, presentation, treatment and short term outcomes of severe neonatal hypernatraemia (SNH, sodium \u2265160\u2005mmol\/l).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective, population based surveillance study over 13\u2005months using the British Paediatric Surveillance Unit. Cases were &gt;33\u2005weeks gestation at birth, fed breast or formula milk and &lt;28\u2005days of age at presentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 62 cases of SNH reported (7, 95% CI 5.4 to 9.0 per 1\u200500\u2005000 live births), 61 mothers had intended to achieve exclusive breast feeding. Infants presented at median day 6 (range 2\u201317) with median weight loss of 19.5% (range 8.9\u201330.9). 12 had jaundice and 57 weight loss as a presenting feature. 58 presented with weight loss \u226515%. 25 babies had not stooled in the 24\u2005h prior to admission. Serum sodium fell by median 12.9\u2005mmol\/l per 24\u2005h (range 0\u201330). No baby died, had seizures or coma or was treated with dialysis or a central line. At discharge, babies had regained 11% of initial birth weight after a median admission of 5 (range 2\u201314) days. 10 were exclusively breast fed on discharge from hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Neonatal hypernatraemia at this level, in this population, is strongly associated with weight loss. It occurs almost exclusively after attempts to initiate breast feeding, occurs uncommonly and does not appear to be associated with serious short term morbidities, beyond admission to hospital.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2012-302908","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T01:02:32Z","timestamp":1363741352000},"page":"F384-F387","source":"Crossref","is-referenced-by-count":33,"title":["Severe neonatal hypernatraemia: a population based study"],"prefix":"10.1136","volume":"98","author":[{"given":"Sam Joseph","family":"Oddie","sequence":"first","affiliation":[{"name":"Bradford Neonatology, Bradford Royal Infirmary, Bradford, West Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Craven","sequence":"additional","affiliation":[{"name":"Sheffield Children's Hospital, Western Bank, Sheffield, 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