{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:37:41Z","timestamp":1793504261449,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2012,10,29]]},"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate developmental and social-emotional outcomes at 8\u2005years of age for children with congenital diaphragmatic hernia (CDH), treated with or without neonatal extracorporeal membrane oxygenation (ECMO) between January 1999 and December 2003.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cohort study with structural prospective follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Level III University Hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>35 children (ECMO: n=16; non-ECMO: n=19) were assessed at 8\u2005years of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>None.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Intelligence and motor function. Concentration, behaviour, school performance, competence and health status were also analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean (SD) intelligence for the ECMO group was 91.7 (19.5) versus 111.6 (20.9) for the non-ECMO group (p=0.015). Motor problems were apparent in 16% of all participants and differed significantly from the norm (p=0.015) without differences between treatment groups. For all participants, problems with concentration (68%, p&lt;0.001) and with behavioural attention (33%, p=0.021) occurred more frequently than in reference groups, with no difference between treatment groups. School performance and competence were not affected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Children with CDH\u2014whether or not treated with neonatal ECMO\u2014are at risk for long-term morbidity especially in the areas of motor function and concentration. Despite their impairment, children with CDH have a well-developed feeling of self-competence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2012-303020","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T21:22:17Z","timestamp":1355347337000},"page":"F316-F322","source":"Crossref","is-referenced-by-count":74,"title":["Congenital diaphragmatic hernia with(out) ECMO: impaired development at 8 years"],"prefix":"10.1136","volume":"98","author":[{"given":"Marlous J","family":"Madderom","sequence":"first","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine and Physical Therapy, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique H M","family":"van der Cammen-van Zijp","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"},{"name":"Department of Rehabilitation Medicine and Physical Therapy, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia J","family":"Gischler","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 M H","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"IJsselstijn","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center\u2014Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"2025090512362589000_98.4.F316.1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200208000-00022"},{"key":"2025090512362589000_98.4.F316.2","doi-asserted-by":"publisher","DOI":"10.1159\/000322694"},{"key":"2025090512362589000_98.4.F316.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.03.011"},{"key":"2025090512362589000_98.4.F316.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.02.029"},{"key":"2025090512362589000_98.4.F316.5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.156158"},{"key":"2025090512362589000_98.4.F316.6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.141051"},{"key":"2025090512362589000_98.4.F316.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2624-3"},{"key":"2025090512362589000_98.4.F316.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90589-3"},{"key":"2025090512362589000_98.4.F316.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90627-8"},{"key":"2025090512362589000_98.4.F316.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90590-X"},{"key":"2025090512362589000_98.4.F316.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90685-0"},{"key":"2025090512362589000_98.4.F316.12","doi-asserted-by":"publisher","DOI":"10.1186\/cc7770"},{"key":"2025090512362589000_98.4.F316.13","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1097\/PCC.0b013e3182231872","article-title":"Prospective longitudinal evaluation of lung function during the first year of life after repair of congenital diaphragmatic hernia","volume":"13","author":"Spoel","year":"2011","journal-title":"Pediatr Crit Care Med"},{"key":"2025090512362589000_98.4.F316.14","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90591-X"},{"key":"2025090512362589000_98.4.F316.15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1167"},{"key":"2025090512362589000_98.4.F316.16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90708-2"},{"key":"2025090512362589000_98.4.F316.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.12.034"},{"key":"2025090512362589000_98.4.F316.18","doi-asserted-by":"crossref","unstructured":"Spoel M Laas R Gischler SJ . 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