{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:54:32Z","timestamp":1758477272630,"version":"3.44.0"},"reference-count":40,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2013,2,4]]},"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To test the hypothesis that a higher pulsoximetric arterial oxygen saturation (SpO<jats:sub>2<\/jats:sub>) target range is associated with reduced cerebral tissue oxygen desaturations from baseline during events of hypoxaemia or bradycardia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Randomised crossover trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Single tertiary care neonatal intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Sixteen preterm infants with severe intermittent hypoxaemia or bradycardia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>SpO<jats:sub>2<\/jats:sub> target was set to 80\u201392% and 85\u201396% for 4\u2005h each in random sequence. On a subsequent day, the target sequence was reversed and the study was repeated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>We simultaneously recorded cerebral tissue oxygen saturation (cerebral StO<jats:sub>2<\/jats:sub>), SpO<jats:sub>2<\/jats:sub> and heart rate. Cerebral StO<jats:sub>2<\/jats:sub> was measured by near infrared spectroscopy. The primary outcome was the cumulative cerebral StO<jats:sub>2<\/jats:sub> desaturation score representing the area below a cerebral StO<jats:sub>2<\/jats:sub> baseline value before onset of each hypoxaemic or bradycardic event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During low SpO<jats:sub>2<\/jats:sub> target range the median (IQR) cumulative cerebral StO<jats:sub>2<\/jats:sub> desaturation score was higher (27384 (15825\u201337396) vs 18103 (6964\u201332946), p=0.011) and the mean (\u00b1SD) number of events was higher (29.1 (\u00b115.3) vs 21.1 (\u00b111.4), p=0.001). More time was spent with SpO<jats:sub>2<\/jats:sub> below 80% (57.2 (\u00b124.8) min vs 34.0 (\u00b129.6) min, p=0.006). Total time of hyperoxaemia (defined as SpO<jats:sub>2<\/jats:sub> \u226597% and \u226599%, respectively) and total time with cerebral StO<jats:sub>2<\/jats:sub> &lt;60% and &lt;55% were similar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A lower SpO<jats:sub>2<\/jats:sub> target range was associated with a greater cumulative cerebral StO<jats:sub>2<\/jats:sub> desaturation score, caused by more frequent SpO<jats:sub>2<\/jats:sub> desaturations. However, time at very low cerebral StO<jats:sub>2<\/jats:sub> was not affected. Episodes of hyperoxaemia were not reduced.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2012-303136","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T20:50:09Z","timestamp":1362257409000},"page":"F392-F398","source":"Crossref","is-referenced-by-count":16,"title":["Cerebral desaturations in preterm infants: a crossover trial on influence of oxygen saturation target range"],"prefix":"10.1136","volume":"98","author":[{"given":"Manuel B","family":"Schmid","sequence":"first","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care, Department for Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard J","family":"Hopfner","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care, Department for Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lenhof","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care, Department for Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut D","family":"Hummler","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care, Department for Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Critical Care, Department for Pediatrics and Adolescent Medicine, University Medical Center, Ulm, 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