{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:45:48Z","timestamp":1789728348953,"version":"4.0.1"},"reference-count":13,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Objective<\/jats:title>To quantify the burden of selected congenital anomalies in low and middle-income countries (LMICs) that could be reduced should surgical programmes cover the entire population with access to quality care.<\/jats:p><\/jats:sec>Design<\/jats:title>Burden of disease and epidemiological modelling.<\/jats:p><\/jats:sec>Setting<\/jats:title>LMICs from all global regions.<\/jats:p><\/jats:sec>Population<\/jats:title>All prevalent cases of selected congenital anomalies at birth in 2010.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>Disability-adjusted life years (DALYs).<\/jats:p><\/jats:sec>Interventions and methods<\/jats:title>Surgical programmes for three congenital conditions were analysed: clefts (lip and palate); congenital heart anomalies; and neural tube defects. Data from the Global Burden of Disease 2010 Study were used to estimate the combination of fatal burden that could be addressed by surgical care and the additional long-term non-fatal burden associated with increased survival.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the estimated 21.6 million DALYs caused by these three conditions in LMICs, 12.4 million DALYs (57%) are potentially addressable by surgical care among the population born with such conditions. Neural tube defects have the largest potential with 76% of burden amenable by surgery, followed by clefts (59%) and congenital heart anomalies (49%). Sub-Saharan Africa and South Asia have the greatest proportion of surgically addressable burden for clefts (68%), North Africa and Middle East for congenital heart anomalies (73%), and South Asia for neural tube defects (81%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is an important and neglected role surgical programmes can play in reducing the burden of congenital anomalies in LMICs.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2014-306175","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T07:17:16Z","timestamp":1411802236000},"page":"233-238","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["The burden of selected congenital anomalies amenable to surgery in low and middle-income regions: cleft lip and palate, congenital heart anomalies and neural tube defects"],"prefix":"10.1136","volume":"100","author":[{"given":"Hideki","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J","family":"Barendregt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Kassebaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Bickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"key-10.1136\/archdischild-2014-306175-1","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2014-306175-2","first-page":"1330","article-title":"Epidemiology of paediatric surgical admissions to a government referral hospital in the Gambia","volume":"78","author":"Bickler","year":"2000","journal-title":"Bull World Health Organ"},{"key":"key-10.1136\/archdischild-2014-306175-3","volume-title":"Medical mission trips","author":"International Children's Heart Foundation","year":"2013"},{"key":"key-10.1136\/archdischild-2014-306175-4","unstructured":"CURE International. 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Pennsylvania: CURE International, 2013. http:\/\/cure.org\/hospitals\/uganda\/ (accessed 3 Nov 2013)."},{"key":"key-10.1136\/archdischild-2014-306175-5","author":"Smile Train","year":"2013","journal-title":"Our work around the world"},{"key":"key-10.1136\/archdischild-2014-306175-6","volume-title":"Disease control priorities in developing countries","author":"Jamison","year":"2006","edition":"2"},{"key":"key-10.1136\/archdischild-2014-306175-7","first-page":"1245","article-title":"Surgery","volume-title":"Disease control priorities in developing countries","author":"Debas","year":"2006","edition":"2"},{"key":"key-10.1136\/archdischild-2014-306175-8","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2014-306175-9","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2014-306175-10","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/S0140-6736(12)61680-8","article-title":"Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010","volume":"380","author":"Salomon","year":"2012","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2014-306175-11","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/S0140-6736(12)61899-6","article-title":"GBD 2010: design, definitions, and metrics","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2014-306175-12","volume-title":"WHO discussion paper: positioning health in the post-2015 development agenda","author":"World Health Organization","year":"2012"},{"key":"key-10.1136\/archdischild-2014-306175-13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s00268-013-2243-y","article-title":"Cost-effectiveness of surgery in low-and middle-income countries: a systematic review","volume":"38","author":"Grimes","year":"2014","journal-title":"World J Surg"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2014-306175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:37:44Z","timestamp":1601109464000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2014-306175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,26]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,2,18]]},"published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1136\/archdischild-2014-306175"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2014-306175","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,26]]}}}