{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:35:29Z","timestamp":1794278129700,"version":"4.9.0"},"reference-count":38,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Hypoglycaemia is frequent in children and prompt management is required to prevent brain injury. In this article we will consider hypoglycaemia in children after the neonatal period. The most common causes are diabetes mellitus and idiopathic ketotic hypoglycaemia (IKH) but a number of endocrine disorders and inborn errors of metabolism (IEMs) need to be excluded. Elucidation of the diagnosis relies primarily on investigations during a hypoglycaemic episode but may also involve biochemical tests between episodes, dynamic endocrine tests and molecular genetics. Specific treatment such as cortisol replacement and pancreatic surgery may be required for endocrine causes of hypoglycaemia, such as adrenal insufficiency and congenital hyperinsulinism. In contrast, in IKH and most IEMs, hypoglycaemia is prevented by limiting the duration of fasting and maintaining a high glucose intake during illnesses.<\/jats:p>","DOI":"10.1136\/archdischild-2015-308337","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T03:18:54Z","timestamp":1451531934000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Recognition, assessment and management of hypoglycaemia in childhood"],"prefix":"10.1136","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-8693","authenticated-orcid":false,"given":"Arunabha","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indraneel","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A M","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"issue":"(Suppl. 3)","key":"key-10.1136\/archdischild-2015-308337-1","first-page":"530","article-title":"Hypoglycemia in childhood: long-term effects","volume":"1","author":"Kanaka-Gantenbein","year":"2004","journal-title":"Pediatr Endocrinol Rev"},{"key":"key-10.1136\/archdischild-2015-308337-2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jpeds.2015.02.045","article-title":"Re-evaluating \u201ctransitional neonatal hypoglycemia\u201d: mechanism and implications for management","volume":"166","author":"Stanley","year":"2015","journal-title":"J Pediatr"},{"key":"key-10.1136\/archdischild-2015-308337-3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/archdischild-2015-308336","article-title":"What is a normal blood glucose?","volume":"101","author":"G\u00fcemes","year":"2016","journal-title":"Arch Dis Child"},{"key":"key-10.1136\/archdischild-2015-308337-4","first-page":"19","article-title":"Insulin and Insulin Resistance","volume":"26","author":"Wilcox","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"key-10.1136\/archdischild-2015-308337-5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1023\/A:1005675827612","article-title":"Genetic hypoglycaemia in infancy and childhood: pathophysiology and diagnosis","volume":"23","author":"Saudubray","year":"2000","journal-title":"J Inherit Metab Dis"},{"key":"key-10.1136\/archdischild-2015-308337-6","first-page":"463","article-title":"Glucose counterregulatory responses to hypoglycemia","volume":"9","author":"Sprague","year":"2011","journal-title":"Pediatr Endocrinol Rev"},{"key":"key-10.1136\/archdischild-2015-308337-7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1172\/JCI31669","article-title":"Hypoglycemia, functional brain failure, and brain death","volume":"117","author":"Cryer","year":"2007","journal-title":"J Clin Invest"},{"key":"key-10.1136\/archdischild-2015-308337-8","unstructured":"National Metabolic Biochemistry Network. 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