{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:39:25Z","timestamp":1790501965704,"version":"4.1.0"},"reference-count":39,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2015,10,11]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the value of neonatal EEG for predicting non-optimal neurodevelopmental outcomes in very preterm infants, using a multimodal strategy of evaluation comprising brain imaging and clinical assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Between 2003 and 2009, we performed an observational, population-based study. Out of 2040 eligible preterm infants born before 32\u2005weeks, 1954 were enrolled in the French regional Loire Infant Follow-Up Team (LIFT) cohort. 1744 (89%) of these completed the follow-up. Neonatal EEGs were recorded prospectively as two EEGs during the first 2\u2005weeks of life and then one every 2\u2005weeks up to 33\u2005weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The neurodevelopmental outcome was assessed by physical examination, the Brunet\u2013L\u00e9zine Test and\/or the Age and Stages Questionnaire at 2\u2005years of corrected age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1744 infants assessed at 2\u2005years, 422 had a non-optimal outcome. A total of 4804 EEGs were performed, and 1345 infants had at least one EEG. EEG abnormalities were predictive of non-optimal outcomes after controlling for confounding factors such as severe intracranial lesions detected by brain imaging. Transient moderate and severe abnormalities were independent predictors of non-optimal outcomes with an OR and 95% CI of 1.49 (1.08 to 2.04) and 2.38 (1.49 to 3.81), respectively. In the validation group, the predictive risk stratification tree identified severe abnormalities as a factor contributing to the prognosis of two subgroups: infants with severe cranial lesions and infants with a normal examination at discharge and without severe cranial lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/archdischild-2015-308664","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T20:25:58Z","timestamp":1446236758000},"page":"F253-F259","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Neonatal EEG and neurodevelopmental outcome in preterm infants born before 32\u2005weeks"],"prefix":"10.1136","volume":"101","author":[{"given":"Maximilien","family":"P\u00e9rivier","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Roz\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France"},{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Gascoin","sequence":"additional","affiliation":[{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Department of Neonatal Medicine, Angers University, University Hospital of Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Hanf","sequence":"additional","affiliation":[{"name":"Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Branger","sequence":"additional","affiliation":[{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Rouger","sequence":"additional","affiliation":[{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Berlie","sequence":"additional","affiliation":[{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Department of Pediatric Neurology, Angers University, University Hospital of Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Montcho","sequence":"additional","affiliation":[{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Department of Neonatal Medicine, Hospital of Le Mans, Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"P\u00e9r\u00e9on","sequence":"additional","affiliation":[{"name":"Laboratoire d'Explorations Fonctionnelles, Nantes University, Centre de R\u00e9f\u00e9rence Maladies Neuromusculaires Nantes-Angers, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Flamant","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France"},{"name":"\u2018Loire Infant Follow-up Team\u2019 (LIFT) Network, Nantes, Pays de Loire, France"},{"name":"Clinical 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