{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:22:31Z","timestamp":1761513751873,"version":"3.44.0"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2015,12,4]]},"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The outcome of a pregnancy following identification of a sex chromosome abnormality (SCA) is unclear. The aims of this study were to ascertain the prevalence of SCA detected prenatally in Scotland and to determine the outcomes for these cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Following retrospective identification of all prenatal karyotypes performed in Scotland between 2000 and 2012, data linkage was performed to obtain information regarding maternal characteristics and pregnancy outcomes. Detailed outcome data were also collected for all affected offspring in the West of Scotland and Grampian regions within Scotland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 28\u2005145 pregnancies that had a karyotype over the study period, records were available for 27\u2005152 (96%). Karyotype abnormalities were identified in 2139 (8%), with SCA being identified in 321(1%) tests. 45,X was identified as the commonest SCA in 135 pregnancies. Of 121 pregnancies with SCA in the West of Scotland and Grampian, 64 (53%), 52 (43%) and 5 (4%) led to a live birth, termination and intrauterine death, respectively. Of the 64 live births, 21 (33%) had a postnatal karyotype and 35 (54%) received specialist follow-up for the SCA that was identified prenatally.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Abnormalities of sex chromosomes are identified in approximately 1% of all pregnancies that undergo a prenatal karyotype. There is a need to review the prenatal as well as postnatal care of the affected mother and offspring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2015-309681","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T23:34:04Z","timestamp":1452728044000},"page":"F423-F427","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["The outcome of prenatal identification of sex chromosome abnormalities"],"prefix":"10.1136","volume":"101","author":[{"given":"Angela K","family":"Lucas-Herald","sequence":"first","affiliation":[{"name":"Developmental Endocrinology Research Group, University of Glasgow, RHC, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Cann","sequence":"additional","affiliation":[{"name":"North of Scotland Regional Genetics Service, Clinical Genetics Centre, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Crawford","sequence":"additional","affiliation":[{"name":"Cytogenetics Department, West of Scotland Genetics Laboratory, Southern General Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Southern General Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoud","family":"Boroujerdi","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group, University of Glasgow, RHC, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M","family":"Nelson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Faisal","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group, University of Glasgow, RHC, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Southern General Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"2025090512555298000_101.5.F423.1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1721"},{"key":"2025090512555298000_101.5.F423.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"2025090512555298000_101.5.F423.3","doi-asserted-by":"publisher","DOI":"10.5734\/JGM.2012.9.1.17"},{"key":"2025090512555298000_101.5.F423.4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.035907"},{"key":"2025090512555298000_101.5.F423.5","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31822e57a7"},{"key":"2025090512555298000_101.5.F423.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7022.16"},{"key":"2025090512555298000_101.5.F423.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04076.x"},{"key":"2025090512555298000_101.5.F423.8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2918"},{"key":"2025090512555298000_101.5.F423.9","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1059"},{"key":"2025090512555298000_101.5.F423.10","doi-asserted-by":"publisher","DOI":"10.1159\/000106375"},{"key":"2025090512555298000_101.5.F423.11","unstructured":"National Recods of Scotland. 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