{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:25Z","timestamp":1762875745091,"version":"3.37.3"},"reference-count":20,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Children with type 1 diabetes mellitus (T1DM) are at increased risk of coeliac disease (CD). Recent guidelines indicate coeliac screening should include HLA typing for CD predisposing (DQ2\/DQ8) alleles and those negative for these alleles require no further coeliac screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (n=176) with T1DM attending clinics across two Scottish regions were screened for HLA DQ2\/DQ8 as part of routine screening. Data collected included the frequency of DQ2\/DQ8 genotypes and the additional cost of HLA screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, DQ2\/DQ8 alleles were identified in 94% of patients. The additional cost of HLA typing was \u00a33699.52 (\u00a321.02 per patient). All patients with known CD (11\/176) were positive for DQ2\/DQ8 and all were diagnosed with CD within 5\u2005years of T1DM diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The vast majority of children with T1DM have CD-predisposing HLA genotypes limiting the number of patients that can be excluded from further screening. We conclude that HLA genotyping is not currently indicated for CD screening in this population.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2015-309754","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T03:18:54Z","timestamp":1451531934000},"page":"230-233","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?"],"prefix":"10.1136","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-3765","authenticated-orcid":false,"given":"R 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