{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:39:34Z","timestamp":1784126374504,"version":"3.55.0"},"reference-count":5,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Poor growth and delayed puberty in children with cerebral palsy is frequently felt to be related to malnutrition. Although growth hormone deficiency is commonly described in these children, multiple pituitary hormone deficiency (MPHD) has not been previously reported. We present a series of four children with cerebral palsy who were born before 29\u2005weeks gestation who were referred to the regional endocrinology service, three for delayed puberty and one for short stature, in whom investigations identified MPHD. All patients had a height well below \u22122 standard deviation score (2nd centile) at presentation and three who had MRI scans had an ectopic posterior pituitary gland. We therefore recommend that the possibility of MPHD should be considered in all children with cerebral palsy and poor growth or delayed puberty. Early diagnosis and treatment is essential to maximise growth and prevent associated morbidity and mortality.<\/jats:p>","DOI":"10.1136\/archdischild-2016-311012","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T02:33:38Z","timestamp":1477622018000},"page":"559-561","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Hypopituitarism in children with cerebral palsy"],"prefix":"10.1136","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-0734","authenticated-orcid":false,"given":"Suma","family":"Uday","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Krone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"key-10.1136\/archdischild-2016-311012-1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0002-8223(96)00188-5","article-title":"Pattern of growth in children with cerebral palsy","volume":"96","author":"Krick","year":"1996","journal-title":"J Am Diet Assoc"},{"key":"key-10.1136\/archdischild-2016-311012-2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ejhg.2009.125","article-title":"Septo-optic dysplasia","volume":"18","author":"Webb","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"key-10.1136\/archdischild-2016-311012-3","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1515\/jpem-2013-0026","article-title":"Clinical characteristics and management of cranial diabetes insipidus in infants","volume":"26","author":"Karthikeyan","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key-10.1136\/archdischild-2016-311012-4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2265.2008.03236.x","article-title":"Associations with multiple pituitary hormone deficiency in patients with an ectopic posterior pituitary gland","volume":"69","author":"Murray","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.1136\/archdischild-2016-311012-5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000207479","article-title":"Developmental abnormalities of the posterior pituitary gland","volume":"14","author":"di Iorgi","year":"2009","journal-title":"Endocr Dev"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2016-311012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:41:03Z","timestamp":1601167263000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2016-311012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,5,23]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1136\/archdischild-2016-311012"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2016-311012","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}