{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:14:46Z","timestamp":1780625686220,"version":"3.54.1"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2016,11,29]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the time taken by preterm infants with evolving chronic lung disease to achieve full oral feeding when supported with humidified high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Single centre randomised controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Level III neonatal intensive care unit at the Coombe Women and Infants University Hospital, Dublin, Ireland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Very low birthweight (birth weight &lt;1500\u2005g) infants born before 30\u2005weeks' gestation who were NCPAP-dependent at 32\u2005weeks corrected gestational age were eligible to participate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Enrolled infants were randomised in a 1:1 ratio to receive HFNC or NCPAP. Participants were monitored daily until full oral feeding was established and the baby was off respiratory support.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Our primary outcome was the number of days taken to establish full oral feeds (defined as oral intake \u2265120\u2005mL\/kg\/day) from the time of randomisation. We estimated that enrolling 44 subjects (22 in each group) would allow us demonstrate a 7-day difference in our primary outcome with 80% power and \u03b1 of 5%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-four infants were randomised (22 to HFNC vs 22 to NCPAP). The mean time to achieve full oral feeding was not different between the groups (HFNC 36.5 (\u00b118.2)\u2005days vs NCPAP 34.1 (\u00b111.2)\u2005days, p=0.61).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Preterm infants treated with HFNC did not achieve full oral feeding more quickly than infants treated with NCPAP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>ISRCTN66716753.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2016-311388","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T14:40:34Z","timestamp":1482590434000},"page":"F329-F332","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["High flow nasal cannula versus NCPAP, duration to full oral feeds in preterm infants: a randomised controlled trial"],"prefix":"10.1136","volume":"102","clinical-trial-number":[{"clinical-trial-number":"isrctn66716753","registry":"10.18810\/isrctn"}],"author":[{"given":"Sinead J","family":"Glackin","sequence":"first","affiliation":[{"name":"Department of Neonatology, Coombe Women and Infants University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Coombe Women and Infants University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherly","family":"George","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Coombe Women and Infants University Hospital, Dublin, Ireland"},{"name":"UCD School of Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Semberova","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Coombe Women and Infants University Hospital, Dublin, Ireland"},{"name":"Institute for the Care of Mother and Child, Prague, Czech\u00a0Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Miletin","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Coombe Women and Infants University Hospital, Dublin, Ireland"},{"name":"UCD School of Medicine, University College Dublin, Dublin, Ireland"},{"name":"Institute for the Care of Mother and Child, Prague, Czech\u00a0Republic"},{"name":"3rd Faculty of Medicine, Charles University, Prague, Czech\u00a0Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"2025090510224497000_102.4.F329.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0738"},{"key":"2025090510224497000_102.4.F329.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300071"},{"key":"2025090510224497000_102.4.F329.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0957"},{"key":"2025090510224497000_102.4.F329.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.016"},{"key":"2025090510224497000_102.4.F329.5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23022"},{"key":"2025090510224497000_102.4.F329.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211561"},{"key":"2025090510224497000_102.4.F329.7","doi-asserted-by":"publisher","DOI":"10.5385\/jksn.2011.18.2.293"},{"key":"2025090510224497000_102.4.F329.8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309683"},{"key":"2025090510224497000_102.4.F329.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9586-x"},{"key":"2025090510224497000_102.4.F329.10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2742"},{"key":"2025090510224497000_102.4.F329.11","first-page":"1","article-title":"A controlled clinical trial of effects of water mist on obstructive respiratory signs, death rate and necropsy findings among premature infants","volume":"17","author":"Silverman","year":"1956","journal-title":"Pediatrics"},{"key":"2025090510224497000_102.4.F329.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"2025090510224497000_102.4.F329.13","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304629"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2016-311388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:40:01Z","timestamp":1757094001000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2016-311388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,6,21]]},"published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1136\/archdischild-2016-311388"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2016-311388","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}