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However, the methods for identifying pregnant women who should receive IAP and how to reduce late-onset GBS disease are not without controversy and are challenging for most sub-Saharan African countries. GBS vaccines are approaching phase III trials but are still under development. This review aims to explore the current evidence related to strategies for reducing invasive GBS disease in an African setting, the development of a GBS vaccine and whether preventative measures against GBS disease can be practically implemented.<\/jats:p>","DOI":"10.1136\/archdischild-2016-311419","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T03:14:25Z","timestamp":1476846865000},"page":"72-77","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Challenges in reducing group B <i>Streptococcus<\/i> disease in African settings"],"prefix":"10.1136","volume":"102","author":[{"given":"Yo","family":"Nishihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyaad","family":"Dangor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabir","family":"Madhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Heyderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"key-10.1136\/archdischild-2016-311419-1","volume-title":"Levels & trends in child mortality: report 2014","author":"The United Nations Inter-agency Group for Child Mortality Estimation (UN IGME)","year":"2014"},{"key":"key-10.1136\/archdischild-2016-311419-2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(14)60497-9","article-title":"Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Wang","year":"2014","journal-title":"Lancet"},{"key":"key-10.1136\/archdischild-2016-311419-3","unstructured":"World Health Organization Global Health Observatory. 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