{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:11:46Z","timestamp":1792660306525,"version":"4.5.0"},"reference-count":48,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,9,14]]},"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the association between SpO<jats:sub>2<\/jats:sub> at 5\u2009min and preterm infant outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Data from 768 infants &lt;32 weeks gestation from 8 randomised controlled trials (RCTs) of lower (\u22640.3) versus higher (\u22650.6) initial inspiratory fractions of oxygen (FiO<jats:sub>2<\/jats:sub>) for resuscitation, were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Individual patient analysis of 8 RCTs<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Lower (\u22640.3) versus higher (\u22650.6) oxygen resuscitation strategies targeted to specific predefined SpO<jats:sub>2<\/jats:sub> before 10\u2009min of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Infants &lt;32 weeks gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Relationship between SpO<jats:sub>2<\/jats:sub> at 5\u2009min, death and intraventricular haemorrhage (IVH) &gt;grade 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>5\u2009min SpO<jats:sub>2<\/jats:sub> data were obtained from 706 (92%) infants. Only 159 (23%) infants met SpO<jats:sub>2<\/jats:sub> study targets and 323 (46%) did not reach SpO<jats:sub>2<\/jats:sub>80%. Pooled data showed decreased likelihood of reaching SpO<jats:sub>2<\/jats:sub>80% if resuscitation was initiated with FiO<jats:sub>2<\/jats:sub> &lt;0.3 (OR 2.63, 95% CI 1.21 to 5.74, p&lt;0.05). SpO<jats:sub>2<\/jats:sub> &lt;80% was associated with lower heart rates (mean difference \u22128.37, 95%\u2009CI \u221215.73 to \u20131.01, *p&lt;0.05) and after accounting for confounders, with IVH (OR 2.04, 95%\u2009CI 1.01 to 4.11, p&lt;0.05). Bradycardia (heart rate &lt;100\u2009bpm) at 5\u2009min increased risk of death (OR 4.57, 95%\u2009CI 1.62 to 13.98, p&lt;0.05). Taking into account confounders including gestation, birth weight and 5\u2009min bradycardia, risk of death was significantly increased with time taken to reach SpO<jats:sub>2<\/jats:sub>80%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Not reaching SpO<jats:sub>2<\/jats:sub>80% at 5\u2009min is associated with adverse outcomes, including IVH. Whether this is because of infant illness or the amount of oxygen that is administered during stabilisation is uncertain and needs to be examined in randomised trials<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2016-312366","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T20:11:22Z","timestamp":1507407082000},"page":"F446-F454","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":156,"title":["Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants"],"prefix":"10.1136","volume":"103","author":[{"given":"Ju Lee","family":"Oei","sequence":"first","affiliation":[{"name":"Department of Newborn Care, The Royal Hospital for Women, Randwick, New South Wales, Australia"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Randwick, New South Wales, Australia"},{"name":"Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil N","family":"Finer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology, University of California, San Diego, California, USA"},{"name":"Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research, The University of Oslo, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Wright","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute and Graduate Medicine, The University of Wollongong, Wollongong, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacov","family":"Rabi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Calgary, Alberta, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Tarnow-Mordi","sequence":"additional","affiliation":[{"name":"Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Rich","sequence":"additional","affiliation":[{"name":"Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Rook","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology, Erasmus Medical Centre, Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Smyth","sequence":"additional","affiliation":[{"name":"Department of Newborn Care, The Royal Hospital for Women, Randwick, New South Wales, Australia"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Newborn Care, The Royal Hospital for Women, Randwick, New South Wales, Australia"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-4742","authenticated-orcid":false,"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,10,7]]},"reference":[{"key":"2025090512273150000_103.5.F446.1","unstructured":"Neonatal Resuscitation Program Part 13. 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