{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:14:25Z","timestamp":1791465265685,"version":"4.3.4"},"reference-count":33,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,5,2]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to identify gestational-age corrected prenatal ultrasound markers of complex gastroschisis, and to compare physical growth and neurodevelopment between children with simple and complex gastroschisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We included prenatally diagnosed gastroschisis patients from 2000 to 2012 who joined our longitudinal follow-up programme. Associations between complex gastroschisis and prenatal ultrasound markers collected at 30 weeks\u2019 gestation and prior to delivery were tested using logistic regression. Physical growth (SD scores (SDS)), mental and psychomotor developmental index (MDI, PDI; Bayley Scales of Infant Development) were recorded at 12 and 24 months. Data were analysed using general linear models and compared with population norms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data of 61 children were analysed (82% of eligible cases). Extra-abdominal bowel dilatation at 30 weeks\u2019 gestation was significantly associated with complex gastroschisis (OR (95%\u2009CI): 5.00 (1.09 to 22.98)), with a high negative (88%) but low positive (40%) predictive value. The mean (95%\u2009CI) height SDS at 12 months (\u22120.46 (\u20130.82 to \u20130.11)), and weight SDS at 12 and 24 months (\u22120.45 (\u20130.85 to \u20130.05), and \u22120.44 (\u22120.87 to \u20130.01), respectively) fell significantly below 0 SDS. MDI and PDI were significantly below 100 at 24 months; 93 (88 to 99) and 83 (78 to 87), respectively). Children with complex gastroschisis had a significantly lower PDI (76 (68 to 84)) than those with simple gastroschisis (94 (90 to 97), p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prenatal ultrasound markers could not reliably distinguish between simple and complex gastroschisis. Children with complex gastroschisis may be at increased risk for delayed psychomotor development; they should be monitored more closely, and offered timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/archdischild-2016-312417","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T21:00:12Z","timestamp":1497474012000},"page":"F126-F131","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Prenatal markers and longitudinal follow-up in simple and complex gastroschisis"],"prefix":"10.1136","volume":"103","author":[{"given":"Annelieke","family":"Hijkoop","sequence":"first","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery, Erasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"IJsselstijn","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery, Erasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 M H","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery, Erasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery, Erasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost van","family":"Rosmalen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titia E","family":"Cohen-Overbeek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"2025090511261336000_103.2.F126.1","unstructured":"EUROCAT prevalence data tables. 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