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An empiric trial of proton pump inhibitors can help individual children with undiagnosed respiratory symptoms and suspicion of GORD, but the response to therapy is unpredictable, and in any case what may be being observed is spontaneous improvement. Furthermore, the safety of these agents has been called into question. Poor response to antireflux therapy is an important trigger to search for non-gastro-oesophageal reflux causes for patients\u2019 symptoms. Evidence for the assessment of children with suspected extraoesophageal manifestations of GORD is scanty and longitudinal studies with long-term follow-up are urgently required.<\/jats:p>","DOI":"10.1136\/archdischild-2017-312890","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:50:23Z","timestamp":1504831823000},"page":"292-296","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Respiratory manifestations of gastro-oesophageal reflux in children"],"prefix":"10.1136","volume":"103","author":[{"given":"Fernando Maria","family":"de Benedictis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"2020050712435347000_103.3.292.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000361306.15727.54"},{"key":"2020050712435347000_103.3.292.2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.69"},{"key":"2020050712435347000_103.3.292.3","first-page":"w13544","article-title":"Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain","volume":"142","author":"Saritas Yuksel","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"2020050712435347000_103.3.292.4","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12231"},{"key":"2020050712435347000_103.3.292.5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.gtc.2013.11.007","article-title":"Extraesophageal presentations of GERD: Where is the science?","volume":"43","author":"Madanick","year":"2014","journal-title":"Gastroenterol Clin N Am"},{"key":"2020050712435347000_103.3.292.6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/SLA.0000000000001907","article-title":"Diagnosis and treatment of the extraesophageal manifestations of gastroesophageal reflux disease","volume":"265","author":"Sidhwa","year":"2017","journal-title":"Ann Surg"},{"key":"2020050712435347000_103.3.292.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"2020050712435347000_103.3.292.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"2020050712435347000_103.3.292.9","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-142"},{"key":"2020050712435347000_103.3.292.10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2382"},{"key":"2020050712435347000_103.3.292.11","first-page":"24","article-title":"Gastroesophageal reflux disease and childhood asthma","volume":"19","author":"Blake","year":"2013","journal-title":"Curr Opin Pulm Med"},{"key":"2020050712435347000_103.3.292.12","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.129"},{"key":"2020050712435347000_103.3.292.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2035"},{"key":"2020050712435347000_103.3.292.14","doi-asserted-by":"publisher","DOI":"10.1136\/thx.40.8.592"},{"key":"2020050712435347000_103.3.292.15","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328332ca2f"},{"key":"2020050712435347000_103.3.292.16","doi-asserted-by":"crossref","first-page":"45S","DOI":"10.1016\/S0002-9343(03)00192-X","article-title":"Reflex mechanisms in gastroesophageal reflux disease and asthma","volume":"115 Suppl 3A","author":"Canning","year":"2003","journal-title":"Am J Med"},{"key":"2020050712435347000_103.3.292.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2008.10.013"},{"key":"2020050712435347000_103.3.292.18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.7.506"},{"key":"2020050712435347000_103.3.292.19","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207662"},{"key":"2020050712435347000_103.3.292.20","first-page":"91","article-title":"Problematic severe asthma in children: the Pandora\u2019 box","volume":"7","author":"de Benedictis","year":"2011","journal-title":"Eur Respir Dis"},{"key":"2020050712435347000_103.3.292.21","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802fe89c"},{"key":"2020050712435347000_103.3.292.22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4292\/wjgpt.v7.i4.531","article-title":"Widespread use of gastric acid inhibitors in infants: are they needed? 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