{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:55:12Z","timestamp":1774680912542,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,8,4]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO<jats:sub>2<\/jats:sub> partial pressure (pCO<jats:sub>2<\/jats:sub>) in premature infants more effectively than non-invasive continuous positive airway pressure (nCPAP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Non-blinded prospective randomised controlled cross-over study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>University Medical Center tertiary neonatal intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>26 premature infants of 27\u00b12 weeks of gestational age after extubation or non-invasive surfactant treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Infants were treated with 4\u2009hours of nHFOV and 4\u2009hours of nCPAP in a cross-over design. The sequence of the ventilation mode was randomly allocated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The primary outcome measure was pCO<jats:sub>2<\/jats:sub> of arterial or arterialised blood 4\u2009hours after commencing the respective mode of respiratory support. Secondary outcome criteria included events of apnoea and bradycardia, respiratory rate, heart rate, pain and\/or discomfort, mean airway pressure, fraction of inspired oxygen and failure of non-invasive respiratory support.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>pCO<jats:sub>2<\/jats:sub> after 4\u2009hours of nHFOV was similar compared with 4\u2009hours of nCPAP (p=0.33). pCO<jats:sub>2<\/jats:sub> was 54.8 (14.6) vs 52.7 (9.3) mm Hg mean (SD) for the nHFOV\u2013nCPAP period (n=13) and 49.0 (8.1) vs 47.7 (9.5) mm Hg for the nCPAP\u2013nHFOV period (n=13). There was no difference in any of the secondary outcome measures. nHFOV was terminated prematurely in five cases for predefined failure criteria (p=0.051).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We could not demonstrate an increased carbon dioxide clearance applying nHFOV compared with nCPAP in this cohort of preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>DRKS00007171, results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2017-313190","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T20:25:31Z","timestamp":1505593531000},"page":"F1-F5","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Non-invasive high-frequency oscillatory ventilation in preterm infants: a randomised controlled cross-over trial"],"prefix":"10.1136","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-3866","authenticated-orcid":false,"given":"Daniel","family":"Klotz","sequence":"first","affiliation":[{"name":"Department of Neonatology, Center for Pediatrics, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendryk","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Center for Pediatrics, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schumann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Center for Pediatrics, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"2025090221244131000_103.4.F1.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1880"},{"key":"2025090221244131000_103.4.F1.2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.siny.2016.02.001","article-title":"High-frequency ventilation for non-invasive respiratory support of neonates","volume":"21","author":"Yoder","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"key":"2025090221244131000_103.4.F1.3","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0889"},{"key":"2025090221244131000_103.4.F1.4","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.1.F61"},{"key":"2025090221244131000_103.4.F1.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00900.x"},{"key":"2025090221244131000_103.4.F1.6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0034-1381317","article-title":"Use of noninvasive high-frequency ventilation in the neonatal intensive care unit: a retrospective review","volume":"30","author":"Mukerji","year":"2015","journal-title":"Am J Perinatol"},{"key":"2025090221244131000_103.4.F1.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2419-y"},{"key":"2025090221244131000_103.4.F1.8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310664"},{"key":"2025090221244131000_103.4.F1.9","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.1.F36"},{"key":"2025090221244131000_103.4.F1.10","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2012.0276"},{"issue":"Suppl 1","key":"2025090221244131000_103.4.F1.11","first-page":"1","article-title":"Anwendung von nasalem HFOV bei Fr\u00fchgeborenen: Ergebniss einer retrospektiven Analyse","volume":"163","author":"Stavropolou","year":"2015","journal-title":"Monatsschr Kinderheilkd"},{"key":"2025090221244131000_103.4.F1.12","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmv088"},{"key":"2025090221244131000_103.4.F1.13","first-page":"49","article-title":"Non-invasive high-frequency ventilation versus bi-phasic continuous positive airway pressure (BP-CPAP) following CPAP failure in infants","volume":"37","author":"Mukerji","year":"2017","journal-title":"J Perinatol Off J Calif Perinat Assoc"},{"key":"2025090221244131000_103.4.F1.14","doi-asserted-by":"crossref","unstructured":"Cools F , Offringa M , Askie LM . 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Cochrane Database Syst Rev 2015:CD000104.doi:10.1002\/14651858.CD000104.pub4","DOI":"10.1002\/14651858.CD000104.pub4"},{"key":"2025090221244131000_103.4.F1.15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/ppul.23534","article-title":"Leakage in nasal high-frequency oscillatory ventilation improves carbon dioxide clearance\u2014a bench study","volume":"52","author":"Klotz","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"2025090221244131000_103.4.F1.16","doi-asserted-by":"publisher","DOI":"10.1159\/000431216"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2017-313190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:24:49Z","timestamp":1756873489000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2017-313190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,16]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,6,19]]},"published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1136\/archdischild-2017-313190"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2017-313190","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,16]]}}}