{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:00Z","timestamp":1787016900573,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,8,10]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9\u2009hours (IQR 5\u201313) due to rapid clinical improvement. Five (50%) had injury on MRI or spectroscopy, and two (20%) had an abnormal neurodevelopmental outcome at 2 years. Premature cessation of cooling therapy in babies with mild neonatal encephalopathy does not exclude residual brain injury and adverse long-term neurodevelopmental outcomes. This study refers to babies recruited into the MARBLE study (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT01309711\">NCT01309711<\/jats:ext-link>\n                    , pre-results stage).\n                  <\/jats:p>","DOI":"10.1136\/archdischild-2017-313321","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T20:50:21Z","timestamp":1506027021000},"page":"F383-F387","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy"],"prefix":"10.1136","volume":"103","clinical-trial-number":[{"clinical-trial-number":"nct01309711","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-0103","authenticated-orcid":false,"given":"Peter J","family":"Lally","sequence":"first","affiliation":[{"name":"Centre for Perinatal Neuroscience, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Montaldo","sequence":"additional","affiliation":[{"name":"Centre for Perinatal Neuroscience, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centre for Perinatal Neuroscience, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Shankar","family":"Swamy","sequence":"additional","affiliation":[{"name":"Centre for Perinatal Neuroscience, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung","family":"Soe","sequence":"additional","affiliation":[{"name":"Oliver Fisher Neonatal Unit, Medway Maritime Hospital, Kent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetha","family":"Shankaran","sequence":"additional","affiliation":[{"name":"Department of Neonatal Perinatal Medicine, Wayne State University, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhin","family":"Thayyil","sequence":"additional","affiliation":[{"name":"Centre for Perinatal Neuroscience, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"2025090503574618000_103.4.F383.1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jpc.13378","article-title":"Eligibility criteria for therapeutic hypothermia: From trials to clinical practice","volume":"53","author":"Mehta","year":"2017","journal-title":"J Paediatr Child Health"},{"key":"2025090503574618000_103.4.F383.2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-008912","article-title":"Magnetic Resonance Biomarkers in Neonatal Encephalopathy (MARBLE): a prospective multicountry study","volume":"5","author":"Lally","year":"2015","journal-title":"BMJ Open"},{"key":"2025090503574618000_103.4.F383.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"2025090503574618000_103.4.F383.4","unstructured":"BAPM\/RCPCH Working Group (2008). Classification of health status at 2 years as a perinatal outcome. http:\/\/www.bapm.org\/publications\/documents\/guidelines\/Outcome BAPM WG_report_v6_Jan08.pdf (accessed 25 Jun 2017)."},{"key":"2025090503574618000_103.4.F383.5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jpeds.2017.03.065","article-title":"The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy","volume":"187","author":"Walsh","year":"2017","journal-title":"J Pediatr"},{"key":"2025090503574618000_103.4.F383.6","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318212020a"},{"key":"2025090503574618000_103.4.F383.7","doi-asserted-by":"crossref","unstructured":"Davidson JO , Draghi V , Whitham S , et al . How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep? J Cereb Blood Flow Metab 2017:0271678X1770767.doi:10.1177\/0271678X17707671","DOI":"10.1177\/0271678X17707671"},{"key":"2025090503574618000_103.4.F383.8","first-page":"667","article-title":"Effect of therapeutic hypothermia on C-reactive protein levels in patients with perinatal asphyxia","volume":"32","author":"Okumu\u015f","year":"2015","journal-title":"Am J Perinatol"},{"key":"2025090503574618000_103.4.F383.9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000455838","article-title":"Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent","volume":"39","author":"Falck","year":"2017","journal-title":"Dev Neurosci"},{"key":"2025090503574618000_103.4.F383.10","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0659","article-title":"Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy","volume":"138","author":"Murray","year":"2016","journal-title":"Pediatrics"},{"key":"2025090503574618000_103.4.F383.11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/pr.2017.75","article-title":"Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia","volume":"82","author":"Koo","year":"2017","journal-title":"Pediatr Res"},{"key":"2025090503574618000_103.4.F383.12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroscience.2015.12.046","article-title":"White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy","volume":"316","author":"Wang","year":"2016","journal-title":"Neuroscience"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2017-313321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:57:54Z","timestamp":1757069874000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2017-313321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,6,19]]},"published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1136\/archdischild-2017-313321"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2017-313321","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}