{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:08:29Z","timestamp":1788930509486,"version":"build-2803163510"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Educ Pract Ed"],"accepted":{"date-parts":[[2017,10,9]]},"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Congenital heart disease (CHD) remains a leading cause of infant mortality, which is even higher in infants with undiagnosed duct-dependent CHDs. Up to 39%\u201350% of infants with critical CHD are being discharged undiagnosed from the hospital. Infants with duct-dependent critical CHD remain well during the fetal period and may deteriorate when the ductus arteriosus (commonly called \u2018duct\u2019) closes after birth. It is critical to open or maintain ductus arteriosus patent in infants with duct-dependent CHDs. Prostaglandin E1 (alprostadil marketed as \u2018Prostin VR \u2019) and prostaglandin E2 (dinoprostone) are used to maintain a patent ductus arteriosus and the dose of medication depends on the clinical presentation. Delay in starting prostaglandin infusion can have deleterious effects on infants and can even lead to death. These infants often present as an emergency, and professionals caring for these infants need to have a good understanding of these conditions and medications used for ductal patency.<\/jats:p>","DOI":"10.1136\/archdischild-2017-313654","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T20:40:32Z","timestamp":1511296832000},"page":"137-140","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Use of prostaglandins in duct-dependent congenital heart conditions"],"prefix":"10.1136","volume":"103","author":[{"given":"Yogen","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Neonatology and Paediatric Cardiology, Cambridge University Hospitals NHS Foundation Trust and University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Mikrou","sequence":"additional","affiliation":[{"name":"Health Education England (West Midlands), Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"2025090501290847000_103.3.137.1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.71.3.F179"},{"key":"2025090501290847000_103.3.137.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00295.x"},{"key":"2025090501290847000_103.3.137.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0981-9"},{"key":"2025090501290847000_103.3.137.4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2217\/fca.12.15","article-title":"Fetal cardiac screening and variation in prenatal detection rates of congenital heart disease: why bother with screening at all?","volume":"8","author":"Sharland","year":"2012","journal-title":"Future Cardiol"},{"key":"2025090501290847000_103.3.137.5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.096305"},{"key":"2025090501290847000_103.3.137.6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S1047951113001522","article-title":"Efficacy of very low-dose prostaglandin E1 in duct-dependent congenital heart disease","volume":"25","author":"Yucel","year":"2015","journal-title":"Cardiol Young"},{"issue":"Suppl","key":"2025090501290847000_103.3.137.7","first-page":"1529","article-title":"Evaluation of infusion protaglandin (PGE2) versus infusion prostaglandin e1 (PGE1) in management of duct-dependent pulmonary circulation congenital heart disease","volume":"15","author":"Zainal Abidin","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"2025090501290847000_103.3.137.8","article-title":"Effectiveness of alprostadil dose titration in neonates with congenital heart disease","volume":"32","author":"Buck","year":"2012","journal-title":"Pharmacotherapy"},{"key":"2025090501290847000_103.3.137.9","unstructured":"Regional guideline on the use of alprostadil in duct-dependent congenital heart conditions in neonates. Yorkshire and humber neonatal network and yorkshire paediatric congenital cardiac network, 2015."},{"key":"2025090501290847000_103.3.137.10","unstructured":"Prostaglandin infusion Guideline . South West Midlands neonatal network, 2015-2017."},{"key":"2025090501290847000_103.3.137.11","unstructured":"British Medical Association. BNF for children. 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