{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:42Z","timestamp":1792103922281,"version":"4.4.0"},"reference-count":40,"publisher":"BMJ","issue":"5","funder":[{"name":"Red Nose Australia"},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2018,9,22]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3\u2009days of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Case\u2013control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Neonatal intensive care unit of the Wilhelmina Children\u2019s Hospital, The Netherlands.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>57 FGR (birth weight &lt;10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th\u201380th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx&gt;0.5) was also calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value &gt;0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2017-313712","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T12:51:36Z","timestamp":1540385496000},"page":"F467-F472","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Cerebrovascular autoregulation in preterm fetal growth restricted neonates"],"prefix":"10.1136","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-5840","authenticated-orcid":false,"given":"Emily","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Neonatology, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht, Utrecht, The Netherlands"},{"name":"The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Baerts","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Caicedo Dorado","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Computer Science, Faculty of Natural Sciences and Mathematics, Universidad del Rosario, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Naulaers","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van Bel","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra M A","family":"Lemmers","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Wilhelmina Children\u2019s Hospital\/University Medical Centre Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"2025090504012898000_104.5.F467.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.03.005"},{"key":"2025090504012898000_104.5.F467.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1487"},{"key":"2025090504012898000_104.5.F467.3","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12696"},{"key":"2025090504012898000_104.5.F467.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.625"},{"key":"2025090504012898000_104.5.F467.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2004"},{"key":"2025090504012898000_104.5.F467.6","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/jp.2014.122","article-title":"The ontogeny of cerebrovascular pressure autoregulation in premature infants","volume":"34","author":"Rhee","year":"2014","journal-title":"J Perinatol"},{"key":"2025090504012898000_104.5.F467.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.06.006"},{"key":"2025090504012898000_104.5.F467.8","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308843"},{"key":"2025090504012898000_104.5.F467.9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7756-4_30"},{"key":"2025090504012898000_104.5.F467.10","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600637861"},{"key":"2025090504012898000_104.5.F467.11","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.186"},{"key":"2025090504012898000_104.5.F467.12","doi-asserted-by":"publisher","DOI":"10.1159\/000063609"},{"key":"2025090504012898000_104.5.F467.13","unstructured":"Fenton TR . 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