{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:16:45Z","timestamp":1791346605182,"version":"4.3.1"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,11,17]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Antenatal corticosteroid (ANC) use before 25 weeks\u2019 gestation is controversial. Our previous systematic review (eight observational studies, n=10\u2009109) showed that ANC exposure was associated with significantly reduced mortality and severe intraventricular haemorrhage (IVH)\/periventricular leukomalacia (PVL) in neonates born &lt;25 weeks. We update our review by adding data (n=3334) from a recent study. We used Cochrane methodology and summarised the results using GRADE (The Grading of Recommendations Assessment, Development and Evaluation) guidelines. Nine high-quality observational studies were included. Meta-analysis (random effects model) showed reduced mortality (n=13\u2009443; OR=0.48 (95% CI 0.42 to 0.55)\u2009P&lt;0.00001; level of evidence (LOE): moderate) and IVH or PVL (n=8418; OR=0.70 (95% CI 0.63 to 0.79), P&lt;0.00001; LOE: moderate) in neonates born &lt;25 weeks exposed to ANC. There was no difference in necrotising enterocolitis (NEC) \u2265stage\u2009II (n=8737; OR=1.01 (95% CI 0.84 to 1.22), P=0.89; LOE: low); incidence of chronic lung disease (CLD) was higher (n=7983; OR=1.32 (95% CI 1.04 to 1.67), P=0.02; LOE: low) in ANC group. Composite outcomes of death\/major morbidities (eg, severe IVH, NEC, CLD) were improved after ANC exposure.<\/jats:p>","DOI":"10.1136\/archdischild-2017-313840","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T12:20:18Z","timestamp":1512476418000},"page":"F173-F176","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Antenatal corticosteroids in impending preterm deliveries before 25 weeks\u2019 gestation"],"prefix":"10.1136","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-4776","authenticated-orcid":false,"given":"Mangesh","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Department of Neonatal Paediatrics, Fiona Stanley Hospital, Perth, Western Australia, Australia"},{"name":"Department of Neonatal Paediatrics, St John of God Subiaco Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patole","sequence":"additional","affiliation":[{"name":"Department of Neonatal Pediatrics, King Edward Memorial Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"2025090512473380000_103.2.F173.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0513"},{"key":"2025090512473380000_103.2.F173.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176090","article-title":"Antenatal corticosteroids for neonates born before 25 Weeks-a systematic review and meta-analysis","volume":"12","author":"Deshmukh","year":"2017","journal-title":"PLoS One"},{"key":"2025090512473380000_103.2.F173.3","first-page":"185","article-title":"Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study","volume":"356","author":"Travers","year":"2017","journal-title":"BMJ"},{"key":"2025090512473380000_103.2.F173.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1607"},{"key":"2025090512473380000_103.2.F173.5","doi-asserted-by":"crossref","first-page":"w13212","DOI":"10.4414\/smw.2011.13212","article-title":"Population based age stratified morbidities of premature infants in Switzerland","volume":"141","author":"Bajwa","year":"2011","journal-title":"Swiss Med Wkly"},{"key":"2025090512473380000_103.2.F173.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1752"},{"key":"2025090512473380000_103.2.F173.7","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1031740"},{"key":"2025090512473380000_103.2.F173.8","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318169ce2d"},{"key":"2025090512473380000_103.2.F173.9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.170340"},{"key":"2025090512473380000_103.2.F173.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.039"},{"key":"2025090512473380000_103.2.F173.11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210892"},{"key":"2025090512473380000_103.2.F173.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.01.012"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2017-313840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:47:43Z","timestamp":1757101663000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2017-313840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,5]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,19]]},"published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1136\/archdischild-2017-313840"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2017-313840","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,5]]}}}