{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:12:41Z","timestamp":1787886761958,"version":"build-2784847793"},"reference-count":23,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated platelet counts are observed in cancer, autoimmunity and inflammation with concurrent illness. Proinflammatory cytokines are elevated in murine osteogenesis imperfecta (OI) models. We hypothesised that platelet counts might be elevated in children with moderate-severe OI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the hospital records of 71 children with moderate-severe OI, treated in the Sheffield Children\u2019s Hospital\u2019s Severe, Complex and Atypical Osteogenesis Imperfecta Highly Specialised Service. Data relating platelet count (below\/above average, above upper limit) to prior and concurrent events were summarised as event proportions per child. Additionally, we created platelet SD scores to assess age and time-related trends, and relationship with OI type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1206 platelet counts were recorded. Platelet SD scores were right-shifted by 0.89 SD overall. 49 of 71 (69%) patients had at least one platelet count above the normal range and 246 (20.4%) of all counts were above the upper limit of normal. Of these, 101 (41%) were high despite no confounding factors being present. For the 47 children with data at age less than 2 years, 89 (30.0%) platelet counts were above the upper limit of normal and 39 (44%) had no associated confounding factor. Elevated platelet counts were recorded most often for children with new or existing vertebral fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Raised platelet counts were observed in association with new and healing vertebral fractures, but also (41%\u201344%) in the absence of identified proinflammatory factors or events. We speculate that these findings are evidence for a proinflammatory component to OI that could be a target for therapeutic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2017-313859","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T16:20:30Z","timestamp":1520958030000},"page":"767-771","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Elevated platelet counts in a cohort of children with moderate-severe osteogenesis imperfecta suggest that inflammation is present"],"prefix":"10.1136","volume":"103","author":[{"given":"Lois","family":"Salter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaka C","family":"Offiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-8546","authenticated-orcid":false,"given":"Nicholas","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"2020050712445623000_103.8.767.1","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1002\/jbmr.2895","article-title":"Mortality and causes of death in patients with osteogenesis imperfecta: a register-based nationwide cohort study","volume":"31","author":"Folkestad","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2020050712445623000_103.8.767.2","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s00198-016-3501-2","article-title":"Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-\u03b1","volume":"27","author":"Brunetti","year":"2016","journal-title":"Osteoporos Int"},{"key":"2020050712445623000_103.8.767.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16051-0"},{"key":"2020050712445623000_103.8.767.4"},{"key":"2020050712445623000_103.8.767.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00947058"},{"key":"2020050712445623000_103.8.767.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.7695699"},{"key":"2020050712445623000_103.8.767.7","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.2.264"},{"key":"2020050712445623000_103.8.767.8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215952"},{"key":"2020050712445623000_103.8.767.9","doi-asserted-by":"publisher","DOI":"10.1186\/cc12716"},{"key":"2020050712445623000_103.8.767.10","doi-asserted-by":"crossref","unstructured":"Gu L , Li H , Gao Y , et al . The association of platelet count with clinicopathological significance and prognosis in renal cell carcinoma: a systematic review and meta-analysis. PLoS One 2015;10:e0125538.doi:10.1371\/journal.pone.0125538","DOI":"10.1371\/journal.pone.0125538"},{"key":"2020050712445623000_103.8.767.11","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPCM1CKASVBMBP"},{"key":"2020050712445623000_103.8.767.12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5604\/17322693.1199305","article-title":"Markers of inflammation, activation of blood platelets and coagulation disorders in inflammatory bowel diseases","volume":"70","author":"Matowicka-Karna","year":"2016","journal-title":"Postepy Hig Med Dosw"},{"key":"2020050712445623000_103.8.767.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh649"},{"key":"2020050712445623000_103.8.767.14","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3544"},{"key":"2020050712445623000_103.8.767.15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219748110"},{"key":"2020050712445623000_103.8.767.16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15109"},{"key":"2020050712445623000_103.8.767.17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92795-2"},{"key":"2020050712445623000_103.8.767.18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2017.06.004","article-title":"Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine","volume":"103","author":"Matthews","year":"2017","journal-title":"Bone"},{"key":"2020050712445623000_103.8.767.19","first-page":"171","article-title":"Physical activity in youth with osteogenesis imperfecta type I","volume":"15","author":"Pouliot-Laforte","year":"2015","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2020050712445623000_103.8.767.20","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1007\/s00198-016-3723-3","article-title":"Osteogenesis imperfecta in children and adolescents-new developments in diagnosis and treatment","volume":"27","author":"Trejo","year":"2016","journal-title":"Osteoporos Int"},{"key":"2020050712445623000_103.8.767.21","first-page":"CD005088","article-title":"Bisphosphonate therapy for osteogenesis imperfecta","volume":"10","author":"Dwan","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2020050712445623000_103.8.767.22","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jbmr.2410","article-title":"Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials","volume":"30","author":"Hald","year":"2015","journal-title":"J Bone Miner Res"},{"key":"2020050712445623000_103.8.767.23","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jbmr.2805","article-title":"Recurrent proximal femur fractures in a teenager with osteogenesis imperfecta on continuous bisphosphonate therapy: are we overtreating?","volume":"31","author":"Vasanwala","year":"2016","journal-title":"J Bone Miner Res"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2017-313859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T22:10:31Z","timestamp":1601071831000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2017-313859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,13]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,7,19]]},"published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1136\/archdischild-2017-313859"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2017-313859","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"value":"0003-9888","type":"print"},{"value":"1468-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,13]]}}}