{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:30:04Z","timestamp":1794580204451,"version":"4.9.1"},"reference-count":51,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2017,12,22]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background and objectives<\/jats:title>\n                  <jats:p>Delivery of inadvertent high tidal volume (V<jats:sub>T<\/jats:sub>) during positive pressure ventilation (PPV) in the delivery room is common. High V<jats:sub>T<\/jats:sub> delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if V<jats:sub>T<\/jats:sub> delivery during PPV at birth is associated with brain injury in preterm infants\u2009&lt;29 weeks\u2019 gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A flow-sensor was placed between the mask and the ventilation device. V<jats:sub>T<\/jats:sub> values were compared with recently described reference ranges for V<jats:sub>T<\/jats:sub> in spontaneously breathing preterm infants at birth. Infants were divided into two groups: V<jats:sub>T<\/jats:sub>&lt;6 \u2009mL\/kg or V<jats:sub>T<\/jats:sub>&gt;6\u2009mL\/kg (normal and high V<jats:sub>T<\/jats:sub>, respectively). Brain injury (eg, intraventricular haemorrhage (IVH)) was assessed using routine ultrasound imaging within the first days after birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 165 preterm infants were included, 124 (75%) had high V<jats:sub>T<\/jats:sub> and 41 (25%) normal V<jats:sub>T<\/jats:sub>. The mean (SD) gestational age and birth weight in high and normal V<jats:sub>T<\/jats:sub> group was similar, 26 (2) and 26 (1) weeks, 858 (251) g and 915 (250) g, respectively. IVH in the high V<jats:sub>T<\/jats:sub> group was diagnosed in 63 (51%) infants compared with 5 (13%) infants in the normal V<jats:sub>T<\/jats:sub> group (P=0.008).<\/jats:p>\n                  <jats:p>Severe IVH (grade III or IV) developed in 33\/124 (27%) infants in the high V<jats:sub>T<\/jats:sub> group and 2\/41 (6%) in the normal V<jats:sub>T<\/jats:sub> group (P=0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High V<jats:sub>T<\/jats:sub> delivery during mask PPV at birth was associated with brain injury. Strategies to limit V<jats:sub>T<\/jats:sub> delivery during mask PPV should be used to prevent high V<jats:sub>T<\/jats:sub> delivery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2017-313864","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T12:20:32Z","timestamp":1516450832000},"page":"F57-F62","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":80,"title":["Impact of delivered tidal volume on the occurrence of intraventricular haemorrhage in preterm infants during positive pressure ventilation in the delivery room"],"prefix":"10.1136","volume":"104","author":[{"given":"Qaasim","family":"Mian","sequence":"first","affiliation":[{"name":"Centre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada"},{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, 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