{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:18:13Z","timestamp":1767651493649},"reference-count":5,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"accepted":{"date-parts":[[2018,7,2]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate a cohort of children with symptomatic joint hypermobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case notes for 318 children with joint hypermobility attending a rheumatology clinic were reviewed for clinical presentation, medical history, psychosocial factors and physical examination findings. Seven key variables were extracted and used as indicator variables in a latent class analysis to estimate the presence and number of subgroups of children with symptomatic joint hypermobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two subgroups with differing clinical presentations were identified accounting for age and gender: an \u2018athletic-persistent\u2019 class (62%) characterised by higher probabilities for recurrent and chronic musculoskeletal pain, and less severe hypermobility; and a \u2018systemic-profound\u2019 class (38%) characterised by generalised hypermobility, recurrent musculoskeletal pain, gastro-oesophageal reflux and motor delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings suggest the presence of two distinct presentations of children with hypermobility. This finding may be important for clinical decision-making and management of this group of children.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2017-314149","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T16:14:44Z","timestamp":1534522484000},"page":"1099-1101","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Two subtypes of symptomatic joint hypermobility: a descriptive study using latent class analysis"],"prefix":"10.1136","volume":"104","author":[{"given":"Francesco","family":"Di Mattia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Fary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Howie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"2024091723401061000_104.11.1099.1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306556"},{"key":"2024091723401061000_104.11.1099.2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ajmg.c.31540","article-title":"Measurement properties of clinical assessment methods for classifying generalized joint hypermobility-A systematic review","volume":"175","author":"Juul-Kristensen","year":"2017","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2024091723401061000_104.11.1099.3","unstructured":"Collins LM , Lanza ST . Latent class and latent transition analysis: with applications in the social, behavioral, and health sciences: John Wiley & Sons, 2013."},{"key":"2024091723401061000_104.11.1099.4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ajmg.c.31424","article-title":"Neurodevelopmental attributes of joint hypermobility syndrome\/Ehlers-Danlos syndrome, hypermobility type: Update and perspectives","volume":"169","author":"Ghibellini","year":"2015","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2024091723401061000_104.11.1099.5","doi-asserted-by":"crossref","unstructured":"Pacey V , Adams RD , Tofts L , et al . Joint hypermobility syndrome subclassification in paediatrics: a factor analytic approach. Arch Dis Child 2015;100.doi:10.1136\/archdischild-2013-305304","DOI":"10.1136\/archdischild-2013-305304"}],"container-title":["Archives of Disease in Childhood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2017-314149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T06:40:32Z","timestamp":1726641632000},"score":1,"resource":{"primary":{"URL":"https:\/\/adc.bmj.com\/lookup\/doi\/10.1136\/archdischild-2017-314149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,17]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,10,18]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/archdischild-2017-314149"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2017-314149","relation":{},"ISSN":["0003-9888","1468-2044"],"issn-type":[{"type":"print","value":"0003-9888"},{"type":"electronic","value":"1468-2044"}],"subject":[],"published":{"date-parts":[[2018,8,17]]}}}