{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:02:18Z","timestamp":1788930138500,"version":"build-2803163510"},"reference-count":33,"publisher":"BMJ","issue":"10","funder":[{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013999","name":"Garfield Weston Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013999","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Children with Down syndrome are at high risk of obstructive sleep apnoea (OSA) and screening is recommended. Diagnosis of OSA should be confirmed with multichannel sleep studies. We aimed to determine whether home pulse oximetry (HPO) discriminates children at high risk of OSA, who need further diagnostic multichannel sleep studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross-sectional prospective study in a training sample recruited through three UK centres. Validation sample used single-centre retrospective analysis of clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Children with Down syndrome aged 0.5\u20136 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Diagnostic multichannel sleep study and HPO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Sensitivity and specificity of HPO to predict moderate-to-severe OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>161\/202 children with Down syndrome met quality criteria for inclusion and 25 had OSA. In this training sample, the best HPO parameter predictors of OSA were the delta 12\u2009s index &gt;0.555 (sensitivity 92%, specificity 65%) and 3% oxyhaemoglobin (SpO<jats:sub>2<\/jats:sub>) desaturation index (3% ODI)&gt;6.15\u2009dips\/hour (sensitivity 92%, specificity 63%). Combining variables (delta 12\u2009s index, 3% ODI, mean and minimum SpO<jats:sub>2<\/jats:sub>) achieved sensitivity of 96% but reduced specificity to 52%. All predictors retained or improved sensitivity in a clinical validation sample of 50 children with variable loss of specificity, best overall was the delta 12\u2009s index, a measure of baseline SpO<jats:sub>2<\/jats:sub>variability (sensitivity 92%; specificity 63%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HPO screening could halve the number of children with Down syndrome needing multichannel sleep studies and reduce the burden on children, families and health services alike. This approach offers a practical universal screening approach for OSA in Down syndrome that is accessible to the non-specialist paediatrician.<\/jats:p><\/jats:sec>","DOI":"10.1136\/archdischild-2017-314409","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T16:20:33Z","timestamp":1526314833000},"page":"962-967","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Home oximetry to screen for obstructive sleep apnoea in Down syndrome"],"prefix":"10.1136","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-5904","authenticated-orcid":false,"given":"Catherine M","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"Elphick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Farquhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gringras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth N","family":"Kingshott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C","family":"Gavlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel J","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"2020050712425433000_103.10.962.1","doi-asserted-by":"crossref","unstructured":"Marcus CL , Keens TG , Bautista DB , et al . 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