{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:58:54Z","timestamp":1776459534812,"version":"3.51.2"},"reference-count":5,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2018,9,30]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Babies may use alternative cerebral fuels including ketones when blood glucose concentrations are low, but laboratory ketone measurements are slow and expensive. Point-of-care measurement of ketone concentrations, if sufficiently accurate, may provide useful information for clinical care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and design<\/jats:title>\n                  <jats:p>Eligible babies were 35\u201342 weeks\u2019 gestation, \u226410 days old and admitted to the newborn intensive care unit. At the time of clinically indicated blood tests, additional samples were taken to measure beta-hydroxybutyrate using a point-of-care analyser and the laboratory method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One-hundred and fifty babies had 142 paired samples. Overall point-of-care accuracy was excellent (mean difference 0.00\u2009mmol\/L) and precision was moderate (SD 0.18\u2009mmol\/L). A point-of-care measurement \u22650.4\u2009mmol\/L was highly predictive of a laboratory measurement \u22650.4\u2009mmol\/L (area under the curve 0.98).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Point-of-care measurement of blood beta-hydroxybutyrate concentrations is sufficiently accurate in newborns to be potentially useful in clinical care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>Registered with the Australian and New Zealand Clinical Trials Registry ACTRN: 12616000784415. The study was registered before recruitment commenced.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2018-316293","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:41:26Z","timestamp":1541392886000},"page":"F544-F546","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Point-of-care measurements of blood ketones in newborns"],"prefix":"10.1136","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-9223","authenticated-orcid":false,"given":"Deborah L","family":"Harris","sequence":"first","affiliation":[{"name":"Newborn Intensive Care Unit, Waikato District Health Board, Hamilton, New Zealand"},{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J","family":"Weston","sequence":"additional","affiliation":[{"name":"Newborn Intensive Care Unit, Waikato District Health Board, Hamilton, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E","family":"Harding","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2025090509533858000_104.5.F544.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1972.tb16098.x"},{"key":"2025090509533858000_104.5.F544.2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301781"},{"key":"2025090509533858000_104.5.F544.3","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12193"},{"key":"2025090509533858000_104.5.F544.4","first-page":"133","article-title":"Ketone body elevation in placenta, umbilical cord, newborn and mother in normal delivery","volume":"3","author":"Muneta","year":"2016","journal-title":"Glycative Stress Res"},{"key":"2025090509533858000_104.5.F544.5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/POC.0000000000000153","article-title":"Feasibility of the use of point-of-care technology to measure ketone and lactate levels in the newborn at risk for hypoglycemia","volume":"17","author":"Crawford","year":"2018","journal-title":"Point of Care"}],"container-title":["Archives of Disease in Childhood - Fetal and Neonatal Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/archdischild-2018-316293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T16:53:50Z","timestamp":1757091230000},"score":1,"resource":{"primary":{"URL":"https:\/\/fn.bmj.com\/lookup\/doi\/10.1136\/archdischild-2018-316293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,8,19]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/archdischild-2018-316293"],"URL":"https:\/\/doi.org\/10.1136\/archdischild-2018-316293","relation":{},"ISSN":["1359-2998","1468-2052"],"issn-type":[{"value":"1359-2998","type":"print"},{"value":"1468-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}