{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:40:33Z","timestamp":1764873633823,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Arch Dis Child Fetal Neonatal Ed"],"accepted":{"date-parts":[[2019,3,22]]},"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether different chest compression (CC) rates during continuous CC with asynchronous ventilations (CCaV) reduce time to return of spontaneous circulation (ROSC) and improved haemodynamic recovery in piglets aged 24\u201372\u2009hours with asphyxia-induced asystole.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty piglets (aged 24\u201372\u2009hours) were anaesthetised, intubated, instrumented and exposed to 30\u2009min normocapnic hypoxia followed by asphyxia. Piglets were randomised into four groups: CCaV with CC rate of 90 (CCaV+90, n=8), 100 (CCaV+100, n=8) or 120 compressions per minute (CCaV+120, n=8), and a sham-operated group (n=6). Cardiac function, carotid blood flow, cerebral and renal oxygenation and respiratory parameters were continuously recorded. Cerebral cortical tissue was harvested and assayed for inflammatory and injury markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All three intervention groups had a similar number of piglets achieving ROSC (6\/8, 5\/8 and 5\/8 for CCaV+120, CCaV+100 and CCaV+90, respectively) and mean ROSC time (120, 90 and 90\u2009s for CCaV+120, CCaV+100 and CCaV+90, respectively). The haemodynamic recovery (indicated by carotid flow, cerebral and renal perfusion) was similar between CCaV+120\u2009and sham by the end of experiment. In comparison, CCaV+90\u2009and CCaV+100\u2009had significantly reduced haemodynamic recovery compared with sham operated (p\u22640.05). Inflammatory (interleukin [IL]-6 and IL-1\u03b2) and injury markers (lactate) were significantly higher in the frontoparietal cortex of CCaV+90\u2009and CCaV+100\u2009compared with sham, whereas brain injury markers were similar between CCaV+120\u2009and sham.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although there was no difference between the groups in achieving ROSC, the haemodynamic recovery of CCaV+120\u2009was significantly improved compared with CCaV+90\u2009and CCaV+100, which were also associated with higher cerebral inflammatory and brain injury markers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/archdischild-2018-316610","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T17:24:21Z","timestamp":1558632261000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Asynchronous ventilation at 120 compared with 90 or 100 compressions per minute improves haemodynamic recovery in asphyxiated newborn piglets"],"prefix":"10.1136","volume":"105","author":[{"given":"Sparsh","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[{"name":"Neonatal Research Unit, Centre of the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo P","family":"Pasquin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[{"name":"Neonatal Research Unit, Centre of the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-2415","authenticated-orcid":false,"given":"Georg M","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Neonatology, Royal Alexandra Hospital, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"2025090510193368000_105.4.357.1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/apa.13116","article-title":"Neonatal resuscitation beyond the delivery room - 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