{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:48:53Z","timestamp":1788385733632,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"KELIN New Talent Project of The First Affiliated Hospital, Sun Yat-sen University","award":["Y12001"],"award-info":[{"award-number":["Y12001"]}]},{"name":"Special Support Plan for High-Level Talent of Guangdong Province, China","award":["2016TQ03R667"],"award-info":[{"award-number":["2016TQ03R667"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772307"],"award-info":[{"award-number":["81772307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972039"],"award-info":[{"award-number":["81972039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2017A050501016"],"award-info":[{"award-number":["2017A050501016"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2021B1515020080"],"award-info":[{"award-number":["2021B1515020080"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1136\/ard-2022-223428","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T13:20:20Z","timestamp":1671628820000},"page":"533-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis"],"prefix":"10.1016","volume":"82","author":[{"given":"Siwen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-1290","authenticated-orcid":false,"given":"Zhaomin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-402X","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard-2022-223428_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0140-6736(16)31591-4","article-title":"Axial spondyloarthritis","volume":"390","author":"Sieper","year":"2017","journal-title":"Lancet"},{"key":"10.1136\/ard-2022-223428_bib2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/acr.24025","article-title":"2019 update of the American College of Rheumatology\/Spondylitis association of America\/Spondyloarthritis research and treatment network recommendations for the treatment of ankylosing spondylitis and Nonradiographic axial spondyloarthritis","volume":"71","author":"Ward","year":"2019","journal-title":"Arthritis Care Res"},{"key":"10.1136\/ard-2022-223428_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nrrheum.2016.42","article-title":"New evidence on the management of spondyloarthritis","volume":"12","author":"Sieper","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib4","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrrheum.2011.156","article-title":"The balance of tissue repair and remodeling in chronic arthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/BOR.0000000000000179","article-title":"Syndesmophyte growth in ankylosing spondylitis","volume":"27","author":"Tan","year":"2015","journal-title":"Curr Opin Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib6","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3389\/fimmu.2018.02668","article-title":"The early phases of ankylosing spondylitis: emerging insights from clinical and basic science","volume":"9","author":"Watad","year":"2018","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2022-223428_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/annrheumdis-2013-203643","article-title":"Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells","volume":"73","author":"Jacques","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib8","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1002\/art.23078","article-title":"Histopathologic changes at \u201csynovio\u2013entheseal complexes\u201d suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis","volume":"56","author":"Benjamin","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2022-223428_bib9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.berh.2014.10.009","article-title":"The role of mechanical stress in the pathogenesis of spondyloarthritis and how to combat it","volume":"28","author":"Jacques","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib10","first-page":"2155","article-title":"An enthesitis based model for the pathogenesis of spondyloarthropathy. Additive effects of microbial adjuvant and biomechanical factors at disease sites","volume":"28","author":"McGonagle","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib11","first-page":"3","article-title":"A 2003 update of bone physiology and Wolff's law for clinicians","volume":"74","author":"Frost","year":"2004","journal-title":"Angle Orthod"},{"key":"10.1136\/ard-2022-223428_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav7756","article-title":"Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration","volume":"11","author":"McDermott","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1136\/ard-2022-223428_bib13","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1242\/dev.151266","article-title":"Mechanical regulation of musculoskeletal system development","volume":"144","author":"Felsenthal","year":"2017","journal-title":"Development"},{"key":"10.1136\/ard-2022-223428_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature25453","article-title":"Structure of the mechanically activated ion channel Piezo1","volume":"554","author":"Saotome","year":"2018","journal-title":"Nature"},{"key":"10.1136\/ard-2022-223428_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41413-021-00168-8","article-title":"Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues","volume":"9","author":"Qin","year":"2021","journal-title":"Bone Res"},{"key":"10.1136\/ard-2022-223428_bib16","doi-asserted-by":"crossref","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1136\/ard-2022-223428_bib17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jbmr.4198","article-title":"Piezo 1 inactivation in chondrocytes impairs trabecular bone formation","volume":"36","author":"Hendrickx","year":"2021","journal-title":"J Bone Miner Res"},{"key":"10.1136\/ard-2022-223428_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52779","article-title":"Piezo1\/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-\u00df-catenin","volume":"9","author":"Zhou","year":"2020","journal-title":"eLife"},{"key":"10.1136\/ard-2022-223428_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47454","article-title":"The mechanosensitive Piezo1 channel is required for bone formation","volume":"8","author":"Sun","year":"2019","journal-title":"Elife"},{"key":"10.1136\/ard-2022-223428_bib20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein Piezo1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/art.39298","article-title":"American College of Rheumatology\/Spondylitis association of America\/Spondyloarthritis research and treatment network 2015 recommendations for the treatment of ankylosing spondylitis and Nonradiographic axial spondyloarthritis","volume":"68","author":"Ward","year":"2016","journal-title":"Arthritis & Rheumatology"},{"key":"10.1136\/ard-2022-223428_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00586-017-5421-z","article-title":"Osteotomies in ankylosing spondylitis: where, how many, and how much?","volume":"27","author":"Koller","year":"2018","journal-title":"Eur Spine J"},{"key":"10.1136\/ard-2022-223428_bib23","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.3171\/FOC\/2008\/24\/1\/E10","article-title":"Perioperative challenges in the surgical management of ankylosing spondylitis","volume":"24","author":"Sciubba","year":"2008","journal-title":"Neurosurg Focus"},{"key":"10.1136\/ard-2022-223428_bib24","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2106\/00004623-200108000-00006","article-title":"Adolescent idiopathic scoliosis: a new classification to determine extent of spinal arthrodesis","volume":"83","author":"Lenke","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1136\/ard-2022-223428_bib25","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.spinee.2012.11.059","article-title":"An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis (update)","volume":"13","author":"Kreiner","year":"2013","journal-title":"Spine J"},{"key":"10.1136\/ard-2022-223428_bib26","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/art.39282","article-title":"Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis","volume":"67","author":"Vieira-Sousa","year":"2015","journal-title":"Arthritis & Rheumatology"},{"key":"10.1136\/ard-2022-223428_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by Piezo1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"10.1136\/ard-2022-223428_bib28","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1084\/jem.20180483","article-title":"Piezo1 and Gq\/G11 promote endothelial inflammation depending on flow pattern and integrin activation","volume":"215","author":"Albarr\u00e1n-Ju\u00e1rez","year":"2018","journal-title":"J Exp Med"},{"key":"10.1136\/ard-2022-223428_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg5859","article-title":"Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 + T cell responses","volume":"7","author":"Jairaman","year":"2021","journal-title":"Sci. Adv"},{"key":"10.1136\/ard-2022-223428_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49631","article-title":"Stimulation of Piezo1 by mechanical signals promotes bone anabolism","volume":"8","author":"Li","year":"2019","journal-title":"eLife"},{"key":"10.1136\/ard-2022-223428_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","article-title":"Bone development","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone"},{"key":"10.1136\/ard-2022-223428_bib32","article-title":"Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1\/FGFR1 signaling pathway in mice","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib33","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41467-018-04405-3","article-title":"Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1","volume":"9","author":"Lacroix","year":"2018","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib34","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41467-019-09653-5","article-title":"TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling","volume":"10","author":"Li","year":"2019","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1136\/annrheumdis-2011-200216","article-title":"High level of functional Dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis","volume":"71","author":"Heiland","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib36","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40468","article-title":"Inflammation intensity-dependent expression of osteoinductive Wnt proteins is critical for ectopic new bone formation in ankylosing spondylitis","volume":"70","author":"Li","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41584-018-0091-8","article-title":"Effects of the IL-23\u2013IL-17 pathway on\u00a0bone in spondyloarthritis","volume":"14","author":"Gravallese","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib38","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1136\/annrheumdis-2019-215356","article-title":"The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies","volume":"78","author":"McGonagle","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib39","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nm.2817","article-title":"IL-23 induces spondyloarthropathy by acting on ROR-\u03b3t+ CD3+CD4\u2212CD8\u2212 entheseal resident T cells","volume":"18","author":"Sherlock","year":"2012","journal-title":"Nat Med"},{"key":"10.1136\/ard-2022-223428_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrrheum.2017.56","article-title":"Pathogenesis of ankylosing spondylitis \u2014 recent advances and future directions","volume":"13","author":"Ranganathan","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib41","first-page":"488","article-title":"Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies","volume":"56","author":"El-Zayadi","year":"2017","journal-title":"Rheumatology"},{"key":"10.1136\/ard-2022-223428_bib42","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1123\/ijsnem.11.s1.s128","article-title":"Cellular and molecular mechanisms for the bone response to mechanical loading","volume":"11","author":"Bloomfield","year":"2001","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1136\/ard-2022-223428_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11154-015-9313-4","article-title":"Physiological mechanisms and therapeutic potential of bone mechanosensing","volume":"16","author":"Xiao","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1136\/ard-2022-223428_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11914-019-00520-2","article-title":"Integrins in osteocyte biology and mechanotransduction","volume":"17","author":"Geoghegan","year":"2019","journal-title":"Curr Osteoporos Rep"},{"key":"10.1136\/ard-2022-223428_bib45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of\u00a0the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1136\/ard-2022-223428_bib46","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1096\/fj.13-245936","article-title":"Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations","volume":"28","author":"Leddy","year":"2014","journal-title":"FASEB J"},{"key":"10.1136\/ard-2022-223428_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06690-4","article-title":"TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw","volume":"9","author":"Gomes","year":"2018","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib48","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1002\/jcp.27432","article-title":"Knockdown of TRPV4 suppresses osteoclast differentiation and osteoporosis by inhibiting autophagy through Ca 2+ \u2013calcineurin\u2013NFATc1 pathway","volume":"234","author":"Cao","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1136\/ard-2022-223428_bib49","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3899\/jrheum.090986","article-title":"Immunohistochemical analysis of osteoblasts in zygapophyseal joints of patients with ankylosing spondylitis reveal repair mechanisms similar to osteoarthritis","volume":"37","author":"Appel","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrrheum.2017.188","article-title":"Enthesitis: from pathophysiology to treatment","volume":"13","author":"Schett","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib51","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neuron.2018.09.046","article-title":"A feedforward mechanism mediated by mechanosensitive ion channel Piezo1 and tissue mechanics promotes glioma aggression","volume":"100","author":"Chen","year":"2018","journal-title":"Neuron"},{"key":"10.1136\/ard-2022-223428_bib52","first-page":"5981","article-title":"CaMKII plays a part in the chondrogenesis of bone marrow-derived mesenchymal stem cells","volume":"8","author":"Qu","year":"2015","journal-title":"Int J Clin Exp Patho"},{"key":"10.1136\/ard-2022-223428_bib53","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/art.22372","article-title":"Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis","volume":"56","author":"Lories","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2022-223428_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11926-019-0856-3","article-title":"The pathogenesis of ankylosing spondylitis: an update","volume":"21","author":"Pedersen","year":"2019","journal-title":"Curr Rheumatol Rep"},{"key":"10.1136\/ard-2022-223428_bib55","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/art.40770","article-title":"Interleukin-17A inhibition diminishes inflammation and new bone formation in experimental spondyloarthritis","volume":"71","author":"van Tok","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib56","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200288","article-title":"Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis","volume":"217","author":"Kaaij","year":"2020","journal-title":"J Exp Med"},{"key":"10.1136\/ard-2022-223428_bib57","doi-asserted-by":"crossref","first-page":"104519","DOI":"10.1016\/j.archoralbio.2019.104519","article-title":"Coronarin D affects TNF-\u03b1 induced proliferation and osteogenic differentiation of human periodontal ligament stem cells","volume":"108","author":"Jiang","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1136\/ard-2022-223428_bib58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41584-019-0364-x","article-title":"Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis","volume":"16","author":"Gracey","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib59","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41590-020-0741-2","article-title":"The mesenchymal context in inflammation, immunity and cancer","volume":"21","author":"Koliaraki","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1136\/ard-2022-223428_bib60","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/annrheumdis-2021-220002","article-title":"Tenascin-C-mediated suppression of extracellular matrix adhesion force promotes entheseal new bone formation through activation of Hippo signalling in ankylosing spondylitis","volume":"80","author":"Li","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2001611118","article-title":"Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis","volume":"118","author":"Lee","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1136\/ard-2022-223428_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by Piezo1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"10.1136\/ard-2022-223428_bib63","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1084\/jem.20180483","article-title":"Piezo1 and Gq\/G11 promote endothelial inflammation depending on flow pattern and integrin activation","volume":"215","author":"Albarr\u00e1n-Ju\u00e1rez","year":"2018","journal-title":"J Exp Med"},{"key":"10.1136\/ard-2022-223428_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb5168","article-title":"Targeting Piezo1 unleashes innate immunity against cancer and infectious disease","volume":"5","author":"Aykut","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1136\/ard-2022-223428_bib65","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04194-9","article-title":"Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis","volume":"9","author":"Romac","year":"2018","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2022-223428_bib67","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/1756-185X.12305","article-title":"Histopathological changes in supraspinous ligaments, ligamentum flava and paraspinal muscle tissues of patients with ankylosing spondylitis","volume":"19","author":"Zhang","year":"2016","journal-title":"Int J Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib68","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/ard.61.6.534","article-title":"Histological assessment of the early enthesitis lesion in spondyloarthropathy","volume":"61","author":"McGonagle","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2022-223428_bib69","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.berh.2018.07.004","article-title":"The SKG model of spondyloarthritis","volume":"31","author":"Rahman","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/ard-2022-223428_bib70","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/01.bor.0000231900.81677.c5","article-title":"Animal models of spondyloarthritis","volume":"18","author":"Lories","year":"2006","journal-title":"Curr Opin Rheumatol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724004400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724004400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard-2022-223428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T01:05:03Z","timestamp":1737421503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724004400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0003496724004400"],"URL":"https:\/\/doi.org\/10.1136\/ard-2022-223428","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard-2022-223428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 \u00a9 Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}