{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:49:41Z","timestamp":1792457381397,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China grants","doi-asserted-by":"crossref","award":["81900523"],"award-info":[{"award-number":["81900523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China grants","doi-asserted-by":"crossref","award":["82170173"],"award-info":[{"award-number":["82170173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1136\/ard-2023-224363","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:25:54Z","timestamp":1689873954000},"page":"1348-1358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1232-7954","authenticated-orcid":false,"given":"Yanmei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4178-9314","authenticated-orcid":false,"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2416-9951","authenticated-orcid":false,"given":"Zhigang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard-2023-224363_bib1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"IgG4-related disease","volume":"385","author":"Kamisawa","year":"2015","journal-title":"Lancet"},{"key":"10.1136\/ard-2023-224363_bib2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41584-020-0500-7","article-title":"IgG4-related disease: an update on pathophysiology and implications for clinical care","volume":"16","author":"Perugino","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2023-224363_bib3","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1136\/annrheumdis-2012-201477","article-title":"Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related Dacryoadenitis and Sialoadenitis, so-called Mikulicz's disease","volume":"71","author":"Maehara","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224363_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102944","article-title":"The landscape of T and B lymphocytes interaction and synergistic effects of Th1 and Th2 type response in the involved tissue of IgG4-RD revealed by single cell transcriptome analysis","volume":"133","author":"Cai","year":"2022","journal-title":"J Autoimmun"},{"key":"10.1136\/ard-2023-224363_bib5","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1136\/ard-2023-224363_bib6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/annrheumdis-2014-205233","article-title":"Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations","volume":"74","author":"Wallace","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224363_bib7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molcel.2015.04.005","article-title":"The technology and biology of single-cell RNA sequencing","volume":"58","author":"Kolodziejczyk","year":"2015","journal-title":"Mol Cell"},{"key":"10.1136\/ard-2023-224363_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.aan6828","article-title":"Single-cell transcriptomics to explore the immune system in health and disease","volume":"358","author":"Stubbington","year":"2017","journal-title":"Science"},{"key":"10.1136\/ard-2023-224363_bib9","article-title":"Single-cell sequencing of immune cell heterogeneity in IgG4-related disease","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224363_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/annrheumdis-2019-216561","article-title":"The 2019 American college of rheumatology\/European League against rheumatism classification criteria for IgG4-related disease","volume":"79","author":"Wallace","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224363_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/259408","article-title":"Development of an IgG4-RD responder index","volume":"2012","author":"Carruthers","year":"2012","journal-title":"Int J Rheumatol"},{"key":"10.1136\/ard-2023-224363_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12672-022-00516-y","article-title":"Prioritizing risk genes as novel stratification biomarkers for acute Monocytic leukemia by integrative analysis","volume":"13","author":"He","year":"2022","journal-title":"Discov Oncol"},{"key":"10.1136\/ard-2023-224363_bib13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41591-021-01296-8","article-title":"SARS-Cov-2 infection of the oral cavity and saliva","volume":"27","author":"Huang","year":"2021","journal-title":"Nat Med"},{"key":"10.1136\/ard-2023-224363_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"10.1136\/ard-2023-224363_bib15","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T cell subset with stem cell-like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat Med"},{"key":"10.1136\/ard-2023-224363_bib16","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2017.02.007","article-title":"Increases in IGE, Eosinophils, and mast cells can be used in diagnosis and to predict relapse of IgG4-related disease","volume":"15","author":"Culver","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1136\/ard-2023-224363_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10285","article-title":"IL-7 signalling represses Bcl-6 and the TFH gene program","volume":"7","author":"McDonald","year":"2016","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2023-224363_bib18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.immuni.2013.04.009","article-title":"Transcriptional regulation of germinal center B and plasma cell Fates by dynamical control of IRF4","volume":"38","author":"Ochiai","year":"2013","journal-title":"Immunity"},{"key":"10.1136\/ard-2023-224363_bib19","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.1073\/pnas.1205834109","article-title":"Transcription factor Irf4 determines germinal center formation through follicular T-helper cell differentiation","volume":"109","author":"Bollig","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1136\/ard-2023-224363_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.941962","article-title":"Protein ubiquitination in T cell development","volume":"13","author":"Zhong","year":"2022","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224363_bib21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/JLB.1MR0720-185RR","article-title":"The role of ubiquitinase in B cell development and function","volume":"109","author":"Zhang","year":"2021","journal-title":"J Leukoc Biol"},{"key":"10.1136\/ard-2023-224363_bib22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s12016-018-8679-y","article-title":"The immunologic paradoxes of IgG4-related disease","volume":"54","author":"Xiao","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1136\/ard-2023-224363_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102701","article-title":"Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: implications in DNA repair and immune responses","volume":"83","author":"Mandke","year":"2019","journal-title":"DNA Repair (Amst)"},{"key":"10.1136\/ard-2023-224363_bib24","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1091\/mbc.E20-10-0685","article-title":"Actomyosin dynamics modulate microtubule deformation and growth during T-cell activation","volume":"32","author":"Rey-Suarez","year":"2021","journal-title":"Mol Biol Cell"},{"key":"10.1136\/ard-2023-224363_bib25","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.4049\/jimmunol.1202976","article-title":"B cell activation is regulated by the stiffness properties of the substrate presenting the antigens","volume":"190","author":"Wan","year":"2013","journal-title":"J Immunol"},{"key":"10.1136\/ard-2023-224363_bib26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/bj3030681","article-title":"Structure and function of type II DNA topoisomerases","volume":"303","author":"Watt","year":"1994","journal-title":"Biochem J"},{"key":"10.1136\/ard-2023-224363_bib27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ijc.23968","article-title":"TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance","volume":"124","author":"Wong","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1136\/ard-2023-224363_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.668007","article-title":"Comparative analysis on abnormal methylome of differentially expressed genes and disease pathways in the immune cells of RA and SLE","volume":"12","author":"Fang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224363_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0378-1119(99)00305-4","article-title":"Regulation of E2F: a family of transcription factors involved in proliferation control","volume":"237","author":"Black","year":"1999","journal-title":"Gene"},{"key":"10.1136\/ard-2023-224363_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1182\/blood-2009-12-259549","article-title":"Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+Cd11B+ myeloid cells","volume":"117","author":"Mahdipour","year":"2011","journal-title":"Blood"},{"key":"10.1136\/ard-2023-224363_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.exphem.2018.11.008","article-title":"Smc3 is required for mouse embryonic and adult hematopoiesis","volume":"70","author":"Wang","year":"2019","journal-title":"Exp Hematol"},{"key":"10.1136\/ard-2023-224363_bib32","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/art.40524","article-title":"Role of stem cell-like memory T cells in systemic lupus erythematosus","volume":"70","author":"Lee","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224363_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.4049\/jimmunol.1600089","article-title":"Features of human Cd3+Cd20+ T cells","volume":"197","author":"Schuh","year":"2016","journal-title":"J Immunol"},{"key":"10.1136\/ard-2023-224363_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.humimm.2019.01.001","article-title":"Cd3(+)Cd20(+) T cells and their roles in human diseases","volume":"80","author":"Chen","year":"2019","journal-title":"Human Immunology"},{"key":"10.1136\/ard-2023-224363_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/cei.13000","article-title":"cDNA microarray analysis identifies Nr4A2 as a novel molecule involved in the pathogenesis of Sj\u00f6gren's syndrome","volume":"190","author":"Takahashi","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard-2023-224363_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.592490","article-title":"Transcriptome sequencing reveals potential roles of ICOS in primary Sj\u00f6gren's syndrome","volume":"8","author":"Luo","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1136\/ard-2023-224363_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102847","article-title":"Emerging role of galectin family in inflammatory autoimmune diseases","volume":"20","author":"Xu","year":"2021","journal-title":"Autoimmun Rev"},{"key":"10.1136\/ard-2023-224363_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102575","article-title":"Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways","volume":"117","author":"Chakraborty","year":"2021","journal-title":"J Autoimmun"},{"key":"10.1136\/ard-2023-224363_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-020-00354-w","article-title":"NAD(+) metabolism, stemness, the immune response, and cancer","volume":"6","author":"Navas","year":"2021","journal-title":"Sig Transduct Target Ther"},{"key":"10.1136\/ard-2023-224363_bib40","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/ar3810","article-title":"Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance","volume":"14","author":"Kiyama","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224363_bib41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2018.12.005","article-title":"Targeting the Cd40-Cd40L pathway in autoimmune diseases: humoral immunity and beyond","volume":"141","author":"Karnell","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1136\/ard-2023-224363_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01795","article-title":"Multiple processes may involve in the Igg4-RD pathogenesis: an integrative study via proteomic and transcriptomic analysis","volume":"11","author":"Cai","year":"2020","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224363_bib43","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/PAS.0000000000000206","article-title":"Epstein-barr virus-infected cells in IgG4-related Lymphadenopathy with comparison with extranodal IgG4-related disease","volume":"38","author":"Takeuchi","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1136\/ard-2023-224363_bib44","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/lary.25153","article-title":"Epstein-barr virus in the enlarged salivary tissues of patients with IgG4-related disease","volume":"125","author":"Furukawa","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1136\/ard-2023-224363_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07008-0","article-title":"Human antibodies targeting Zika virus Ns1 provide protection against disease in a mouse model","volume":"9","author":"Bailey","year":"2018","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2023-224363_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111528","article-title":"Potent Monoclonal antibodies neutralize Omicron Sublineages and other SARS-Cov-2 variants","volume":"41","author":"Chen","year":"2022","journal-title":"Cell Rep"},{"key":"10.1136\/ard-2023-224363_bib47","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1002\/hep.26232","article-title":"Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis","volume":"57","author":"Maillette de Buy Wenniger","year":"2013","journal-title":"Hepatology"},{"key":"10.1136\/ard-2023-224363_bib48","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13075-019-2069-6","article-title":"High-throughput sequencing of Cd4(+) T cell repertoire reveals disease-specific signatures in IgG4-related disease","volume":"21","author":"Wang","year":"2019","journal-title":"Arthritis Res Ther"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724102956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724102956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard-2023-224363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:04:07Z","timestamp":1737349447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724102956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0003496724102956"],"URL":"https:\/\/doi.org\/10.1136\/ard-2023-224363","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard-2023-224363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 \u00a9 Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}