{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:44:22Z","timestamp":1791643462839,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023392","name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC","award":["G0800648"],"award-info":[{"award-number":["G0800648"]}]},{"name":"MRC\/Arthritis Research UK","award":["MR-K015346"],"award-info":[{"award-number":["MR-K015346"]}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1136\/ard-2023-224540","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T18:20:14Z","timestamp":1700331614000},"page":"288-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome"],"prefix":"10.1016","volume":"83","author":[{"given":"Katriona","family":"Goldmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-6585","authenticated-orcid":false,"given":"Athina","family":"Spiliopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Iakovliev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-9344","authenticated-orcid":false,"given":"Darren","family":"Plant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cankut","family":"Cubuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-1034","authenticated-orcid":false,"given":"Paul","family":"McKeigue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-2527","authenticated-orcid":false,"given":"Anne","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-5051","authenticated-orcid":false,"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-5345","authenticated-orcid":false,"given":"Myles J","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard-2023-224540_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1136\/ard-2023-224540_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/annrheumdis-2018-213678","article-title":"Genetics of rheumatoid arthritis: 2018 status","volume":"78","author":"Okada","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224540_bib3","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1093\/hmg\/ddv077","article-title":"Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases","volume":"24","author":"Guo","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1136\/ard-2023-224540_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1136\/ard-2023-224540_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ng.2205","article-title":"Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles","volume":"44","author":"Fairfax","year":"2012","journal-title":"Nat Genet"},{"key":"10.1136\/ard-2023-224540_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002431","article-title":"Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression","volume":"8","author":"Fu","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1136\/ard-2023-224540_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.40393","article-title":"Cd4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in patients with untreated early arthritis: implications for causal gene identification","volume":"70","author":"Thalayasingam","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224540_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"Battle","year":"2017","journal-title":"Nature"},{"key":"10.1136\/ard-2023-224540_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf3041","article-title":"Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease","volume":"376","author":"Yazar","year":"2022","journal-title":"Science"},{"key":"10.1136\/ard-2023-224540_bib10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/annrheumdis-2018-214877","article-title":"Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for Cd40 and Cd39","volume":"78","author":"Spiliopoulou","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224540_bib11","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1136\/ard-2023-224540_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1136\/ard-2023-224540_bib13","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar2912","article-title":"Regulation of IFN response gene activity during Infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment","volume":"12","author":"van Baarsen","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224540_bib14","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.celrep.2019.07.091","article-title":"Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes","volume":"28","author":"Lewis","year":"2019","journal-title":"Cell Rep"},{"key":"10.1136\/ard-2023-224540_bib15","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/annrheumdis-2022-222370","article-title":"Interferon-\u0391-mediated therapeutic resistance in early rheumatoid arthritis Implicates epigenetic reprogramming","volume":"81","author":"Cooles","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224540_bib16","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.3899\/jrheum.110615","article-title":"Synovial infiltration with Cd79A-positive B cells, but not other B cell lineage markers, correlates with joint destruction in rheumatoid arthritis","volume":"38","author":"Mo","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2023-224540_bib17","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/cei.13024","article-title":"B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets","volume":"190","author":"Becerra","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard-2023-224540_bib18","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.4049\/jimmunol.1202860","article-title":"Human FC receptor-like 5 binds intact IgG via mechanisms distinct from those of FC receptors","volume":"190","author":"Franco","year":"2013","journal-title":"J Immunol"},{"key":"10.1136\/ard-2023-224540_bib19","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1242\/jcs.067777","article-title":"N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms","volume":"123","author":"Di Benedetto","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1136\/ard-2023-224540_bib20","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/jphp.12410","article-title":"Quantitative analysis of cadherin-11 and \u0392-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells","volume":"67","author":"Yoshioka","year":"2015","journal-title":"J Pharm Pharmacol"},{"key":"10.1136\/ard-2023-224540_bib21","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1136\/ard-2023-224540_bib22","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fphar.2020.00757","article-title":"The bone extracellular matrix in bone formation and regeneration","volume":"11","author":"Lin","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1136\/ard-2023-224540_bib23","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1242\/jcs.107.11.3055","article-title":"The effects of selective inhibitors of matrix metalloproteinases (Mmps) on bone resorption and the identification of Mmps and TIMP-1 in isolated osteoclasts","author":"Hill","year":"1994","journal-title":"J Cell Sci"},{"key":"10.1136\/ard-2023-224540_bib24","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/hmg\/ddu013","article-title":"Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice","volume":"23","author":"Muir","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1136\/ard-2023-224540_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","article-title":"Notch signalling drives synovial fibroblast identity and arthritis pathology","volume":"582","author":"Wei","year":"2020","journal-title":"Nature"},{"key":"10.1136\/ard-2023-224540_bib26","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1136\/ard-2023-224540_bib27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S1097-2765(01)00401-4","article-title":"The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor","volume":"8","author":"Huang","year":"2001","journal-title":"Mol Cell"},{"key":"10.1136\/ard-2023-224540_bib28","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1016\/j.cellsig.2014.08.025","article-title":"Coiled-coil domain containing 3 (Ccdc3) represses tumor necrosis factor-\u0391\/nuclear factor \u039aB-induced endothelial inflammation","volume":"26","author":"Azad","year":"2014","journal-title":"Cell Signal"},{"key":"10.1136\/ard-2023-224540_bib29","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","article-title":"Matrix eQTL: ultra fast eQTL analysis via large matrix operations","volume":"28","author":"Shabalin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1136\/ard-2023-224540_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/biostatistics\/kxx048","article-title":"An empirical Bayes approach for multiple tissue eQTL analysis","volume":"19","author":"Li","year":"2018","journal-title":"Biostatistics"},{"key":"10.1136\/ard-2023-224540_bib31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMoa0912923","article-title":"Nt5E mutations and arterial calcifications","volume":"364","author":"St Hilaire","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1136\/ard-2023-224540_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/jhg.2015.85","article-title":"Calcification of joints and arteries: second report with novel Nt5E mutations and expansion of the phenotype","volume":"60","author":"Zhang","year":"2015","journal-title":"J Hum Genet"},{"key":"10.1136\/ard-2023-224540_bib33","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/1358863X17724263","article-title":"Calcification of joints and arteries with novel Nt5E mutations with involvement of upper extremity arteries","volume":"22","author":"Yoshioka","year":"2017","journal-title":"Vasc Med"},{"key":"10.1136\/ard-2023-224540_bib34","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/art.39548","article-title":"Identification of a systemic lupus erythematosus risk locus spanning Atg16L2, Fchsd2, and P2Ry2 in Koreans","volume":"68","author":"Lessard","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224540_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41232-021-00157-8","article-title":"Multiomics landscape of synovial fibroblasts in rheumatoid arthritis","volume":"41","author":"Tsuchiya","year":"2021","journal-title":"Inflamm Regen"},{"key":"10.1136\/ard-2023-224540_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04310-9","article-title":"Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes","volume":"9","author":"Ai","year":"2018","journal-title":"Nat Commun"},{"key":"10.1136\/ard-2023-224540_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101649","article-title":"Diversity of NF-\u039aB signalling and inflammatory heterogeneity in rheumatic autoimmune disease","volume":"58","author":"Manou-Stathopoulou","year":"2021","journal-title":"Semin Immunol"},{"key":"10.1136\/ard-2023-224540_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat Genet"},{"key":"10.1136\/ard-2023-224540_bib39","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1002\/art.24982","article-title":"HLA-Dpb1 and Dpb2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans","volume":"60","author":"Zhou","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224540_bib40","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/art.38036","article-title":"Association of granulomatosis with polyangiitis (Wegener's) with HLA-Dpb1*04 and Sema6A gene variants: evidence from genome-wide analysis","volume":"65","author":"Xie","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224540_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24395","article-title":"Tumor necrosis factor-alpha stimulated gene-6: a biomarker reflecting disease activity in rheumatoid arthritis","volume":"36","author":"Hu","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"10.1136\/ard-2023-224540_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.matbio.2018.01.011","article-title":"TSG-6: a multifunctional protein with anti-inflammatory and tissue-protective properties","volume":"78\u201379","author":"Day","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1136\/ard-2023-224540_bib43","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1136\/annrheumdis-2018-213418","article-title":"Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production","volume":"77","author":"Rivellese","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224540_bib44","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1136\/annrheumdis-2020-217204","article-title":"Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association between Il18Rap expression and treatment response","volume":"79","author":"Cherlin","year":"2020","journal-title":"Ann Rheum Dis"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724003571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724003571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard-2023-224540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T08:19:13Z","timestamp":1739521153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724003571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0003496724003571"],"URL":"https:\/\/doi.org\/10.1136\/ard-2023-224540","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression quantitative trait loci analysis in rheumatoid arthritis identifies tissue specific variants associated with severity and outcome","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard-2023-224540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2024 \u00a9 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}