{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:42:54Z","timestamp":1792197774908,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202106100140"],"award-info":[{"award-number":["202106100140"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1136\/ard-2023-224679","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:21:42Z","timestamp":1692206502000},"page":"1511-1515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6828-620X","authenticated-orcid":false,"given":"HanLin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-3920","authenticated-orcid":false,"given":"Hengwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-1267","authenticated-orcid":false,"given":"YingHui","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard-2023-224679_bib1","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"key":"10.1136\/ard-2023-224679_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","article-title":"Asymptomatic hyperuricemia. risks and consequences in the normative aging study","volume":"82","author":"Campion","year":"1987","journal-title":"Am J Med"},{"key":"10.1136\/ard-2023-224679_bib3","doi-asserted-by":"crossref","first-page":"e000593","DOI":"10.1136\/rmdopen-2017-000593","article-title":"Identification of Monosodium Urate crystal deposits in patients with asymptomatic hyperuricemia using dual-energy CT","volume":"4","author":"Wang","year":"2018","journal-title":"RMD Open"},{"key":"10.1136\/ard-2023-224679_bib4","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1136\/annrheumdis-2017-212288","article-title":"Relationship between serum Urate concentration and clinically evident incident gout: an individual participant data analysis","volume":"77","author":"Dalbeth","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib5","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/rheumatology\/kez023","article-title":"Synovial fluid Leukocyte count in asymptomatic Hyperuricaemia with crystal deposition: a proof-of-concept study","volume":"58","author":"Andr\u00e9s","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard-2023-224679_bib6","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/art.39581","article-title":"Silent Monosodium Urate crystal deposits are associated with severe coronary calcification in asymptomatic hyperuricemia: an exploratory study","volume":"68","author":"Andr\u00e9s","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib7","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/art.40069","article-title":"Serum Urate levels predict joint space narrowing in non-gout patients with medial knee osteoarthritis","volume":"69","author":"Krasnokutsky","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.joca.2019.05.013","article-title":"The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third national health and nutrition examination survey","volume":"27","author":"Wang","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1136\/ard-2023-224679_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1757-1146-4-13","article-title":"Revisiting the pathogenesis of Podagra: why does gout target the foot","volume":"4","author":"Roddy","year":"2011","journal-title":"J Foot Ankle Res"},{"key":"10.1136\/ard-2023-224679_bib10","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/annrheumdis-2012-202786","article-title":"Tendon involvement in the feet of patients with gout: a dual-energy CT study","volume":"72","author":"Dalbeth","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib11","doi-asserted-by":"crossref","first-page":"e000101","DOI":"10.1136\/rmdopen-2015-000101","article-title":"Relationship between tissue stress during gait in healthy volunteers and patterns of Urate deposition and bone erosion in gout: a Biomechanical computational Modelling study","volume":"1","author":"Dalbeth","year":"2015","journal-title":"RMD Open"},{"key":"10.1136\/ard-2023-224679_bib12","first-page":"1108","article-title":"Association between crystals and cartilage degeneration in the ankle","volume":"35","author":"Muehleman","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib13","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/ard.2006.063768","article-title":"Are joints affected by gout also affected by osteoarthritis?","volume":"66","author":"Roddy","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12891-016-1032-9","article-title":"The association between gout and radiographic hand, knee and foot osteoarthritis: a cross-sectional study","volume":"17","author":"Bevis","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1136\/ard-2023-224679_bib15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/annrheumdis-2014-206410","article-title":"Comorbidities in patients with gout prior to and following diagnosis: case-control study","volume":"75","author":"Kuo","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.27301","article-title":"Clinical images: gout revealed on Arthroscopy after minor injury","volume":"62","author":"Baker","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224679_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00003086-200111000-00049","article-title":"Gout-induced Arthropathy after total knee Arthroplasty: a report of two cases","volume":"392","author":"Archibeck","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1136\/ard-2023-224679_bib18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00508-010-1384-3","article-title":"Acute gouty arthritis in a patient after total knee Arthroplasty","volume":"122","author":"Fokter","year":"2010","journal-title":"Wien Klin Wochenschr"},{"key":"10.1136\/ard-2023-224679_bib19","first-page":"4718","article-title":"Rare coexistence of gouty and septic arthritis after Arthroscopic rotator cuff repair: a case report","volume":"8","author":"Ichiseki","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1136\/ard-2023-224679_bib20","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.23495","article-title":"Decreased Lubricin concentrations and markers of joint inflammation in the Synovial fluid of patients with anterior Cruciate ligament injury","volume":"58","author":"Elsaid","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224679_bib21","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/ar1898","article-title":"Proteoglycan 4 downregulation in a sheep Meniscectomy model of early osteoarthritis","volume":"8","author":"Young","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224679_bib22","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.joca.2012.04.021","article-title":"The impact of forced joint exercise on Lubricin biosynthesis from Articular cartilage following ACL Transection and intra-Articular Lubricin's effect in exercised joints following ACL Transection","volume":"20","author":"Elsaid","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1136\/ard-2023-224679_bib23","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/art.11326","article-title":"The release of Crosslinked peptides from type II collagen into human Synovial fluid is increased soon after joint injury and in osteoarthritis","volume":"48","author":"Lohmander","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224679_bib24","first-page":"1765","article-title":"Procollagen II C-Propeptide in joint fluid: changes in concentration with age, time after knee injury, and osteoarthritis","volume":"23","author":"Lohmander","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/ard-2022-222773","article-title":"Synovial fibroblasts assume distinct functional identities and Secrete R-Spondin 2 in osteoarthritis","volume":"82","author":"Knights","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/art.42413","article-title":"Amplification of inflammation by Lubricin deficiency implicated in incident, erosive gout independent of hyperuricemia","volume":"75","author":"Elsaid","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/ard-2022-222764","article-title":"Type II collagen facilitates gouty arthritis by regulating MSU Crystallisation and inflammatory cell recruitment","volume":"82","author":"Xu","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib28","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.immuni.2021.03.003","article-title":"The complement system drives local inflammatory tissue priming by metabolic Reprogramming of Synovial fibroblasts","volume":"54","author":"Fri\u0161\u010di\u0107","year":"2021","journal-title":"Immunity"},{"key":"10.1136\/ard-2023-224679_bib29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrrheum.2015.125","article-title":"Mechanisms of crystal formation in gout-a structural approach","volume":"11","author":"Pascual","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib30","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/art.41038","article-title":"Human cartilage homogenates influence the crystallization of Monosodium Urate and inflammatory response to Monosodium Urate crystals: A potential link between osteoarthritis and gout","volume":"71","author":"Chhana","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12891-015-0762-4","article-title":"Factors influencing the crystallization of Monosodium Urate: a systematic literature review","volume":"16","author":"Chhana","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1136\/ard-2023-224679_bib32","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/art.1780230509","article-title":"Studies on the Nucleation of Monosodium Urate at 37 degrees C","volume":"23","author":"Tak","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224679_bib33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/03009742.2015.1124452","article-title":"Synovial fluid proteins are required for the induction of Interleukin-1\u0392 production by Monosodium Urate crystals","volume":"45","author":"Scanu","year":"2016","journal-title":"Scand J Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.42.1.75","article-title":"Morphological characteristics of Monosodium Urate: a transmission electron microscopic study of intact natural and synthetic crystals","volume":"42","author":"Paul","year":"1983","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib35","doi-asserted-by":"crossref","first-page":"213005","DOI":"10.1016\/j.bioadv.2022.213005","article-title":"Monosodium Urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout","volume":"139","author":"Chen","year":"2022","journal-title":"Biomater Adv"},{"key":"10.1136\/ard-2023-224679_bib36","first-page":"809","article-title":"Calcium pyrophosphate and Monosodium Urate crystal interactions with neutrophils: effect of crystal size and lipoprotein binding to crystals","volume":"16","author":"Burt","year":"1989","journal-title":"J Rheumatol"},{"key":"10.1136\/ard-2023-224679_bib37","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.7150\/thno.53755","article-title":"Highly specific and label-free histological identification of Microcrystals in fresh human gout tissues with stimulated Raman scattering","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"10.1136\/ard-2023-224679_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2016.12.004","article-title":"Quantitative Proteomics analysis of cartilage response to mechanical injury and cytokine treatment","volume":"63","author":"Wang","year":"2017","journal-title":"Matrix Biol"},{"key":"10.1136\/ard-2023-224679_bib39","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1177\/03635465231169526","article-title":"Synovial fluid Proteomics from serial aspirations of ACL-injured knees identifies candidate biomarkers","volume":"51","author":"Rai","year":"2023","journal-title":"Am J Sports Med"},{"key":"10.1136\/ard-2023-224679_bib40","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/art.1780360912","article-title":"Changes in the proteins coating Monosodium Urate crystals during active and subsiding inflammation. Immunogold studies of Synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model","volume":"36","author":"Ortiz-Bravo","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard-2023-224679_bib41","series-title":"Biomineralization","first-page":"57","article-title":"Principles of crystal Nucleation and Growth","author":"Dove","year":"2003"},{"key":"10.1136\/ard-2023-224679_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/ard.57.4.255","article-title":"Orderly arrayed deposit of Urate crystals in gout suggest Epitaxial formation","volume":"57","author":"Pascual","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib43","series-title":"Annual Review","first-page":"21","article-title":"crystallization pathways in Biomineralization","author":"Weiner","year":"2011"},{"key":"10.1136\/ard-2023-224679_bib44","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/ard.55.12.921","article-title":"Enthesopathy and Tendinopathy in gout: computed Tomographic assessment","volume":"55","author":"Gerster","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard-2023-224679_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.matbio.2014.08.008","article-title":"The biology of Lubricin: near Frictionless joint motion","volume":"39","author":"Jay","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1136\/ard-2023-224679_bib46","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1369\/0022155420940067","article-title":"The inter-\u0391-Trypsin inhibitor family: versatile molecules in biology and pathology","volume":"68","author":"Lord","year":"2020","journal-title":"J Histochem Cytochem"},{"key":"10.1136\/ard-2023-224679_bib47","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1186\/ar3216","article-title":"Changes in serum and Synovial fluid biomarkers after acute injury (Nct00332254)","volume":"12","author":"Catterall","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224679_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13075-018-1693-x","article-title":"Recombinant human Proteoglycan-4 reduces Phagocytosis of Urate crystals and downstream nuclear factor Kappa B and Inflammasome activation and production of Cytokines and Chemokines in human and murine Macrophages","volume":"20","author":"Qadri","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224679_bib49","doi-asserted-by":"crossref","first-page":"771677","DOI":"10.3389\/fimmu.2021.771677","article-title":"Recombinant human Proteoglycan 4 regulates Phagocytic activation of monocytes and reduces IL-1\u0392 secretion by Urate crystal stimulated gout Pbmcs","volume":"12","author":"ElSayed","year":"2021","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224679_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s13075-015-0877-x","article-title":"The interaction of Lubricin\/Proteoglycan 4 (Prg4) with toll-like receptors 2 and 4: an anti-inflammatory role of Prg4 in Synovial fluid","volume":"17","author":"Alquraini","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard-2023-224679_bib51","doi-asserted-by":"crossref","first-page":"938075","DOI":"10.3389\/fimmu.2022.938075","article-title":"Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis","volume":"13","author":"Sebastian","year":"2022","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2023-224679_bib52","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally renewing resident Synovial Macrophages provide a protective barrier for the joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"10.1136\/ard-2023-224679_bib53","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/art.42378","article-title":"Reset of inflammatory priming of joint tissue and reduction of the severity of arthritis flares by Bromodomain inhibition","volume":"75","author":"Fri\u0161\u010di\u0107","year":"2023","journal-title":"Arthritis Rheumatol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724083602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724083602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard-2023-224679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T23:27:07Z","timestamp":1737242827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724083602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0003496724083602"],"URL":"https:\/\/doi.org\/10.1136\/ard-2023-224679","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard-2023-224679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 \u00a9 Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}