{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:46:45Z","timestamp":1793468805614,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012517","name":"Directorate-General XII, Science, Research, and Development","doi-asserted-by":"publisher","award":["732163"],"award-info":[{"award-number":["732163"]}],"id":[{"id":"10.13039\/501100012517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1136\/ard-2024-225771","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T17:27:30Z","timestamp":1728667650000},"page":"1572-1583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Allogenic bone marrow\u2013derived mesenchymal stromal cell\u2013based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study)"],"prefix":"10.1016","volume":"83","clinical-trial-number":[{"clinical-trial-number":"nct03737461","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03737461","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-3773","authenticated-orcid":false,"given":"Yves-Marie","family":"Pers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Soler-Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Vadal\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Duflos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Picot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchon","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Broussous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Noriega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ardura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Alberca Zaballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Gordillo Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Gonz\u00e1lez-Vallinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicenzo","family":"Denaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Guicheux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Vilanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00f6rg","family":"Meisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Alfonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Rannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-8524","authenticated-orcid":false,"given":"Yves","family":"Maugars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-7815","authenticated-orcid":false,"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Tarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Louis-Plence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Ferreira-Dos-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-Sancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-8094","authenticated-orcid":false,"given":"Christian","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Thouvenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cyteval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Grasset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Renier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Cardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Robin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Seddiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Pouvreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Engrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Prosper","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Parlier","family":"Cuau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Alomar","family":"Serrallach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Feydy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Toulgoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"No\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaum","family":"Costecalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipe","family":"Bourin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo C.","family":"Quattrocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Binch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hohaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Dulong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Michon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"Bouzas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Casteilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ruckes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Kucharski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cicione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina Di","family":"Giacomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Tilotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Carassiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Buffenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Clouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard-2024-225771_bib1","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2665-9913(23)00098-X","article-title":"Global, regional, and national burden of low back pain, 1990-2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"Ferreira","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib2","doi-asserted-by":"crossref","first-page":"e90633","DOI":"10.1371\/journal.pone.0090633","article-title":"The burden of musculoskeletal conditions","volume":"9","author":"Palazzo","year":"2014","journal-title":"PLoS One"},{"key":"10.1136\/ard-2024-225771_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5312\/wjo.v4.i2.42","article-title":"Pathophysiology, diagnosis, and treatment of discogenic low back pain","volume":"4","author":"Peng","year":"2013","journal-title":"World J Orthop"},{"key":"10.1136\/ard-2024-225771_bib4","doi-asserted-by":"crossref","first-page":"970752","DOI":"10.1155\/2012\/970752","article-title":"Lumbar degenerative disc disease: current and future concepts of diagnosis and management","volume":"2012","author":"Taher","year":"2012","journal-title":"Adv Orthop"},{"key":"10.1136\/ard-2024-225771_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0140-6736(21)00733-9","article-title":"Low back pain","volume":"398","author":"Knezevic","year":"2021","journal-title":"Lancet"},{"key":"10.1136\/ard-2024-225771_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41584-020-00568-w","article-title":"Cell-based strategies for IVD repair: clinical progress and translational obstacles","volume":"17","author":"Binch","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cell.2018.07.029","article-title":"Identification of the Human Skeletal Stem Cell","volume":"175","author":"Chan","year":"2018","journal-title":"Cell"},{"key":"10.1136\/ard-2024-225771_bib8","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1007\/s00167-020-05859-z","article-title":"Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis","volume":"28","author":"Doyle","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1136\/ard-2024-225771_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4252\/wjsc.v8.i5.185","article-title":"Stem cells sources for intervertebral disc regeneration","volume":"8","author":"Vadal\u00e0","year":"2016","journal-title":"World J Stem Cells"},{"key":"10.1136\/ard-2024-225771_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","article-title":"Stem cell therapy for intervertebral disc regeneration: obstacles and solutions","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.stem.2013.09.006","article-title":"Mesenchymal stromal cells: sensors and switchers of inflammation","volume":"13","author":"Bernardo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1136\/ard-2024-225771_bib12","doi-asserted-by":"crossref","first-page":"1152207","DOI":"10.3389\/fbioe.2023.1152207","article-title":"Mesenchymal stem cell-derived secretome enhances nucleus pulposus cell metabolism and modulates extracellular matrix gene expression in vitro","volume":"11","author":"Tilotta","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1136\/ard-2024-225771_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.addr.2018.04.017","article-title":"Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies","volume":"146","author":"Clouet","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1136\/ard-2024-225771_bib14","doi-asserted-by":"crossref","first-page":"e1072","DOI":"10.1002\/jsp2.1072","article-title":"Combinatorial conditioning of adipose derived-mesenchymal stem cells enhances their neurovascular potential: implications for intervertebral disc degeneration","volume":"2","author":"Binch","year":"2019","journal-title":"JOR Spine"},{"key":"10.1136\/ard-2024-225771_bib15","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41584-023-01010-7","article-title":"Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells","volume":"19","author":"Bertolino","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.14444\/8054","article-title":"Stem Cells and Intervertebral Disc Regeneration Overview-What They Can and Can't Do","volume":"15","author":"Vadal\u00e0","year":"2021","journal-title":"Int J Spine Surg"},{"key":"10.1136\/ard-2024-225771_bib17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/TP.0b013e3182298a15","article-title":"Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study","volume":"92","author":"Orozco","year":"2011","journal-title":"Transplantation"},{"key":"10.1136\/ard-2024-225771_bib18","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/TP.0000000000001484","article-title":"Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells: a Randomized Controlled Trial","volume":"101","author":"Noriega","year":"2017","journal-title":"Transplantation"},{"key":"10.1136\/ard-2024-225771_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.spinee.2020.10.004","article-title":"Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy","volume":"21","author":"Amirdelfan","year":"2021","journal-title":"Spine J"},{"key":"10.1136\/ard-2024-225771_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/JPR.S244173","article-title":"The Modified WHO Analgesic Ladder: is It Appropriate for Chronic Non-Cancer Pain?","volume":"13","author":"Yang","year":"2020","journal-title":"J Pain Res"},{"key":"10.1136\/ard-2024-225771_bib21","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1097\/00007632-200109010-00011","article-title":"Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration","volume":"26","author":"Pfirrmann","year":"2001","journal-title":"Spine (Phila Pa 1986)"},{"key":"10.1136\/ard-2024-225771_bib22","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1097\/TP.0000000000003471","article-title":"Treatment of Degenerative Disc Disease With Allogeneic Mesenchymal Stem Cells: long-term Follow-up Results","volume":"105","author":"Noriega","year":"2021","journal-title":"Transplantation"},{"key":"10.1136\/ard-2024-225771_bib23","unstructured":"Patent number PCT\/EP2019\/074991, WO\/2020\/058324."},{"key":"10.1136\/ard-2024-225771_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1136\/ard-2024-225771_bib25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jcyt.2014.04.002","article-title":"Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications","volume":"17","author":"Wuchter","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1136\/ard-2024-225771_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12967-018-1591-7","article-title":"Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I\/II)","volume":"16","author":"Lamo-Espinosa","year":"2018","journal-title":"J Transl Med"},{"key":"10.1136\/ard-2024-225771_bib27","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1097\/00007632-200011150-00017","article-title":"The Oswestry Disability Index","volume":"25","author":"Fairbank","year":"2000","journal-title":"Spine"},{"key":"10.1136\/ard-2024-225771_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.berh.2005.03.003","article-title":"Clinically important outcomes in low back pain","volume":"19","author":"Ostelo","year":"2005","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1136\/ard-2024-225771_bib30","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/S2665-9913(21)00326-X","article-title":"Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1\/2 study","volume":"4","author":"Farge","year":"2022","journal-title":"Lancet Rheumatol"},{"key":"10.1136\/ard-2024-225771_bib31","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1001\/jama.2015.15281","article-title":"Multiple Imputation: a Flexible Tool for Handling Missing Data","volume":"314","author":"Li","year":"2015","journal-title":"JAMA"},{"key":"10.1136\/ard-2024-225771_bib32","series-title":"Multiple imputation for nonresponse in surveys","author":"Rubin","year":"1987"},{"key":"10.1136\/ard-2024-225771_bib33","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000369452","article-title":"Nucleus Pulposus Mesenchymal Stem Cells in Acidic Conditions Mimicking Degenerative Intervertebral Discs Give Better Performance than Adipose Tissue-Derived Mesenchymal Stem Cells","volume":"199","author":"Han","year":"2015","journal-title":"Cells Tissues Organs"},{"key":"10.1136\/ard-2024-225771_bib34","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00586-024-08163-3","article-title":"ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain","volume":"33","author":"Ambrosio","year":"2024","journal-title":"Eur Spine J"},{"key":"10.1136\/ard-2024-225771_bib35","doi-asserted-by":"crossref","first-page":"e1175","DOI":"10.1002\/jsp2.1175","article-title":"Cell sources proposed for nucleus pulposus regeneration","volume":"4","author":"Williams","year":"2021","journal-title":"JOR Spine"},{"key":"10.1136\/ard-2024-225771_bib36","doi-asserted-by":"crossref","first-page":"1155357","DOI":"10.3389\/fbioe.2023.1155357","article-title":"Mesenchymal stem cells can improve discogenic pain in patients with intervertebral disc degeneration: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1136\/ard-2024-225771_bib37","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1038\/s41591-023-02632-w","article-title":"Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial","volume":"29","author":"Mautner","year":"2023","journal-title":"Nat Med"},{"key":"10.1136\/ard-2024-225771_bib38","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2147\/JPR.S317697","article-title":"Placebo Effect of Sham Spine Procedures in Chronic Low Back Pain: a Systematic Review","volume":"14","author":"Jamjoom","year":"2021","journal-title":"J Pain Res"},{"key":"10.1136\/ard-2024-225771_bib39","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1097\/TP.0000000000000167","article-title":"Treatment of knee osteoarthritis with autologous mesenchymal stem cells: two-year follow-up results","volume":"97","author":"Orozco","year":"2014","journal-title":"Transplantation"},{"key":"10.1136\/ard-2024-225771_bib40","doi-asserted-by":"crossref","first-page":"e1348","DOI":"10.1002\/jsp2.1348","article-title":"A comprehensive review of cell transplantation and platelet-rich plasma therapy for the treatment of disc degeneration-related back and neck pain: a systematic evidence-based analysis","volume":"7","author":"Schol","year":"2024","journal-title":"JOR Spine"},{"key":"10.1136\/ard-2024-225771_bib41","doi-asserted-by":"crossref","first-page":"632717","DOI":"10.3389\/fcell.2021.632717","article-title":"Therapeutic Use of Mesenchymal Stromal Cells: the Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species","volume":"9","author":"Wright","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1136\/ard-2024-225771_bib42","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1097\/TXD.0000000000000724","article-title":"Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease","volume":"3","author":"Garc\u00eda-Sancho","year":"2017","journal-title":"Transplant Direct"},{"key":"10.1136\/ard-2024-225771_bib43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1136\/ard-2024-225771_bib44","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs autologous bone marrow\u2013derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial","volume":"308","author":"Hare","year":"2012","journal-title":"JAMA"},{"key":"10.1136\/ard-2024-225771_bib45","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3389\/fimmu.2019.01244","article-title":"Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients","volume":"10","author":"Avivar-Valderas","year":"2019","journal-title":"Front Immunol"},{"key":"10.1136\/ard-2024-225771_bib46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0140-6736(11)60610-7","article-title":"Non-specific low back pain","volume":"379","author":"Balagu\u00e9","year":"2012","journal-title":"The Lancet"},{"key":"10.1136\/ard-2024-225771_bib47","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1097\/BRS.0b013e3181ab5432","article-title":"2009 ISSLS Prize Winner: does Discography Cause Accelerated Progression of Degeneration Changes in the Lumbar Disc: a ten-year matched cohort study","volume":"34","author":"Carragee","year":"2009","journal-title":"Spine"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724665490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724665490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard-2024-225771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T08:51:57Z","timestamp":1739523117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724665490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0003496724665490"],"URL":"https:\/\/doi.org\/10.1136\/ard-2024-225771","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allogenic bone marrow\u2013derived mesenchymal stromal cell\u2013based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study)","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard-2024-225771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2024 \u00a9 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by Elsevier Inc on behalf of EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}