{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:30:40Z","timestamp":1756996240149,"version":"3.33.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1951,9,1]],"date-time":"1951-09-01T00:00:00Z","timestamp":-578620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1951,9,1]],"date-time":"1951-09-01T00:00:00Z","timestamp":-578620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[1951,9]]},"DOI":"10.1136\/ard.10.3.337","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T23:49:46Z","timestamp":1217288986000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rheumatoid Nodules"],"prefix":"10.1016","volume":"10","author":[{"given":"T.E.","family":"Hunt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"ref_1","first-page":"702","volume":"26","author":"Aegerter, E.; Long, J.","year":"1950","unstructured":"Aegerter, E., and Long, J. (1950). Amer. J. Path., 26, 702.","journal-title":"Amer. J. Path"},{"key":"ref_2","first-page":"1061","volume":"25","author":"Altshuler, C.H.; Angevine, D.M.","year":"1949","unstructured":"Altshuler, C. H., and Angevine, D. M. (1949). Ibid., 25, 1061.","journal-title":"Ibid"},{"key":"ref_3","first-page":"141","volume":"27","author":"Ibid","unstructured":", (1951). Ibid., 27, 141."},{"key":"ref_4","first-page":"70","volume":"30","author":"Bennett, G.A.; Zeller, J.W.; Bauer, W.","year":"1940","unstructured":"Bennett, G. A., Zeller, J. W., and Bauer, W. (1940). Arch. Path., Chicago, 30, 70.","journal-title":"Arch. Path., Chicago"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/path.1700450111","volume":"45","author":"Collins, D.H.","year":"1937","unstructured":"Collins, D. H. (1937). J. Path. Bact., 45, 97.","journal-title":"J. Path. Bact"},{"key":"ref_6","first-page":"115","volume":"27","author":"Klinge, F.","year":"1933","unstructured":"Klinge, F. (1933). Ergebn. allg. Path. path. Anat., 27 (whole vol.). Opsahl, J. C. (1949). Yale J. Biol. Med., 22, 115.","journal-title":"Ergebn. allg. Path. path. Anat"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/path.1700610204","volume":"61","author":"Penney, J.R.; Balfour, B.M.","year":"1949","unstructured":"Penney, J. R., and Balfour, B. M. (1949). J. Path. Bact., 61, 171.","journal-title":"J. Path. Bact"},{"year":"1950","author":"Plotz, C.M.; Howes, E.L.; Meyer, K.; Blunt, J.W.; Lattes, R.; Ragan, C.","key":"ref_8","unstructured":"Plotz, C. M., Howes, E. L., Meyer, K., Blunt, J. W., Lattes, R., and Ragan, C. (1950)."},{"key":"ref_9","first-page":"710","volume":"26","author":"Spain, D.M.; Molomut, N.; Haber, A.","year":"1950","unstructured":"Spain, D. M., Molomut, N., and Haber, A. (1950). Ibid., 26, 710.","journal-title":"Ibid"},{"key":"ref_10","unstructured":"Dans quatre cas graves, la vitesse de la sedimentation ne diminuait que lentement et incompletement, meme avec de fortes doses de ces hormones. Ceci est d'un interet particulier par le fait que dans nos cas de rhumatisme de gravite similaire, mais sans presence de nodules, la sedimentation globulaire se ralentissait rapidement sous l'influence de ces hormones.","article-title":"Dans quatre cas graves, la vitesse de la sedimentation ne diminuait que lentement et incompletement, meme avec de fortes doses de ces hormones. Ceci est d'un interet particulier par le fait que dans nos cas de rhumatisme de gravite similaire, mais sans presence de nodules, la sedimentation globulaire se ralentissait rapidement sous l'influence de ces hormones"},{"key":"ref_11","unstructured":"Les alterations histologiques subies par ces nodules etaient les suivantes: (a) disparition de l'oedeme mucineux de la substance basale, et l'inhibition de la transformation fibrinoide; (b) reduction frappante de la proliferation des cellules mesenchymateuses dans la zone entourant les surfaces centrales de necrose; (c) pas d'effet apparent sur les zones peripheriques de tissu fibreux.","article-title":"Les alterations histologiques subies par ces nodules etaient les suivantes: (a) disparition de l'oedeme mucineux de la substance basale, et l'inhibition de la transformation fibrinoide; (b) reduction frappante de la proliferation des cellules mesenchymateuses dans la zone entourant les surfaces centrales de necrose; (c) pas d'effet apparent sur les zones peripheriques de tissu fibreux"},{"key":"ref_12","unstructured":"On discute certaines possibilites concernant le mode d'action des hormones.","article-title":"On discute certaines possibilites concernant le mode d'action des hormones"},{"key":"ref_13","unstructured":"En seis casos de artritis reumatoide activa con presencia de n6dulos subcutaneos, la administraci6n de la ACTH o de la cortisona condujo a un notable ablandamiento y contracci6n de los n6dulos pero, con la excepci6n de un pequeno n6dulo, estas lesiones no desaparecieron.","article-title":"En seis casos de artritis reumatoide activa con presencia de n6dulos subcutaneos, la administraci6n de la ACTH o de la cortisona condujo a un notable ablandamiento y contracci6n de los n6dulos pero, con la excepci6n de un pequeno n6dulo, estas lesiones no desaparecieron"},{"key":"ref_14","unstructured":"En cuatro casos graves la velocidad de sedimentaci6n eritrocitaria disminuyo muy lenta e incompletamente, aun que en nuestros casos con dosis fuertes de las hormonas.","article-title":"En cuatro casos graves la velocidad de sedimentaci6n eritrocitaria disminuyo muy lenta e incompletamente, aun que en nuestros casos con dosis fuertes de las hormonas"},{"key":"ref_15","unstructured":"Los cambios histol6gicos inducidos en los n6dulos fueron los siguientes: (a) desaparici6n del edema mucinoso de la substancia basal, e inhibici6n de la transformaci6n fibrinoide; (b) reducci6n asombrosa en la proliferaci6n de celulas mesenquimatosas en la zona periferica de las areas centrales de necrosis; (c) ausencia de efecto aparente en las zonas perifericas del tejido fibroso.","article-title":"Los cambios histol6gicos inducidos en los n6dulos fueron los siguientes: (a) desaparici6n del edema mucinoso de la substancia basal, e inhibici6n de la transformaci6n fibrinoide; (b) reducci6n asombrosa en la proliferaci6n de celulas mesenquimatosas en la zona periferica de las areas centrales de necrosis; (c) ausencia de efecto aparente en las zonas perifericas del tejido fibroso"},{"key":"ref_16","unstructured":"Se discuten ciertas posibilidades respecto al modo de acci6n de estas hormonas.","article-title":"Se discuten ciertas posibilidades respecto al modo de acci6n de estas hormonas"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724483465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724483465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.10.3.337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T13:48:53Z","timestamp":1737553733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724483465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1951,9]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1951,9]]}},"alternative-id":["S0003496724483465"],"URL":"https:\/\/doi.org\/10.1136\/ard.10.3.337","relation":{},"ISSN":["0003-4967"],"issn-type":[{"type":"print","value":"0003-4967"}],"subject":[],"published":{"date-parts":[[1951,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rheumatoid Nodules","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.10.3.337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1951 \u00a9 THE AUTHORS. Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology, EULAR. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}