{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:55:59Z","timestamp":1787738159289,"version":"build-2784847793"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1136\/ard.2003.007013","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T20:08:12Z","timestamp":1074024492000},"page":"187-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever"],"prefix":"10.1016","volume":"63","author":[{"given":"C","family":"Sackesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bakkaloglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B E","family":"Sekerel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ozaltin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Besbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Adalioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2003.007013_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","article-title":"Human Th1 and Th2 subsets. Doubt no more","volume":"12","author":"Romagnoni","year":"1991","journal-title":"Immunol Today"},{"key":"10.1136\/ard.2003.007013_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0167-5699(95)80068-9","article-title":"Th1 and Th2 CD4+T cells in the pathogenesis of organ-specific autoimmune diseases","volume":"16","author":"Liblau","year":"1995","journal-title":"Immunol Today"},{"key":"10.1136\/ard.2003.007013_bib3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/ard.61.11.951","article-title":"Th2 mediated regulation in RA and the spondyloarthropathies","volume":"61","author":"van Roon","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.007013_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(97)09408-7","article-title":"Familial Mediterranean fever","volume":"351","author":"Ben-Chetrit","year":"1998","journal-title":"Lancet"},{"key":"10.1136\/ard.2003.007013_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00002281-199909000-00011","article-title":"Vasculopathy, Beh\u00e7et\u2019s syndrome and familial Mediterranean fever","volume":"11","author":"Ozen","year":"1999","journal-title":"Curr Opin Rheumatol"},{"key":"10.1136\/ard.2003.007013_bib6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever","volume":"90","year":"1997","journal-title":"Cell"},{"key":"10.1136\/ard.2003.007013_bib7","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1182\/blood.V95.10.3223","article-title":"The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators","volume":"95","author":"Centola","year":"2000","journal-title":"Blood"},{"key":"10.1136\/ard.2003.007013_bib8","first-page":"2011","article-title":"Th1 polarization in familial Mediterranean fever","volume":"30","author":"Aypar","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2003.007013_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1081-1206(10)61517-7","article-title":"Prevalence of asthmatic phenotypes and bronchial hyperresponsiveness in Turkish schoolchildren: an International Study of Asthma and Allergies in Childhood (ISAAC) phase 2 study","volume":"91","author":"Saraclar","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1136\/ard.2003.007013_bib10","unstructured":"Kuyucu S, Saraclar Y, Tuncer A, Sackesen C, Adalioglu G, Sumbuloglu V, Sekerel BE. Determinants of atopic sensitization in Turkish school children: effects of pre- and post-natal events and maternal atopy. Pediatr Allergy Immunol (in press)."},{"key":"10.1136\/ard.2003.007013_bib11","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1046\/j.1365-2222.1998.028s5052.x","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"28","author":"Asher","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1136\/ard.2003.007013_bib12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","article-title":"Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"10.1136\/ard.2003.007013_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.ejhg.5200674","article-title":"Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population","volume":"9","author":"Yilmaz","year":"2001","journal-title":"Eur J Hum Genet"},{"key":"10.1136\/ard.2003.007013_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ajmg.1320530210","article-title":"Possible protection against asthma in heterozygotes for familial Mediterranean fever","volume":"53","author":"Brenner-Ullman","year":"1994","journal-title":"Am J Med Genet"},{"key":"10.1136\/ard.2003.007013_bib15","first-page":"459","article-title":"Decreased incidence of asthma in patients with familial Mediterranean fever","volume":"26","author":"Danon","year":"1990","journal-title":"Isr J Med Sci"},{"key":"10.1136\/ard.2003.007013_bib16","first-page":"237","article-title":"Absence of asthma in patients with familial Mediterranean fever","volume":"30","author":"Ozy\u0131lkan","year":"1994","journal-title":"Isr J Med Sci"},{"key":"10.1136\/ard.2003.007013_bib17","unstructured":"Deanly P, Michel FB, Bousquet J. In vivo methods for study of allergy skin test, techniques and interpretation. In: Middleton EJR, ed. Allergy principles, practice. St Louis, USA: Mosby, 1998:430\u20139."},{"key":"10.1136\/ard.2003.007013_bib18","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1164\/ajrccm.156.4.9703012","article-title":"An evaluation of colchicine as an alternative to inhaled corticosteroids in moderate asthma","volume":"156","author":"Fish","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1136\/ard.2003.007013_bib19","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1164\/ajrccm.164.8.2103080","article-title":"Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype","volume":"164","author":"Salvi","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1136\/ard.2003.007013_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000235380","article-title":"CD4+ T lymphocyte activation in acute severe asthma","volume":"94","author":"Corrigan","year":"1991","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1136\/ard.2003.007013_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/ajrccm\/147.2.291","article-title":"Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma","volume":"147","author":"Cembrzynska-Nowak","year":"1993","journal-title":"Am Rev Respir Dis"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724085571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724085571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2003.007013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T04:55:21Z","timestamp":1737348921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724085571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0003496724085571"],"URL":"https:\/\/doi.org\/10.1136\/ard.2003.007013","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2003.007013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Copyright 2004 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}