{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:41:03Z","timestamp":1791096063476,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1136\/ard.2003.019877","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T18:08:06Z","timestamp":1092334086000},"page":"1079-1084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":150,"title":["Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis"],"prefix":"10.1016","volume":"63","author":[{"given":"I","family":"Vallbracht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Oppermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"F\u00f6rger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Helmke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2003.019877_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0307-742X(21)00449-5","article-title":"The role of the laboratory in rheumatology. Rheumatoid factors","volume":"9","author":"Eggeland","year":"1983","journal-title":"Clin Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib3","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-011-1670-1_37","article-title":"Autoantibodies in rheumatoid arthritis. In: van Venrooij WJ, Maini RN, eds","author":"Smolen","year":"1996","journal-title":"Manual of biological markers of disease"},{"key":"10.1136\/ard.2003.019877_bib4","first-page":"183","article-title":"A population study of rheumatoid factor in Iceland. A 5 year follow-up of 50 women with rheumatoid factor (RF)","volume":"7","author":"Thorsteinsson","year":"1975","journal-title":"Ann Clin Res"},{"key":"10.1136\/ard.2003.019877_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0021-9681(67)90009-4","article-title":"Estimates on the prevalence of rheumatic diseases in the population of Tecumseh, Michigan, 1959\u201360","volume":"20","author":"Mikkelsen","year":"1967","journal-title":"J Chron Dis"},{"key":"10.1136\/ard.2003.019877_bib6","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI117969","article-title":"The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies","volume":"95","author":"Sebbag","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.2003.019877_bib7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/ard.23.4.302","article-title":"A new serum factor in patients with rheumatoid arthritis. The perinuclear factor","volume":"23","author":"Nienhuis","year":"1964","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/ard.60.1.67","article-title":"Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis","volume":"60","author":"Mediwake","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1136\/ard.49.11.906","article-title":"Disease activity and joint damage progression in early rheumatoid arthritis: relation to IgG, IgA, and IgM rheumatoid factor","volume":"49","author":"Eberhardt","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3109\/03009748809096770","article-title":"IgA and IgM rheumatoid factors as markers of later erosive changes in rheumatoid arthritis (RA)","volume":"75","author":"Wiloch","year":"1988","journal-title":"Scand J Rheumatology"},{"key":"10.1136\/ard.2003.019877_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.2003.019877_bib12","first-page":"689","article-title":"The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis","volume":"17","author":"van","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/ard.62.2.120","article-title":"Anticitrullinated protein\/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage","volume":"62","author":"Meyer","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib15","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6","article-title":"The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis","volume":"43","author":"Kroot","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.10117","article-title":"How to diagnose rheumatoid arthritis early. A prediction model for persistent (erosive) Arthritis","volume":"46","author":"Visser","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.162.1.585","article-title":"The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues","volume":"162","author":"Girbal-Neuhauser","year":"1999","journal-title":"J Immunol"},{"key":"10.1136\/ard.2003.019877_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF00541367","article-title":"Enzyme-linked immunosorbent assay (ELISA) screening test for detection of rheumatoid factor","volume":"6","author":"Jonsson","year":"1986","journal-title":"Rheumatol Int"},{"key":"10.1136\/ard.2003.019877_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/03009748809098795","article-title":"Assessing disability in patients with rheumatoid arthritis. Use of a Swedish version of the Stanford Health Assessment Questionaire","volume":"17","author":"Ekdahl","year":"1988","journal-title":"Scand J Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/art.1780360601","article-title":"The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials","volume":"36","author":"Felson","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib21","first-page":"481","article-title":"Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films","volume":"18","author":"Larsen","year":"1977","journal-title":"Acta Radiol"},{"key":"10.1136\/ard.2003.019877_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/ar93","article-title":"Rheumatoid arthritis associated antibodies in patients with synovitis of recent onset","volume":"2","author":"Goldbach-Mansky","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2003.019877_bib23","first-page":"2208","article-title":"Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5 year followup of a prospective double-blind placebo controlled study","volume":"22","author":"Egsmose","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.7326\/0003-4819-124-8-199604150-00001","article-title":"The effectiveness of early treatment with \u201csecond-line\u201d antirheumatic drugs: A randomised, controlled trial","volume":"124","author":"Van der Heide","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2003.019877_bib25","first-page":"1072","article-title":"Longterm mortality outcome in patients with rheumatoid arthritis: early presenters continue to do well","volume":"25","author":"Symmons","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/1529-0131(200001)43:1<22::AID-ANR4>3.0.CO;2-9","article-title":"Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration","volume":"43","author":"Anderson","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(97)01300-7","article-title":"Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis","volume":"350","author":"Boers","year":"1997","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1136\/ard.2003.019877_bib28","first-page":"15","article-title":"Prognostic criteria in rheumatoid arthritis: can we predict which patients will require specific anti-rheumatoid treatment?","volume":"15","author":"Kirwan","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib29","first-page":"2074","article-title":"Rheumatoid factor and antibodies to cyclic citrullinated peptide differentiate rheumatoid arthritis from undifferentiated rheumatoid arthritis in patients with early arthritis","volume":"29","author":"Jansen","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib30","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/ard.62.9.870","article-title":"Clinical utility of the anti-CCP assay in patients with rheumatic diseases","volume":"62","author":"Lee","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03009740310003677","article-title":"High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis","volume":"32","author":"Suzuki","year":"2003","journal-title":"Scand J Rheum"},{"key":"10.1136\/ard.2003.019877_bib32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7326\/0003-4819-139-3-200308050-00021","article-title":"Anti-cyclic citrullinated peptide antibodies in advanced rheumatoid arthritis","volume":"139","author":"Pinheiro","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2003.019877_bib33","first-page":"383","article-title":"Anticitrullinated protein\/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis","volume":"60","author":"Van","year":"2002","journal-title":"Neth J Med"},{"key":"10.1136\/ard.2003.019877_bib34","first-page":"34","article-title":"Diagnosing early-onset rheumatoid arthritis: the role of anti-CCP antibodies","volume":"21","author":"Vasishta","year":"2002","journal-title":"Am Clin Lab"},{"key":"10.1136\/ard.2003.019877_bib35","first-page":"1451","article-title":"Diagnostic value of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis","volume":"30","author":"Zeng","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2003.019877_bib36","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlquist","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2003.019877_bib37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/rheumatology\/keg184","article-title":"Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis of rheumatoid arthritis","volume":"42","author":"Bas","year":"2003","journal-title":"Rheumatology"},{"key":"10.1136\/ard.2003.019877_bib38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/ard.62.5.427","article-title":"Autoantibodies can be prognostic markers of erosive disease in early rheumatoid arthritis","volume":"62","author":"Vencovsky","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/ard.60.1.32","article-title":"Association of autoantibodies to filaggrin with an active disease in early rheumatoid arthritis","volume":"60","author":"Paimela","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2003.019877_bib40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/rheumatology\/keg257","article-title":"rheumatoid factor is the strongest predictor of radiological progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients","volume":"42","author":"Vittecoq","year":"2003","journal-title":"Rheumatology"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724401659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724401659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2003.019877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:29:14Z","timestamp":1737545354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724401659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0003496724401659"],"URL":"https:\/\/doi.org\/10.1136\/ard.2003.019877","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2003.019877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Copyright 2004 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}