{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:15:56Z","timestamp":1761128156512,"version":"3.32.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1136\/ard.2004.028225","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T22:33:44Z","timestamp":1097620424000},"page":"ii28-ii31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"S2","title":["What precedes development of rheumatoid arthritis?"],"prefix":"10.1016","volume":"63","author":[{"given":"L","family":"Klareskog","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Alfredsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rantap\u00e4\u00e4-Dahlqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Berglin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Stolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Padyukov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl 3","key":"10.1136\/ard.2004.028225_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/ar566","article-title":"Genes and environment in arthritis: can RA be prevented?","volume":"4","author":"Klareskog","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2004.028225_bib2","first-page":"1282","article-title":"Rheumatoid factor antedating clinical rheumatoid arthritis.","volume":"18","author":"Aho","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2004.028225_bib3","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.","volume":"48","author":"Rantap\u00e4\u00e4-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib4","doi-asserted-by":"crossref","unstructured":"Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004;50 :380\u20136.","DOI":"10.1002\/art.20018"},{"key":"10.1136\/ard.2004.028225_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/ar95","article-title":"Citrullination: a small change for a protein with great consequences for rheumatoid arthritis.","volume":"2","author":"van","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2004.028225_bib6","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/art.11229","article-title":"Citrullination of synovial proteins in murine models of rheumatoid arthritis.","volume":"48","author":"Vossenaar","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar1184","article-title":"Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis.","volume":"6","author":"Vossenaar","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2004.028225_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/ar9","article-title":"Genetics of rheumatoid arthritis: confronting complexity.","volume":"1","author":"Gregersen","year":"1999","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2004.028225_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-857X(03)00066-8","article-title":"Gregersen PK. Rheumatoid arthritis. The genetic components.","volume":"28","author":"Jawaheer","year":"2002","journal-title":"Rheum Dis North Clin North Am"},{"key":"10.1136\/ard.2004.028225_bib11","doi-asserted-by":"crossref","unstructured":"Berglin E, Padyukov L, Sundin U, Hallmans G, Stenlund H, van Venrooij WJ, et al. A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. Arthritis Res Ther. 2004;6: R303\u20138, Epub 11 May 2004.","DOI":"10.1186\/ar1187"},{"key":"10.1136\/ard.2004.028225_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0010-7824(87)90082-5","article-title":"Oral contraceptives, cigarette smoking and other factors in relation to arthritis","volume":"35","author":"Vessey","year":"1987","journal-title":"Contraception"},{"key":"10.1136\/ard.2004.028225_bib13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.1780390504","article-title":"Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins.","volume":"39","author":"Silman","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib14","first-page":"1830","article-title":"Smoking and risk of rheumatoid arthritis.","volume":"20","author":"Heli\u00f6vaara","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2004.028225_bib15","first-page":"47","article-title":"Current tobacco smoking, formal education, and the risk of rheumatoid arthritis","volume":"26","author":"Uhlig","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2004.028225_bib16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/ard.62.9.835","article-title":"Quantification of the influence of cigarette smoking on rheumatoid arthritis.","volume":"62","author":"Stolt","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2004.028225_bib17","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/art.10174","article-title":"Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus.","volume":"46","author":"Mattey","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/art.20553","article-title":"Interaction between smoking and shared epitope genes in HLA-DR provides a high risk for seropositive rheumatoid arthritis.","author":"Padyukov","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.028225_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/oxfordjournals.aje.a113015","article-title":"Concepts of interaction.","volume":"112","author":"Rothman","year":"1980","journal-title":"Am J Epidemiol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724498476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724498476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2004.028225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:02:57Z","timestamp":1736154177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724498476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":19,"alternative-id":["S0003496724498476"],"URL":"https:\/\/doi.org\/10.1136\/ard.2004.028225","relation":{},"ISSN":["0003-4967"],"issn-type":[{"type":"print","value":"0003-4967"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What precedes development of rheumatoid arthritis?","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2004.028225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Copyright 2004 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}