{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:21:38Z","timestamp":1763684498890,"version":"3.33.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1136\/ard.2004.031674","type":"journal-article","created":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T01:13:23Z","timestamp":1107566003000},"page":"1190-1194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association of polymorphism in the transforming growth factor \u03b21 gene with disease outcome and mortality in rheumatoid arthritis"],"prefix":"10.1016","volume":"64","author":[{"given":"D L","family":"Mattey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P T","family":"Dawes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2004.031674_bib1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/1529-0131(200004)43:4<859::AID-ANR17>3.0.CO;2-Y","article-title":"Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis. Evidence for interaction with glutathione S-transferase genes","volume":"43","author":"Mattey","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib3","first-page":"2308","article-title":"A DNA polymorphism at the \u03b12 \u2013 Macroglobulin gene is associated with the severity of rheumatoid arthritis","volume":"27","author":"Zapico","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2004.031674_bib4","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/art.10336","article-title":"Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms. Association with severity and progression of rheumatoid arthritis in a prospective study","volume":"46","author":"Constantin","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1399-0039.2002.590410.x","article-title":"Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis","volume":"59","author":"Rodriguez","year":"2002","journal-title":"Tissue Antigens"},{"key":"10.1136\/ard.2004.031674_bib6","first-page":"1135","article-title":"Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis","volume":"29","author":"Brun","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2004.031674_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.gene.6363867","article-title":"A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis","volume":"3","author":"Baugh","year":"2002","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2004.031674_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.gene.6363632","article-title":"Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis","volume":"1","author":"van","year":"1999","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2004.031674_bib9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P","article-title":"Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis","volume":"42","author":"Cantagrel","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/sj.gene.6363673","article-title":"CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis","volume":"1","author":"Zapico","year":"2001","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2004.031674_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.gene.6363766","article-title":"IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels","volume":"2","author":"Buchs","year":"2001","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2004.031674_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1399-0039.2002.590208.x","article-title":"Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis","volume":"59","author":"Kaijzel","year":"2002","journal-title":"Tissue Antigens"},{"key":"10.1136\/ard.2004.031674_bib13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/ard.61.9.826","article-title":"Transforming growth factor \u03b21 gene polymorphism in rheumatoid arthritis","volume":"61","author":"Sugiura","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2004.031674_bib14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/ard.62.9.907","article-title":"Transforming growth factor \u03b21 gene (HSTGFB1) nucleotide T869C (codon 10) polymorphism is not associated with prevalence or severity of rheumatoid arthritis in a Caucasian population","volume":"62","author":"Pokorny","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2004.031674_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1084\/jem.169.1.291","article-title":"Active and latent forms of transforming growth factor beta activity in synovial effusions","volume":"169","author":"Fava","year":"1989","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2004.031674_bib16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2249.1990.tb03331.x","article-title":"Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures","volume":"81","author":"Brennan","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2004.031674_bib17","first-page":"620","article-title":"Enhanced expression of transforming growth factor-betas and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis","volume":"70","author":"Taketazu","year":"1994","journal-title":"Lab Invest"},{"key":"10.1136\/ard.2004.031674_bib18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2004.031674_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/8.1.93","article-title":"Genetic control of the circulating concentration of transforming growth factor type beta1","volume":"8","author":"Grainger","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1136\/ard.2004.031674_bib20","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1161\/01.CIR.101.24.2783","article-title":"Association of a T29\u2192C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese","volume":"101","author":"Yokota","year":"2000","journal-title":"Circulation"},{"key":"10.1136\/ard.2004.031674_bib21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1136\/ard.61.8.678","article-title":"Analysis of transforming growth factor beta1 gene polymorphisms in patients with systemic sclerosis","volume":"61","author":"Crilly","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2004.031674_bib22","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1046\/j.1523-1755.2003.00919.x","article-title":"Association of transforming growth factor-beta (TGF-beta) T869C (Leu10Pro) gene polymorphisms with type 2 diabetic nephropathy in Chinese","volume":"63","author":"Wong","year":"2003","journal-title":"Kidney Int"},{"key":"10.1136\/ard.2004.031674_bib23","first-page":"2610","article-title":"Transforming growth factor beta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer","volume":"63","author":"Dunning","year":"2003","journal-title":"Cancer Res"},{"key":"10.1136\/ard.2004.031674_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/thorax.2003.005769","article-title":"Transforming growth factor-beta(1) genotype and susceptibility to chronic obstructive pulmonary disease","volume":"59","author":"Wu","year":"2004","journal-title":"Thorax"},{"key":"10.1136\/ard.2004.031674_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/carcin\/bgg197","article-title":"Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10","volume":"25","author":"Li","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1136\/ard.2004.031674_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1164\/rccm.200307-973OC","article-title":"Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma","volume":"169","author":"Silverman","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1136\/ard.2004.031674_bib27","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1359\/jbmr.1998.13.10.1569","article-title":"Association of a polymorphism of the transforming growth factor-beta 1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women","volume":"13","author":"Yamada","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1136\/ard.2004.031674_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002230020024","article-title":"Association of transforming growth factor-beta1 (TGFbeta1) T29\u2192C gene polymorphism with bone mineral density (BMD), changes in BMD, and serum concentrations of TGF-beta1 in a population-based sample of postmenopausal German women","volume":"69","author":"Hinke","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"10.1136\/ard.2004.031674_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/thorax.55.6.459","article-title":"TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis","volume":"55","author":"Arkwright","year":"2000","journal-title":"Thorax"},{"key":"10.1136\/ard.2004.031674_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib31","first-page":"481","article-title":"Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films","volume":"18","author":"Larsen","year":"1977","journal-title":"Acta Radiol (Stockh)"},{"key":"10.1136\/ard.2004.031674_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/art.1780230202","article-title":"Measurement of patient outcome in arthritis","volume":"23","author":"Fries","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0966-3274(99)80030-6","article-title":"ARMS-PCR methodologies to determine IL-10, TNF-\u03b1, TNF-\u03b2 and TGF\u03b21 gene polymorphisms","volume":"7","author":"Perrey","year":"1999","journal-title":"Transplant Immunol"},{"key":"10.1136\/ard.2004.031674_bib34","first-page":"601","volume":"86","author":"Hassell","year":"1993","journal-title":"Q J Med"},{"key":"10.1136\/ard.2004.031674_bib35","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/1529-0131(200007)43:7<1473::AID-ANR9>3.0.CO;2-N","article-title":"Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis","volume":"43","author":"Plant","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2004.031674_bib36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S8756-3282(03)00158-3","article-title":"The T869C TGF beta polymorphism is associated with fracture, bone mineral density, and calcaneal quantitative ultrasound in elderly women","volume":"33","author":"Dick","year":"2003","journal-title":"Bone"},{"key":"10.1136\/ard.2004.031674_bib37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00774-003-0463-1","article-title":"Osteoporosis and transforming growth factor-beta-1 gene polymorphism in Chinese men and women","volume":"22","author":"Lau","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"10.1136\/ard.2004.031674_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0002-9343(02)01393-1","article-title":"No association between the TGF-beta 1 Leu10Pro polymorphism and osteoporosis among white women in the United States","volume":"114","author":"Ziv","year":"2003","journal-title":"Am J Med"},{"key":"10.1136\/ard.2004.031674_bib39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/rheumatology\/40.4.447","article-title":"Mortality in rheumatoid arthritis: Relationship to single and composite measures of disease activity","volume":"40","author":"Chehata","year":"2001","journal-title":"Rheumatology"},{"key":"10.1136\/ard.2004.031674_bib40","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/emm.2003.27","article-title":"Association of transforming growth factor-beta1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection","volume":"35","author":"Kim","year":"2003","journal-title":"Exp Mol Med"},{"key":"10.1136\/ard.2004.031674_bib41","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1001\/jama.285.22.2859","article-title":"Association between the T29\u2192C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures","volume":"285","author":"Ziv","year":"2001","journal-title":"JAMA"},{"key":"10.1136\/ard.2004.031674_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02967627","article-title":"Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women.","volume":"10","author":"Hishida","year":"2003","journal-title":"Breast Cancer"},{"key":"10.1136\/ard.2004.031674_bib43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3835(03)00468-3","article-title":"The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk","volume":"201","author":"Krippl","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1136\/ard.2004.031674_bib44","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1158\/1055-9965.412.13.3","article-title":"T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study","volume":"13","author":"Le","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1136\/ard.2004.031674_bib45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1158\/0008-5472.CAN-03-3492","article-title":"Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study","volume":"64","author":"Shu","year":"2004","journal-title":"Cancer Res"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724429002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724429002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2004.031674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T05:20:27Z","timestamp":1737264027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724429002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0003496724429002"],"URL":"https:\/\/doi.org\/10.1136\/ard.2004.031674","relation":{},"ISSN":["0003-4967"],"issn-type":[{"type":"print","value":"0003-4967"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of polymorphism in the transforming growth factor \u03b21 gene with disease outcome and mortality in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2004.031674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Copyright 2005 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}