{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:54:23Z","timestamp":1791154463859,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1136\/ard.2005.049403","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T20:34:54Z","timestamp":1142454894000},"page":"1219-1222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":265,"title":["Citrullination is an inflammation-dependent process"],"prefix":"10.1016","volume":"65","author":[{"given":"D","family":"Makrygiannakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"af Klint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I E","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"L\u00f6fberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-K","family":"Ulfgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Klareskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Catrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2005.049403_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049403_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1523-1747.2003.12138.x","article-title":"Changing pattern of deiminated proteins in developing human epidermis","volume":"120","author":"Tsuji","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1136\/ard.2005.049403_bib3","doi-asserted-by":"crossref","first-page":"27893","DOI":"10.1074\/jbc.272.44.27893","article-title":"The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases","volume":"272","author":"Tarcsa","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1136\/ard.2005.049403_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1172\/JCI117300","article-title":"Myelin in multiple sclerosis is developmentally immature","volume":"94","author":"Moscarello","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1136\/ard.2005.049403_bib5","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/1529-0131(200110)44:10<2255::AID-ART388>3.0.CO;2-#","article-title":"Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies","volume":"44","author":"Baeten","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049403_bib6","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.20584","article-title":"The presence of citrullinated proteins is not specific for rheumatoid synovial tissue","volume":"50","author":"Vossenaar","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049403_bib7","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.4049\/jimmunol.174.8.5057","article-title":"Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides","volume":"174","author":"Chapuy-Regaud","year":"2005","journal-title":"J Immunol"},{"key":"10.1136\/ard.2005.049403_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/cne.20529","article-title":"Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis","volume":"486","author":"Raijmakers","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1136\/ard.2005.049403_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jnr.20431","article-title":"Abnormal accumulation of deiminated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer\u2019s disease","volume":"80","author":"Ishigami","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1136\/ard.2005.049403_bib10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0003-2697(92)90047-B","article-title":"Detection of citrulline residues in deiminated proteins on polyvinylidene difluoride membrane","volume":"203","author":"Senshu","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1136\/ard.2005.049403_bib11","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/art.21220","article-title":"Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity","volume":"52","author":"De Rycke","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049403_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/00365528708991491","article-title":"Histologic and colonoscopic assessment of disease extension in ulcerative colitis","volume":"22","author":"Floren","year":"1987","journal-title":"Scand J Gastroenterol"},{"key":"10.1136\/ard.2005.049403_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar1184","article-title":"Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis","volume":"6","author":"Vossenaar","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2005.049403_bib14","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1084\/jem.20042321","article-title":"Impaired early B cell tolerance in patients with rheumatoid arthritis","volume":"201","author":"Samuels","year":"2005","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2005.049403_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.171.2.538","article-title":"Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule","volume":"171","author":"Hill","year":"2003","journal-title":"J Immunol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724200583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724200583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2005.049403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T09:27:31Z","timestamp":1736069251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724200583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0003496724200583"],"URL":"https:\/\/doi.org\/10.1136\/ard.2005.049403","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Citrullination is an inflammation-dependent process","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2005.049403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Copyright 2006 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}