{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:26:21Z","timestamp":1791120381858,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1136\/ard.2005.049676","type":"journal-article","created":{"date-parts":[[2006,8,4]],"date-time":"2006-08-04T00:25:14Z","timestamp":1154651114000},"page":"1163-1167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women"],"prefix":"10.1016","volume":"65","author":[{"given":"L A","family":"Criswell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K G","family":"Saag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T R","family":"Mikuls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Cerhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Woehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Seldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2005.049676_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/1529-0131(199906)42:6<1071::AID-ANR1>3.0.CO;2-8","article-title":"The genetics revolution and the assault on rheumatoid arthritis","volume":"42","author":"Seldin","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib2","doi-asserted-by":"crossref","first-page":"10746","DOI":"10.1073\/pnas.95.18.10746","article-title":"New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study","volume":"95","author":"Cornelis","year":"1998","journal-title":"Proc Natl Acad Sc USAi"},{"key":"10.1136\/ard.2005.049676_bib3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/art.10989","article-title":"Screening the genome for rheumatoid arthritis susceptibility genes. A replication study and combined analysis of 512 multicase families","volume":"48","author":"Jawaheer","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1086\/422195","article-title":"Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites","volume":"75","author":"John","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1136\/ard.2005.049676_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.gene.6364295","article-title":"High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33","volume":"7","author":"Amos","year":"2006","journal-title":"Genes Immun"},{"issue":"suppl 3","key":"10.1136\/ard.2005.049676_bib6","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1186\/ar578","article-title":"Epidemiology and genetics of rheumatoid arthritis","volume":"4","author":"Silman","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2005.049676_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.gene.6364045","article-title":"A review of the MHC genetics of rheumatoid arthritis","volume":"5","author":"Newton","year":"2004","journal-title":"Genes Immun"},{"key":"10.1136\/ard.2005.049676_bib8","first-page":"899","article-title":"Occurrence of rheumatoid arthritis in a nationwide series of twins","volume":"13","author":"Aho","year":"1986","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/rheumatology\/32.10.903","article-title":"Twin concordance rates for rheumatoid arthritis: results from a nationwide study","volume":"32","author":"Silman","year":"1993","journal-title":"Br J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib10","first-page":"47","article-title":"Current tobacco smoking, formal education, and the risk of rheumatoid arthritis","volume":"26","author":"Uhlig","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/ard.60.3.223","article-title":"Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA","volume":"60","author":"Hutchinson","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2005.049676_bib12","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/1529-0131(199905)42:5<910::AID-ANR9>3.0.CO;2-D","article-title":"A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals","volume":"42","author":"Karlson","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0002-9343(02)01051-3","article-title":"Cigarette smoking and risk of elderly onset rheumatoid arthritis: results from the Iowa Women\u2019s Health Study","volume":"112","author":"Criswell","year":"2002","journal-title":"Am J Med"},{"key":"10.1136\/ard.2005.049676_bib14","first-page":"1282","article-title":"Rheumatoid factor antedating clinical rheumatoid arthritis","volume":"18","author":"Aho","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(73)91037-4","article-title":"Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Brusselton population","volume":"2","author":"Mathews","year":"1973","journal-title":"Lancet"},{"key":"10.1136\/ard.2005.049676_bib16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/ard.49.10.753","article-title":"Smoking, lung function, and rheumatoid arthritis","volume":"49","author":"Tuomi","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2005.049676_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/carcin\/11.1.33","article-title":"Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study","volume":"11","author":"Seidegard","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1136\/ard.2005.049676_bib18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/carcin\/16.7.1655","article-title":"Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset","volume":"16","author":"Chenevix-Trench","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1136\/ard.2005.049676_bib19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/art.10174","article-title":"Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus","volume":"46","author":"Mattey","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib20","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/oxfordjournals.aje.a115570","article-title":"Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women","volume":"131","author":"Folsom","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1136\/ard.2005.049676_bib21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/jama.1993.03500040049035","article-title":"Body fat distribution and 5-year risk of death in older women","volume":"269","author":"Folsom","year":"1993","journal-title":"JAMA"},{"key":"10.1136\/ard.2005.049676_bib22","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2105\/AJPH.85.8_Pt_1.1128","article-title":"Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women","volume":"85","author":"Folsom","year":"1995","journal-title":"Am J Public Health"},{"key":"10.1136\/ard.2005.049676_bib23","first-page":"246","article-title":"Blood transfusion, alcohol use and anthropometric risk factors for elderly onset rheumatoid arthritis in women","volume":"29","author":"Cerhan","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/aje\/kwf205","article-title":"Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women","volume":"157","author":"Cerhan","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1136\/ard.2005.049676_bib25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/art.11434","article-title":"Vitamin D intake and rheumatoid arthritis: results from the Iowa Women\u2019s Health Study","volume":"50","author":"Merlino","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib27","first-page":"1420","article-title":"A comparison of the performance of different methods of disease classification for rheumatoid arthritis. Results of an analysis from a nationwide twin study","volume":"21","author":"MacGregor","year":"1994","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2005.049676_bib28","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/carcin\/14.9.1821","article-title":"Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer","volume":"14","author":"Zhong","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1136\/ard.2005.049676_bib29","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1002\/art.10485","article-title":"HLA-DRB1 genotype associations in 793 white patients from a rheumatoid arthritis inception cohort: frequency, severity, and treatment bias","volume":"46","author":"Fries","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-642-46870-4_4","article-title":"Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility","volume":"154","author":"Hengstler","year":"1998","journal-title":"Recent Results Cancer Res"},{"key":"10.1136\/ard.2005.049676_bib31","first-page":"1239","article-title":"Metabolic gene polymorphism frequencies in control populations","volume":"10","author":"Garte","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1136\/ard.2005.049676_bib32","series-title":"Health United States, 1990","year":"1991"},{"key":"10.1136\/ard.2005.049676_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/1529-0131(200201)46:1<83::AID-ART10042>3.0.CO;2-D","article-title":"Coffee, tea and caffeine consumption and risk of rheumatoid arthritis","volume":"46","author":"Mikuls","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/ard.58.3.164","article-title":"Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope","volume":"58","author":"Mattey","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2005.049676_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/ard.53.1.51","article-title":"Serum antioxidants and risk of rheumatoid arthritis","volume":"53","author":"Heliovaara","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2005.049676_bib36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/ard.56.5.323","article-title":"Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus","volume":"56","author":"Comstock","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2005.049676_bib37","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1002\/art.20553","article-title":"A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis","volume":"50","author":"Padyukov","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2005.049676_bib38","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/(SICI)1097-0215(19970529)71:5<800::AID-IJC18>3.0.CO;2-B","article-title":"Family history and the risk of breast cancer: a systematic review and meta-analysis","volume":"71","author":"Pharoah","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1136\/ard.2005.049676_bib39","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/aje\/152.12.1154","article-title":"Familial breast and ovarian cancer: a Swedish population-based register study","volume":"152","author":"Anderson","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1136\/ard.2005.049676_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7326\/0003-4819-123-3-199508010-00004","article-title":"Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope)","volume":"123","author":"McDaniel","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2005.049676_bib41","first-page":"1363","article-title":"HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the \u201cshared epitope\u201d hypothesis may not apply","volume":"23","author":"Teller","year":"1996","journal-title":"J Rheumatol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724200479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724200479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2005.049676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T01:18:46Z","timestamp":1737249526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724200479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0003496724200479"],"URL":"https:\/\/doi.org\/10.1136\/ard.2005.049676","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2005.049676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Copyright 2006 by Annals of the Rheumatic Diseases, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}