{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:44Z","timestamp":1789168544691,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1136\/ard.2007.073502","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T20:14:23Z","timestamp":1187381663000},"page":"518-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis"],"prefix":"10.1016","volume":"67","author":[{"given":"M M","family":"Harnett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D E","family":"Kean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Boitelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"McGuiness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Thalhamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C N","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Al-Riyami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Alcocer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Houston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Gracie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I B","family":"McInnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2007.073502_bib1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S1521-6942(03)00047-0","article-title":"Rheumatoid arthritis in the developing world","volume":"17","author":"Kalla","year":"2003","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1136\/ard.2007.073502_bib2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.pt.2004.04.010","article-title":"Infection and autoimmunity: are we winning the war, only to lose the peace?","volume":"20","author":"Cooke","year":"2004","journal-title":"Trends Parasitol"},{"key":"10.1136\/ard.2007.073502_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1389203033380368","article-title":"Structural\/functional aspects of ES-62\u2014a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein","volume":"4","author":"Harnett","year":"2003","journal-title":"Curr Protein Pept Sci"},{"key":"10.1136\/ard.2007.073502_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.imlet.2004.04.008","article-title":"ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential","volume":"94","author":"Harnett","year":"2004","journal-title":"Immunol Lett"},{"key":"10.1136\/ard.2007.073502_bib5","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.171.4.2127","article-title":"A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62","volume":"171","author":"McInnes","year":"2003","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0167-5699(98)01419-4","article-title":"Phosphorylcholine: friend or foe of the immune system?","volume":"20","author":"Harnett","year":"1999","journal-title":"Immunol Today"},{"key":"10.1136\/ard.2007.073502_bib7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1365-3024.1999.00267.x","article-title":"Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein","volume":"21","author":"Harnett","year":"1999","journal-title":"Parasite Immunol"},{"key":"10.1136\/ard.2007.073502_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1365-2567.2003.01661.x","article-title":"Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo","volume":"109","author":"Wilson","year":"2003","journal-title":"Immunology"},{"key":"10.1136\/ard.2007.073502_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2567.2005.02167.x","article-title":"Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62","volume":"115","author":"Goodridge","year":"2005","journal-title":"Immunology"},{"key":"10.1136\/ard.2007.073502_bib10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.174.1.284","article-title":"Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62","volume":"174","author":"Goodridge","year":"2005","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0031182005009005","article-title":"Lack of immunological cross-reactivity between parasite-derived and recombinant forms of ES-62, a secreted protein of Acanthocheilonema viteae","volume":"132","author":"Egan","year":"2006","journal-title":"Parasitology"},{"key":"10.1136\/ard.2007.073502_bib12","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.4049\/jimmunol.175.9.5817","article-title":"ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo","volume":"175","author":"Marshall","year":"2005","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.4049\/jimmunol.177.3.1561","article-title":"Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA81","volume":"177","author":"Kean","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1136\/ard.2007.073502_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nm0297-189","article-title":"Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis","volume":"3","author":"McInnes","year":"1997","journal-title":"Nat Med"},{"key":"10.1136\/ard.2007.073502_bib15","first-page":"117","article-title":"Macrophage inflammatory proteins 1 and 2: an overview","volume":"4","author":"Sherry","year":"1992","journal-title":"Cytokines"},{"key":"10.1136\/ard.2007.073502_bib16","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1084\/jem.180.6.2039","article-title":"Expression of the chemokine N51\/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells","volume":"180","author":"Lira","year":"1994","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2007.073502_bib17","first-page":"861","article-title":"Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo","volume":"142","author":"Ohmori","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1136\/ard.2007.073502_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00024382-200206000-00013","article-title":"CXC chemokine expression after stimulation with interferon-gamma in primary rat hepatocytes in culture","volume":"17","author":"Ren","year":"2002","journal-title":"Shock"},{"key":"10.1136\/ard.2007.073502_bib19","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.162.8.4928","article-title":"Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils","volume":"162","author":"Gasperini","year":"1999","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cytogfr.2005.01.004","article-title":"Fibroblast growth factor\/fibroblast growth factor receptor system in angiogenesis","volume":"16","author":"Presta","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1136\/ard.2007.073502_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/ar115","article-title":"Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells","volume":"2","author":"McInnes","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2007.073502_bib22","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4049\/jimmunol.143.5.1537","article-title":"Collagen-induced arthritis in Biozzi mice. Joint involvement is not correlated with collagen II IgG2a autoantibodies nor restricted to only H-2q and H-2r","volume":"143","author":"Bouvet","year":"1989","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib23","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.4049\/jimmunol.163.10.5298","article-title":"NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response","volume":"163","author":"Satoskar","year":"1999","journal-title":"J Immunol"},{"key":"10.1136\/ard.2007.073502_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1136\/ard.2007.073502_bib25","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1084\/jem.179.5.1517","article-title":"Immunoregulatory role of interleukin 10 in rheumatoid arthritis","volume":"179","author":"Katsikis","year":"1994","journal-title":"J Exp Med"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724218483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724218483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2007.073502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T20:38:55Z","timestamp":1737232735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724218483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0003496724218483"],"URL":"https:\/\/doi.org\/10.1136\/ard.2007.073502","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2007.073502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 2008 Published by Elsevier Inc. Publishing Group and European League Against Rheumatism. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}