{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:24:14Z","timestamp":1790623454747,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T00:00:00Z","timestamp":1219276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1136\/ard.2007.086728","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T20:26:24Z","timestamp":1219436784000},"page":"1316-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis"],"prefix":"10.1016","volume":"68","author":[{"given":"C A","family":"Wijbrandts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S I","family":"van Leuven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H D","family":"Boom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Gerlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E G S","family":"Stroes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J P","family":"Kastelein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2007.086728_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/rheumatology\/kem202","article-title":"Systemic inflammation as a risk factor for atherothrombosis","volume":"47","author":"van Leuven","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2007.086728_bib2","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1161\/01.CIR.0000099844.31524.05","article-title":"Explaining how \u201chigh-grade\u201d systemic inflammation accelerates vascular risk in rheumatoid arthritis","volume":"108","author":"Sattar","year":"2003","journal-title":"Circulation"},{"key":"10.1136\/ard.2007.086728_bib3","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1136\/ard.2007.086728_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrd2029","article-title":"MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis","volume":"5","author":"Morand","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1136\/ard.2007.086728_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.atherosclerosis.2007.12.025","article-title":"Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: Results from the MONICA\/KORA Augsburg case\u2013cohort study, 1984\u20132002","volume":"200","author":"Herder","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1136\/ard.2007.086728_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.amjmed.2004.04.010","article-title":"Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC\u2013Norfolk Prospective Population study","volume":"117","author":"Boekholdt","year":"2004","journal-title":"Am J Med"},{"key":"10.1136\/ard.2007.086728_bib7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat Med"},{"key":"10.1136\/ard.2007.086728_bib8","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.179.6.1895","article-title":"The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor","volume":"179","author":"Calandra","year":"1994","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2007.086728_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cyto.2006.10.011","article-title":"MIF production by dendritic cells is differentially regulated by Toll-like receptors and increased during rheumatoid arthritis","volume":"36","author":"Popa","year":"2006","journal-title":"Cytokine"},{"key":"10.1136\/ard.2007.086728_bib10","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1161\/CIRCULATIONAHA.107.697789","article-title":"Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque","volume":"116","author":"Niessner","year":"2007","journal-title":"Circulation"},{"key":"10.1136\/ard.2007.086728_bib11","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1161\/hc5001.100631","article-title":"Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL","volume":"104","author":"Xu","year":"2001","journal-title":"Circulation"},{"key":"10.1136\/ard.2007.086728_bib12","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(02)08213-2","article-title":"Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study","volume":"359","author":"Choi","year":"2002","journal-title":"Lancet"},{"key":"10.1136\/ard.2007.086728_bib13","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1186\/ar2045","article-title":"Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study","volume":"8","author":"van Halm","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1136\/ard.2007.086728_bib14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/ard.2006.062497","article-title":"Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis","volume":"66","author":"Jacobsson","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2007.086728_bib15","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/art.22809","article-title":"Reduction in the incidence of myocardial infarction in patients with rheumatoid arthritis who respond to anti-tumor necrosis factor alpha therapy: results from the British Society for Rheumatology Biologics Register","volume":"56","author":"Dixon","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib16","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1136\/ard.2006.066191","article-title":"Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis","volume":"66","author":"Popa","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2007.086728_bib17","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/1529-0131(199908)42:8<1601::AID-ANR6>3.0.CO;2-B","article-title":"Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids","volume":"42","author":"Leech","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib18","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/art.20470","article-title":"Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice","volume":"50","author":"Gregory","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib19","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/art.11098","article-title":"Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue","volume":"48","author":"Smeets","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/cyto.1998.0402","article-title":"High expression of macrophage migration inhibitory factor in the synovial tissues of rheumatoid joints","volume":"11","author":"Onodera","year":"1999","journal-title":"Cytokine"},{"key":"10.1136\/ard.2007.086728_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/01.CIR.0000109201.72441.09","article-title":"Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice","volume":"109","author":"Schober","year":"2004","journal-title":"Circulation"},{"key":"10.1136\/ard.2007.086728_bib22","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-05-2011","article-title":"Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB","volume":"107","author":"Amin","year":"2006","journal-title":"Blood"},{"key":"10.1136\/ard.2007.086728_bib23","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1002\/art.21285","article-title":"Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor","volume":"52","author":"Radstake","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/ard.2004.026534","article-title":"Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis","volume":"64","author":"Kiortsis","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2007.086728_bib25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.1780390702","article-title":"Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis","volume":"39","author":"Tak","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/art.1780390703","article-title":"Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis","volume":"39","author":"Paleolog","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib27","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/01.CIR.0000037521.71373.44","article-title":"Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis","volume":"106","author":"Hurlimann","year":"2002","journal-title":"Circulation"},{"key":"10.1136\/ard.2007.086728_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L","article-title":"Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis","volume":"43","author":"Taylor","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib29","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/1529-0131(200011)43:11<2391::AID-ANR3>3.0.CO;2-F","article-title":"Systemic anti-tumor necrosis factor alpha therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor alpha synthesis","volume":"43","author":"Ulfgren","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2007.086728_bib30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/rheumatology\/41.5.558","article-title":"Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations","volume":"41","author":"Morand","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2007.086728_bib31","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1161\/01.ATV.0000143933.20616.1b","article-title":"Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice","volume":"24","author":"Branen","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1136\/ard.2007.086728_bib32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.atherosclerosis.2005.05.024","article-title":"Anti-TNF therapy and plasma HDL cholesterol concentration","volume":"182","author":"Popa","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1136\/ard.2007.086728_bib33","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1182\/blood.V97.8.2381","article-title":"Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes","volume":"97","author":"Hyka","year":"2001","journal-title":"Blood"},{"key":"10.1136\/ard.2007.086728_bib34","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/clinchem\/45.7.1039","article-title":"Lipoprotein(a)-cholesterol and coronary heart disease in the Framingham Heart Study","volume":"45","author":"Seman","year":"1999","journal-title":"Clin Chem"},{"key":"10.1136\/ard.2007.086728_bib35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0021-9150(02)00026-6","article-title":"Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study","volume":"163","author":"Luc","year":"2002","journal-title":"Atherosclerosis"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2007.086728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:49:40Z","timestamp":1739504980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724216885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0003496724216885"],"URL":"https:\/\/doi.org\/10.1136\/ard.2007.086728","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1119491.575654","asserted-by":"object"}]},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2007.086728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 \u00a9 Wijbrandts et al 2009, Published by Elsevier Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}