{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:55:20Z","timestamp":1790819720752,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1136\/ard.2008.088120","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T00:45:15Z","timestamp":1216773915000},"page":"1345-1351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls"],"prefix":"10.1016","volume":"68","author":[{"given":"L","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L B","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-J","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S Hill","family":"Gaston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2008.088120_bib1","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1002\/eji.200526162","article-title":"Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function","volume":"35","author":"Jarvis","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1136\/ard.2008.088120_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","article-title":"Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease","volume":"212","author":"Sakaguchi","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1136\/ard.2008.088120_bib3","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1038\/nprot.2007.258","article-title":"In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells","volume":"2","author":"Fantini","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1136\/ard.2008.088120_bib4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.smim.2006.01.007","article-title":"Tr1 cells: from discovery to their clinical application","volume":"18","author":"Battaglia","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1136\/ard.2008.088120_bib5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4049\/jimmunol.178.1.172","article-title":"Th3 cells in peripheral tolerance. II. TGF-\u03b2-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity","volume":"178","author":"Carrier","year":"2007","journal-title":"J Immunol"},{"key":"10.1136\/ard.2008.088120_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/08830180601070195","article-title":"Invariant NKT cells and tolerance","volume":"26","author":"Nowak","year":"2007","journal-title":"Int Rev Immunol"},{"key":"10.1136\/ard.2008.088120_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri1030","article-title":"Immunoregulation in the tissues by \u03b3\u03b4 T cells","volume":"3","author":"Hayday","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1136\/ard.2008.088120_bib8","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1053\/j.gastro.2006.09.008","article-title":"CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice","volume":"131","author":"Menager-Marcq","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1136\/ard.2008.088120_bib9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0198-8859(02)00446-9","article-title":"The nature and mechanisms of DN regulatory T-cell mediated suppression","volume":"63","author":"Young","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1136\/ard.2008.088120_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.humimm.2006.07.013","article-title":"Regulatory T cells and transplantation tolerance","volume":"67","author":"Jiang","year":"2006","journal-title":"Hum Immunol"},{"key":"10.1136\/ard.2008.088120_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.jid.5700004","article-title":"Regulatory T cells","volume":"126","author":"Beissert","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1136\/ard.2008.088120_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.0105-2896.2006.00417.x","article-title":"Human regulatory T cells and their role in autoimmune disease","volume":"212","author":"Baecher-Allan","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1136\/ard.2008.088120_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2796.2007.01836.x","article-title":"Regulatory T cells in health and disease","volume":"262","author":"Rouse","year":"2007","journal-title":"J Intern Med"},{"key":"10.1136\/ard.2008.088120_bib14","first-page":"393","article-title":"New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases","volume":"69","author":"Latinne","year":"2006","journal-title":"Acta Gastroenterol Belg"},{"key":"10.1136\/ard.2008.088120_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2177\/jsci.29.37","article-title":"The role of CD4+CD25+ regulatory T cells in patients with rheumatoid arthritis [in Japanese]","volume":"29","author":"Minami","year":"2006","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"10.1136\/ard.2008.088120_bib16","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.178.4.2579","article-title":"Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus","volume":"178","author":"Valencia","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"10.1136\/ard.2008.088120_bib17","doi-asserted-by":"crossref","first-page":"I10","DOI":"10.1007\/s00415-007-1003-z","article-title":"Regulatory mechanisms of the immune system in multiple sclerosis. T regulatory cells: turned on to turn off","volume":"254","author":"Kasper","year":"2007","journal-title":"J Neurol"},{"key":"10.1136\/ard.2008.088120_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-1759(01)00565-8","article-title":"Cell surface phenotyping and cytokine production of Epstein-Barr Virus (EBV)-transformed lymphoblastoid cell lines (LCLs)","volume":"264","author":"Wroblewski","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1136\/ard.2008.088120_bib19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cgh.2007.05.002","article-title":"Replication of an association between IL23R gene polymorphism with inflammatory bowel disease","volume":"5","author":"Oliver","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1136\/ard.2008.088120_bib20","doi-asserted-by":"crossref","first-page":"28677","DOI":"10.1074\/jbc.M300456200","article-title":"An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding","volume":"278","author":"Cui","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1136\/ard.2008.088120_bib21","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng.2007.17","article-title":"Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants","volume":"39","year":"2007","journal-title":"Nat Genetics"},{"key":"10.1136\/ard.2008.088120_bib22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/rheumatology\/ken089","article-title":"Increased IL-4+CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis","volume":"47","author":"Baek","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2008.088120_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/08820130601015775","article-title":"Induction of auto-reactive regulatory T cells by stimulation with immature autologous dendritic cells","volume":"36","author":"Jin","year":"2007","journal-title":"Immunol Invest"},{"key":"10.1136\/ard.2008.088120_bib24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/eji.200635997","article-title":"Interaction of HLA-B27 homodimers with KIR3DL1 and KIR3DL2, unlike HLA-B27 heterotrimers, is independent of the sequence of bound peptide","volume":"37","author":"Kollnberger","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1136\/ard.2008.088120_bib25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/01.tp.0000250731.44913.ee","article-title":"Targeting acute allograft rejection by immunotherapy with ex vivo-expanded natural CD4+ CD25+ regulatory T cells","volume":"82","author":"Xia","year":"2006","journal-title":"Transplantation"},{"key":"10.1136\/ard.2008.088120_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clim.2005.02.017","article-title":"In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation","volume":"115","author":"Earle","year":"2005","journal-title":"Clin Immunol"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2008.088120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T15:35:11Z","timestamp":1736091311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724216939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0003496724216939"],"URL":"https:\/\/doi.org\/10.1136\/ard.2008.088120","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2008.088120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 2009 Published by Elsevier Inc. Publishing Group and European League Against Rheumatism. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}