{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:21:09Z","timestamp":1775305269822,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1136\/ard.2008.094706","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T01:25:03Z","timestamp":1227144303000},"page":"1633-1637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women"],"prefix":"10.1016","volume":"68","author":[{"given":"S","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Solovieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Vehmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E-P","family":"Takala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Riihim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Leino-Arjas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2008.094706_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molmed.2005.02.005","article-title":"Recent advances in the genetic investigation of osteoarthritis","volume":"11","author":"Peach","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.1136\/ard.2008.094706_bib2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/ard.55.9.665","article-title":"Genetics of osteoarthritis","volume":"55","author":"Cicuttini","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2008.094706_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/ar380","article-title":"Collagen of articular cartilage","volume":"4","author":"Eyre","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1136\/ard.2008.094706_bib4","doi-asserted-by":"crossref","unstructured":"Eyre DR. Collagens and cartilage matrix homeostasis. Clin Orthop Relat Res 2004;(427 Suppl):S118\u201322.","DOI":"10.1097\/01.blo.0000144855.48640.b9"},{"key":"10.1136\/ard.2008.094706_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/1529-0131(199904)42:3<397::AID-ANR1>3.0.CO;2-X","article-title":"Genetics and osteoarthritis: exposing the iceberg","volume":"42","author":"Holderbaum","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2008.094706_bib6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/ard.2007.073874","article-title":"Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review","volume":"67","author":"Ryder","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2008.094706_bib7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(89)92507-5","article-title":"Predisposition to familial osteoarthrosis linked to type II collagen gene","volume":"1","author":"Palotie","year":"1989","journal-title":"Lancet"},{"key":"10.1136\/ard.2008.094706_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1469-1809.1996.tb00422.x","article-title":"Population haplotype analysis and evolutionary relations of the COL2A1 gene","volume":"60","author":"Meulenbelt","year":"1996","journal-title":"Ann Hum Genet"},{"key":"10.1136\/ard.2008.094706_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1469-1809.1999.6350393.x","article-title":"Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis","volume":"63","author":"Meulenbelt","year":"1999","journal-title":"Ann Hum Genet"},{"key":"10.1136\/ard.2008.094706_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00018-002-8402-1","article-title":"Molecular basis of osteoarthritis: biomechanical aspects","volume":"59","author":"Kerin","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1136\/ard.2008.094706_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/03008200490514121","article-title":"Cyclic loading can denature type II collagen in articular cartilage","volume":"45","author":"Clements","year":"2004","journal-title":"Connect Tissue Res"},{"key":"10.1136\/ard.2008.094706_bib12","doi-asserted-by":"crossref","unstructured":"Guilak F, Fermor B, Keefe FJ. The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res 2004;(423):17\u201326.","DOI":"10.1097\/01.blo.0000131233.83640.91"},{"key":"10.1136\/ard.2008.094706_bib13","series-title":"Osteoarthritis, inflammation and degradation: a continuum 1","first-page":"14","article-title":"Mechanical loading effects on articular cartilage matrix metabolism and osteoarthritis","author":"Smith","year":"2007"},{"key":"10.1136\/ard.2008.094706_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/154405910608500412","article-title":"Finger osteoarthritis and differences in dental work tasks","volume":"85","author":"Solovieva","year":"2006","journal-title":"J Dent Res"},{"key":"10.1136\/ard.2008.094706_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2008.094706_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/rheumatology\/keh534","article-title":"Hand use and patterns of joint involvement in osteoarthritis. A comparison of female dentists and teachers","volume":"44","author":"Solovieva","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1136\/ard.2008.094706_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1136\/ard.2008.094706_bib18","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"Am J Hum Genet"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724216344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2008.094706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T01:36:46Z","timestamp":1737250606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724216344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0003496724216344"],"URL":"https:\/\/doi.org\/10.1136\/ard.2008.094706","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2008.094706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier Inc. Publishing Group Ltd and European League Against Rheumatism. All rights reserved. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}