{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:17:51Z","timestamp":1790839071212,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ard.eular.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of the Rheumatic Diseases"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1136\/ard.2008.103663","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T01:13:43Z","timestamp":1236042823000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Circulating cytokines in active polymyalgia rheumatica"],"prefix":"10.1016","volume":"69","author":[{"given":"L","family":"Alvarez-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lopez-Hoyos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Jose","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Calvo-Alen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Aurrecoechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ruiz-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V M","family":"Mart\u00ednez-Taboada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ard.2008.103663_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra011913","article-title":"Polymyalgia rheumatica and giant cell arteritis.","volume":"347","author":"Salvarani","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1136\/ard.2008.103663_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/archinte.1997.00440240081012","article-title":"Polymyalgia rheumatica without significantly increased ESR: a more benign syndrome.","volume":"157","author":"Gonz\u00e1lez-Gay","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1136\/ard.2008.103663_bib3","doi-asserted-by":"crossref","first-page":"672","DOI":"10.7326\/0003-4819-97-5-672","article-title":"Polymyalgia rheumatica: a 10-year epidemiologic and clinical study.","volume":"97","author":"Chuang","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2008.103663_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cyto.2008.09.004","article-title":"Giant cell arteritis and polymyalgia rheumatica: role of cytokines in the pathogenesis and implications for treatment.","volume":"44","author":"Martinez-Taboada","year":"2008","journal-title":"Cytokine"},{"key":"10.1136\/ard.2008.103663_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/rheumatology\/39.6.624","article-title":"The adrenal steroid status in relation to inflammatory cytokines (interleukin-6 and tumor necrosis factor) in polymyalgia rheumatica.","volume":"39","author":"Straub","year":"2000","journal-title":"Rheumatology"},{"key":"10.1136\/ard.2008.103663_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2008.103663_bib7","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/art.1780360913","article-title":"Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis.","volume":"36","author":"Roche","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2008.103663_bib8","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/rheumatology\/36.9.976","article-title":"The sequential analysis of T lymphocyte subsets and interleukin-6 in polymyalgia rheumatica as predictors of disease remission and steroid withdrawal.","volume":"36","author":"Corrigal","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/rheumatology\/37.7.766","article-title":"Cytokines and adhesion molecules in patients with polymyalgia rheumatica.","volume":"37","author":"Uddhammar","year":"1998","journal-title":"Br J Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib10","first-page":"748","article-title":"Adrenal gland hypofunction in active polymyalgia rheumatica. Effect of glucocorticoid treatment on adrenal hormones and interleukin 6.","volume":"29","author":"Cutolo","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib11","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1136\/ard.2006.051979","article-title":"Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis.","volume":"63","author":"Cutolo","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2008.103663_bib12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7326\/0003-4819-121-7-199410010-00003","article-title":"Tissue cytokine patterns distinguish polymyalgia rheumatica and giant cell arteritis.","volume":"121","author":"Weyand","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1136\/ard.2008.103663_bib13","first-page":"1318","article-title":"Favorable role of interleukin 10 in patients with polymyalgia rheumatica.","volume":"26","author":"Straub","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/ard.55.6.403-b","article-title":"Interleukin-6 in clinical relapses of polymyalgia rheumatica and giant cell arteritis.","volume":"55","author":"Caplanne","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1136\/ard.2008.103663_bib15","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/art.1780390734","article-title":"Cytokines in polymyalgia rheumatica.","volume":"39","author":"Tellus","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2008.103663_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/rheumatology\/41.4.423","article-title":"In polymyalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers.","volume":"41","author":"Straub","year":"2002","journal-title":"Rheumatology"},{"key":"10.1136\/ard.2008.103663_bib17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/rheumatology\/37.7.797","article-title":"Circulating levels of IL-1beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatica and giant cell arteritis and rheumatoid arthritis.","volume":"37","author":"Pountain","year":"1998","journal-title":"Br J Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2249.2001.01621.x","article-title":"Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1\u03b2 after live yellow fever vaccination.","volume":"125","author":"Hacker","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2008.103663_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2249.1995.tb05549.x","article-title":"Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism.","volume":"99","author":"Danis","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2008.103663_bib20","first-page":"675","article-title":"Interleukin-1 cluster and tumor necrosis factor-\u03b1 gene polymorphisms in polymyalgia rheumatica.","volume":"18","author":"Boiardi","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"10.1136\/ard.2008.103663_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.humimm.2008.10.011","article-title":"Interleukin-1RN gene polymorphisms in elderly patients with rheumatoid inflammatory chronic conditions: association of IL-1RN*2\/2 genotype with polymyalgia rheumatica.","volume":"70","author":"Alvarez-Rodriguez","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1136\/ard.2008.103663_bib22","first-page":"1049","article-title":"Spontaneous cytokine production and its effect on induced production.","volume":"9","author":"Walker","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1136\/ard.2008.103663_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1128\/CDLI.8.6.1097-1103.2001","article-title":"Comparison of serum and cell-specific cytokines in humans.","volume":"8","author":"Jason","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1136\/ard.2008.103663_bib24","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.20050473","article-title":"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade.","volume":"201","author":"Pascual","year":"2005","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2008.103663_bib25","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.20021553","article-title":"Interferon and granulopoiesis signatures in systemic lupus erythematosus blood.","volume":"197","author":"Bennet","year":"2003","journal-title":"J Exp Med"},{"key":"10.1136\/ard.2008.103663_bib26","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","article-title":"Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist.","volume":"364","author":"Hoffman","year":"2004","journal-title":"Lancet"},{"key":"10.1136\/ard.2008.103663_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0022-1759(95)00209-X","article-title":"Detection of intracytoplasmatic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.","volume":"188","author":"Prussin","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1136\/ard.2008.103663_bib28","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1002\/art.22218","article-title":"Interleukin-10 promoter polymorphisms in giant-cell arteritis.","volume":"54","author":"Boiardi","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1136\/ard.2008.103663_bib29","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1046\/j.1365-2249.2000.01232.x","article-title":"Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes.","volume":"120","author":"Moss","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2008.103663_bib30","first-page":"996","article-title":"Increased frequencies of interleukin-2- and interferon-\u03b3-producing T cells in patients with active Beh\u00e7et's disease.","volume":"39","author":"Sugi-Ikai","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1136\/ard.2008.103663_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1046\/j.1365-2249.1996.d01-618.x","article-title":"Interferon-gamma treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats.","volume":"103","author":"Johansen","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1136\/ard.2008.103663_bib32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1699-0463.1997.tb05092.x","article-title":"Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB\/c mice compared to Th1 responding C3H\/HeN mice.","volume":"105","author":"Moser","year":"1997","journal-title":"APMIS"},{"key":"10.1136\/ard.2008.103663_bib33","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0140-6736(08)60453-5","article-title":"Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.","volume":"371","author":"Smolen","year":"2008","journal-title":"Lancet"}],"container-title":["Annals of the Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724196926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003496724196926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ard.2008.103663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T14:15:25Z","timestamp":1736086525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003496724196926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0003496724196926"],"URL":"https:\/\/doi.org\/10.1136\/ard.2008.103663","relation":{},"ISSN":["0003-4967"],"issn-type":[{"value":"0003-4967","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating cytokines in active polymyalgia rheumatica","name":"articletitle","label":"Article Title"},{"value":"Annals of the Rheumatic Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ard.2008.103663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Inc. Publishing Group Ltd and European League Against Rheumatism. All rights reserved. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}